The role of fibrocytes in the pathophysiology of renal fibrosis in polycystic kidney disease
Project/Area Number |
25860879
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pediatrics
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Research Institution | Wakayama Medical University |
Principal Investigator |
Hama Taketsugu 和歌山県立医科大学, 医学部, 博士研究員 (00508020)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 多発性嚢胞腎 / fibrocyte / 線維化 / CPKマウス / ARPKD / 繊維化 |
Outline of Final Research Achievements |
The pathophysiology of cystic epithelia in polycystic kidney disease (PKD) is characterized by altered proliferative activity, a secretory rather than absorptive function, and an abnormal matrix microenvironment. However, the aspect of extracellular matrix abnormality, especially fibrosis, has not been fully investigated in PKD. Recently, circulating fibrocytes expressing both leukocyte and mesenchymal antigens have been clarified to have a key role of progressing fibrosis in any organ. Therefore, we investigate fibrocytes contribution in cpk mouse.As a result, collagen type I gene level expressed significantly higher in cpk mice than control. CD45 and collagen dual-positive cells were detected predominantly in cpk mice. These findings suggested that fibrocytes were recruited in cpk and participated in the progression of fibrosis. Therefore, they may be new targets for a disease-specific intervention.
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Report
(5 results)
Research Products
(10 results)
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[Presentation] Smad3 Gene Deletion Ameliorates Cyst Formation and Interstitial Fibrosis in cpk mouce, a Model of ARPKD2014
Author(s)
Taketsugu Hama, Koichi Nakanishi, Hironobu Mukaiyama, Hiroko Togawa, Masashi Sato, Yuko Shima, Masayasu Miyajima, Kandai Nozu, Shizuko Nagao, Hisahide Takahashi, Kazumoto Iijima and Norishige Yoshikawa
Organizer
American Society of Nephrology (ASN) Kidney Week 2014
Place of Presentation
アメリカ合衆国 フィラデルフィア
Year and Date
2014-11-11 – 2014-11-16
Related Report
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[Presentation] Possible contribution of fibrocytes to renal fibrosis in cpk mouse, a model of ARPKD2013
Author(s)
Taketsugu Hama, Koichi Nakanishi, Hironobu Mukaiyama, Masashi Sato, Hiroko Togawa, Yuko Shima, Masayasu Miyajima, Hisahide Takahashi, Shizuko Nagao, Kazumoto Iijima and Norishige Yoshikawa
Organizer
International Pediatric Nephrology Association (IPNA) 2013
Place of Presentation
中国 上海
Related Report
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[Presentation] Smad3 phosphorylated at both linker and COOH-terminal regions in cyst-lining epithelia in cpk mouse, a model of ARPKD2013
Author(s)
Taketsugu Hama, Koichi Nakanishi, Hironobu Mukaiyama, Hiroko Togawa, Masashi Sato, Yuko Shima, Masayasu Miyajima, Kandai Nozu, Shizuko Nagao, Hisahide Takahashi, Kazumoto Iijima and Norishige Yoshikawa
Organizer
American Society of Nephrology (ASN) Kidney Week 2013
Place of Presentation
アメリカ合衆国 アトランタ
Related Report