| Project/Area Number |
25860902
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
Funamoto Kiyoe 東北大学, 医学(系)研究科(研究院), 技術補佐員 (30570030)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ビタミンA（レチノイン酸） / 小耳症 / 胎児心電図 / レチノイン酸 / 先天性奇形 / ビタミンＡ |
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| Outline of Final Research Achievements |
Teratogenicity of Vitamin A has been studied for many years, and also reported the spectrum such as microtia and heart malformations. In this study, experiments were carried out for the impact of vitamin A overdose of early pregnancy, especially observed the ear developing.
Mouse pinna usually develops after the birth and the ear canal opens around day 10. However, new born mouse which observed Pinna abnormalities died all within 48 hours after birth. Therefore, we measured the fetal cardiac potential using mouse fetal electrocardiogram and detected the unusual waveforms. Moreover, gene expression related to heart function was detected.As a result, the presence of genes associated with cardiac and auricle that is the same origin embryogenesis was suggested.
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