| Project/Area Number |
25860893
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan (2013, 2015)
Saitama Medical University (2014) |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 乳児肥満 / PCSK9 / BDNF / NAFLD / BMI / 小児肥満 / 周産期 / DoHaD |
|---|
| Outline of Final Research Achievements |
We have revealed that the changes of body mass index (BMI) of very low birth weight infant during first three years might be affected by their birth size and weight gain in the Neonatal intensive care unit. Additionally, there were close relationships between infantile weight gain associated with childhood obesity and perinatal factors; e.g. maternal BMI or weight gain during pregnancy by questionnaire survey. We also reported the levels of Proprotein convertase subtilisin/kexin type 9 in neonate period and those of Tissue inhibitor of matrix metalloproteinase 1, Brain-derived neurotrophic factor and chemokines in childhood obesity. Circulating BDNF levels, which were decreased in the morbidly obese children, were associated with their birth weight. Therfore, our results suggested that BDNF might play important roles in the development and pathophysiology of childhood obesity.
|
