Combined action of environmental and genetical factors on mail genital abnormalities
| Project/Area Number |
25860905
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
Ohishi Akira 浜松医科大学, 医学部, 助教 (80402337)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJISAWA Yasuko 浜松医科大学, 医学部, 講師 (40402284)
OGATA Tsutomu 浜松医科大学, 医学部, 教授 (40169173)
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| Research Collaborator |
FUKAMI Maki 国立成育医療研究センター
SONE Hideko 独立行政法人国立環境研究所
YOSHINAGA Jun 東京大学, 新領域創成科学研究科
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 性分化 / 環境ホルモン / ステロイド / エストロゲン / 感受性遺伝子 / 環境化学物質 / 内分泌撹乱ホルモン / 精巣異形成症候群 / 女性化 / 性分化異常 / DOHaD |
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| Outline of Final Research Achievements |
We gained the two new insights by this grant. First, we performed steroid profiling of umbilical cord blood from normal now borns by LC-MS/MS-based method. Given that there are still some unclear points of androgen generation during fetal period, those results are quite important for research on gonadal sex differentiation. Second, we analyzed the frequency of a 2244 base pair deletion within intron 6 of the ESR1 gene that is the significant gene modification involving increased sensitivity to estrogenic endocrine disruptors. We identified that this deletion has recessive effect on male genital abnormalities. Furthermore, the number of subjects involving with this deletion was higher in normal adult male group than in normal boy group, indicating that the sensitive subjects to estrogenic endocrine disruptors tended to to be born with normal genitals during past decades when the level of endocrine disruptors was low.
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Report
(4 results)
Research Products
(4 results)
