ST2 gene expression and transcriptional mechanisms in children with allergic disease
| Project/Area Number |
25860883
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Juntendo University |
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Principal Investigator |
BABA Yosuke 順天堂大学, 医学部, 助教 (40647971)
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| Research Collaborator |
SHIMIZU Toshiaki 順天堂大学, 医学部, 教授 (30260889)
OHTSUKA Yoshikazu 順天堂大学, 医学部, 客員准教授 (90338335)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 小児アレルギー / IL-33 / ST2 / Th2細胞 / 粘膜免疫 / ST2遺伝子 / IL-33受容体 / インフラマソーム / 転写調節因子 / 遺伝子発現 / IL33受容体 / Th2免疫応答 |
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| Outline of Final Research Achievements |
We conducted a functional analysis of IL-33R/ST2 in the infantile allergic disease. We could confirm ST2 elevation in allergic inflammation in an each disease and a cellular experiment. And immunocompetent cells proved that onset of ST2 changed quantitatively in a process indicating the acquisition of resistance in children with allergic disease. The IgA antibody is massively produced in the intestinal Peyer’s patches, and the secretory IgA (sIgA) plays an important role on mucosal immune responses. It is considered that sIgA regulates the cause of allergic reactions, but the mechanism by which sIgA recognizes some antigens has not been clarified in food allergy. We strengthened an immune response of the Th1 cell line, and zinc acted on skin and mucosal maintenance.
We concluded that ST2 is an important factor in allergic diseases and speculated that it is because the relationships ST2 and IL-33 played an important role in children with allergy.
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Report
(5 results)
Research Products
(22 results)
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[Journal Article] Serum ST2, but not IL-33, is elevated in children with food allergy due to low dose baked milk.2017
Author(s)
Baba Y, Yoneyama T, Yamada H, Yamazaki S, Hong A, Inage E, Mori M, Ohtsuka Y, Kantake M, Shimizu T.
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Journal Title
J Allergy Clin Immunol.
Volume: 139
Issue: 2
Pages: AB264-AB264
DOI
Related Report
Peer Reviewed
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[Journal Article] Critical Roles for PU.1, GATA1, and GATA2 in the Expression of Human FcεRI on Mast Cells: PU.1 and GATA1 Transactivate FCER1A, and GATA2 Transactivates FCER1A and MS4A22014
Author(s)
Inage E, Kasakura K, Yashiro T, Suzuki R, Baba Y, Nakano N, Hara M, Tanabe A, Oboki K, Matsumoto K, Saito H, Niyonsaba F, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, and Nishiyama C
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Journal Title
Journal of Immunology
Volume: 192
Issue: 8
Pages: 3936-46
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Serum ST2, but Not IL-33, Is Elevated in Children with Food Allergy Due to Low Dose Baked Milk2017
Author(s)
Baba Y, Yoneyama T, Yamada H, Yamazaki S, Hong A, Inage E, Mori M, Ohtsuka Y, Kantake M, Shimizu T.
Organizer
The 73rd Annual Meeting of American Academy of Allergy Asthma and Immunology
Place of Presentation
Atlanta, GA, United States
Year and Date
2017-03-03
Related Report
Int'l Joint Research
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[Presentation] A Retrospective Study of the Serum IgA levels in Food Allergy Patients.2014
Author(s)
Yosuke Baba, Yoshikazu Ohtsuka, Tomoaki Yokokura, Reina Yokota, Susumu Yamazaki, Asuka Ishida, Eisuke Inage, Mari Mori, Ryuyo Suzuki, Toshiaki Shimizu.
Organizer
The Pediatric Academic Societies Annual Meeting
Place of Presentation
Vancouver, Canada
Year and Date
2014-05-03 – 2014-05-06
Related Report
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