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Clinical application of heart rate variability for child-onset neuromuscular diseases

Research Project

Project/Area Number 25860877
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionNagoya City University

Principal Investigator

HATTORI Ayako  名古屋市立大学, 大学院医学研究科, 助教 (80444975)

Research Collaborator HAYANO Junichiro  
MIZUNO Kumiko  
KURU Satoshi  
MOTOHASHI Yuko  
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords予後予測 / 心拍変動 / 神経筋疾患 / 心拍変動解析 / 小児
Outline of Final Research Achievements

The goal of this study is to find prognostic factors of neuromuscular disease, using heart rate variability. Here we investigated the relation between heart rate variability and mortality of Duchenne muscular dystrophy. We analyzed 77 24-hour holter ECG data of15 patients who died. Each parameters of heart rate variability was depressed nearing to death, statistically significant. But there were no significant correlations between arrhythmia and mortality. These results was similar to previous reports of myocardial infarction. Heart rate variability was suggested to predict the prognosis of patients with neuromuscular diseases.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2017 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (7 results)

  • [Journal Article] Semi-automatic volumetry of cortical tubers in tuberous sclerosis complex.2013

    • Author(s)
      Nakata Y, Sato N, Hattori A, Ito K, Kimura Y, Kamiya K, Shigemoto Y, Nakagawa E, Sasaki M, Ohtomo K
    • Journal Title

      Jpn J Radiol

      Volume: 31 Issue: 4 Pages: 253-61

    • DOI

      10.1007/s11604-012-0178-0

    • NAID

      50008697401

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phenotypic spectrum of COL4A1 mutations: porencephaly to schizencephaly2013

    • Author(s)
      Yoneda Y, Haginoya K,…..*Saitsu H
    • Journal Title

      Ann Neurol

      Volume: 73(1):48-57 Issue: 1 Pages: 48-57

    • DOI

      10.1002/ana.23736

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 遺伝子変異による先天異常 遺伝性巨脳症・片側巨脳症2013

    • Author(s)
      服部文子
    • Journal Title

      小児科臨床

      Volume: 66 Pages: 1339-1345

    • Related Report
      2013 Research-status Report
  • [Presentation] デュシェンヌ型筋ジストロフィーにおける心拍変動の特性(第二報)2017

    • Author(s)
      服部文子
    • Organizer
      第59回小児神経学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2017-06-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 慢性心不全の急性増悪に対し抗炎症療法を含めた総合的な治療により症状の軽快を得たDuchenne型筋ジストロフィーの12歳男児2015

    • Author(s)
      立川雅美子、堀いくみ、服部文子、安藤直樹、伊藤哲哉、齋藤伸治
    • Organizer
      第57回日本小児神経学会総会
    • Place of Presentation
      帝国ホテル大阪(大阪府大阪市)
    • Year and Date
      2015-05-28 – 2015-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] デュシェンヌ型筋ジストロフィーにおける心拍変動の特性(第一報)2014

    • Author(s)
      服部文子、堀いくみ、根岸豊、安藤直樹、伊藤哲哉、齋藤伸治
    • Organizer
      第56回日本小児神経学会総会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Research-status Report
  • [Presentation] デュシェンヌ型筋ジストロフィーにおける心拍変動解析の特性(第一報)2014

    • Author(s)
      服部文子 堀いくみ 根岸豊 安藤直樹 伊藤哲哉 齋藤伸治
    • Organizer
      第56回日本小児神経学会学術集会
    • Place of Presentation
      アクトシティ浜松(浜松)
    • Related Report
      2013 Research-status Report
  • [Presentation] AKT3遺伝子変異による巨脳症の一例2013

    • Author(s)
      服部文子 根岸豊 戸川貴夫 宮冬樹 安藤直樹 伊藤哲哉 角田達彦 金村米博 山崎麻美 小崎健次郎  齋藤伸治
    • Organizer
      第55回日本小児神経学会学術集会
    • Place of Presentation
      Iichiko総合文化センター(大分)
    • Related Report
      2013 Research-status Report
  • [Presentation] 脊髄性筋萎縮症1型における非侵襲的陽圧換気療法の経験

    • Author(s)
      服部文子 根岸豊 加藤沙耶香 遠藤剛 安藤直樹 伊藤哲哉 齋藤伸治
    • Organizer
      第5回東海神経筋疾患懇話会
    • Place of Presentation
      ウィンクあいち(名古屋)
    • Related Report
      2013 Research-status Report
  • [Presentation] 小児重症筋無力症に対する治療選択と課題

    • Author(s)
      山田千裕 服部文子 安藤直樹 小林悟 加藤沙耶香 根岸豊 遠藤剛 水野晴夫 伊藤哲哉 齋藤伸治
    • Organizer
      第39回日本小児神経学会東海地方会
    • Place of Presentation
      名古屋大学医学部医系研究棟1号館(名古屋)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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