The analysis between HHV-6B and medial temporal lobe epilepsy

• Project/Area Number: 25860888
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Fujita Health University
• Principal Investigator: KAWAMURA Yoshiki 藤田保健衛生大学, 医学部, 助教 (30581475)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ヒトヘルペスウイルス6 / 内側側頭葉硬化症 / 宿主遺伝子発現 / 内側側頭葉てんかん

Outline of Final Research Achievements

We analyzed brain samples of intractable epilepsy patients who took neurosurgery in order to elucidate association between mesial temporal lobe sclerosis (MTS) which is intractable epilepsy and human herpesvirus 6 (HHV-6). HHV-6 was the most detected virus in 8 human herpesviruses. And HHV-6 DNA loads were significantly higher in the MTS than non-MTS patients.
Some host gene expressions were significantly higher levels in MTS patients with HHV-6 than those without HHV-6. These results suggested that the association between MTS and HHV-6.

Research Products

• [Journal Article] Pathogenic Role of Human Herpesvirus 6B Infection in Mesial Temporal Lobe Epilepsy. (2015)
  • Author(s): Kawamura Y, Nakayama A, Kato T, Miura H, Ishihara N, Ihira M, Takahashi Y, Matsuda K, Yoshikawa T.
  • Journal Title: Journal of Infectious disease Volume: 印刷中 Issue: 7 Pages: 1014-21
  • DOI: 10.1093/infdis/jiv160
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Pathogenic role of human herpesvirus 6B (HHV-6B) in mesial temporal sclerosis (2014)
  • Author(s): Yoshiki Kawamura, Hiroki Miura, Naoko Ishihara, Masaru Ihira, Yukitoshi Takahashi, Kazumi Matsuda, Tetsushi Yoshikawa
  • Organizer: IDWeek 2014
  • Place of Presentation: 米国、ペンシルバニア州、フィラデルフィア、ペンシルバニアコンベンションセンター
  • Year and Date: 2014-10-08 – 2014-10-12
• [Presentation] Pathogenic role of human herpesvirus 6B in mesial temporal sclerosis (2014)
  • Author(s): Yoshiki Kawamura, Hiroki Miura, Naoko Ishihara, Masaru Ihira, Yukitoshi Takahashi, Kazumi Matsuda, Tetsushi Yoshikawa
  • Organizer: The 48th Congress of the Japan Epilepsy Society
  • Place of Presentation: 東京都、新宿区、京王プラザホテル
  • Year and Date: 2014-10-02 – 2014-10-04
• [Presentation] 内側側頭葉硬化症発症における ヒトヘルペスウイルス6Bの役割 (2014)
  • Author(s): 河村吉紀、三浦浩樹、井平 勝, 高橋幸利、松田一己、吉川哲史
  • Organizer: 第19回日本神経感染症学会総会学術集会
  • Place of Presentation: 石川県、金沢市、金沢歌劇座
  • Year and Date: 2014-09-04 – 2014-09-06
• [Presentation] Pathogenic role of human herpesvirus 6B in mesial temporal sclerosis (2014)
  • Author(s): Yoshiki Kawamura, Hiroki Miura, Masaru Ihira, Yukitoshi Takahashi, Kazumi Matsuda, Tetsushi Yoshikawa
  • Organizer: 39th Annual International Herpesvirus Workshop 2014
  • Place of Presentation: 兵庫県、神戸市、神戸コンベンションセンター
  • Year and Date: 2014-07-19 – 2014-07-23
• [Presentation] 内側側頭葉てんかん発症における ヒトヘルペスウイルス6Bの役割 (2014)
  • Author(s): 河村吉紀、三浦浩樹、井平 勝、吉川哲史
  • Organizer: 第55回日本臨床ウイルス学会
  • Place of Presentation: 北海道、札幌市、ロイトン札幌
  • Year and Date: 2014-06-14 – 2014-06-15
• [Presentation] 内側側頭葉硬化症発症における ヒトヘルペスウイルス6Bの役割 (2014)
  • Author(s): 河村吉紀、三浦浩樹、松岡恵里菜、井平 勝、 高橋幸利、松田一己、吉川哲史
  • Organizer: 第117回日本小児科学会学術集会
  • Place of Presentation: 愛知県、名古屋市、名古屋国際会議場
  • Year and Date: 2014-04-11 – 2014-04-13
• [Presentation] 内側側頭葉硬化症発症におけるヒトペルペスウイルス6Bの役割 (2013)
  • Author(s): 河村吉紀
  • Organizer: 第45回日本小児感染症学会総会・学術集会
  • Place of Presentation: 北海道札幌市
• [Presentation] 内側側頭葉硬化症発症におけるヒトペルペスウイルス6Bの役割 (2013)
  • Author(s): 河村吉紀
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 兵庫県神戸市
• [Presentation] 内側側頭葉硬化症発症におけるヒトペルペスウイルス6Bの役割 (2013)
  • Author(s): 河村吉紀
  • Organizer: 第18回日本神経感染症学会総会学術集会
  • Place of Presentation: 宮崎県宮崎市