The analysis between HHV-6B and medial temporal lobe epilepsy
| Project/Area Number |
25860888
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ヒトヘルペスウイルス6 / 内側側頭葉硬化症 / 宿主遺伝子発現 / 内側側頭葉てんかん |
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| Outline of Final Research Achievements |
We analyzed brain samples of intractable epilepsy patients who took neurosurgery in order to elucidate association between mesial temporal lobe sclerosis (MTS) which is intractable epilepsy and human herpesvirus 6 (HHV-6). HHV-6 was the most detected virus in 8 human herpesviruses. And HHV-6 DNA loads were significantly higher in the MTS than non-MTS patients.
Some host gene expressions were significantly higher levels in MTS patients with HHV-6 than those without HHV-6. These results suggested that the association between MTS and HHV-6.
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Report
(3 results)
Research Products
(10 results)
