Developing a novel therapy with anti-A receptor antibody for perinatal brain injuries

• Project/Area Number: 25860907
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Nagoya University
• Principal Investigator: Saito Akiko 名古屋大学, 医学部附属病院, 病院助教 (50615276)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 周産期低酸素性虚血性脳症 / 周産期低酸素性虚血製脳症 / サイトカイン / 周産期脳障害 / 低酸素性虚血性脳症

Outline of Final Research Achievements

It is urgent to develop novel therapies for infants with perinatal hypoxic-ischemic encephalopathy (HIE). In the present project, we evaluated whether anti-A receptor antibody can exert treatment effect against perinatal HIE or not with perinatal HIE mice. We found that intraperitoneal injection of anti-A receptor antibody suppressed apoptosis, leading to smaller infarct volume. Anti-A receptor antibody injected intraperitoneally could migrated into injured brain, and increased serum cytokine A level significantly.

Research Products

• [Journal Article] Multicenter observational study comparing sedation/analgesia protocols for laser photocoagulation treatment of retinopathy of prematurity. (2015)
  • Author(s): Sato Y, Oshiro M, Takemoto K, Hosono H, Saito A, Kondo T, Aizu K, Matsusawa M, Futamura Y, Asami T, Terasaki H, Hayakawa M.
  • Journal Title: J Perinatol. Volume: 35 Issue: 11 Pages: 965-9
  • DOI: 10.1038/jp.2015.112
  • Peer Reviewed / Open Access
• [Journal Article] 母子感染からみた新生児細菌感染症 (2014)
  • Author(s): 齊藤明子、早川昌弘
  • Journal Title: 周産期医学増刊：周産期感染症2014 / 東京医学社 Volume: 44 Pages: 294-296
• [Presentation] 右気管支狭窄に伴う過膨張肺に対し右肺全摘後、気管気管支軟化症のため外固定術を要した一例 (2014)
  • Author(s): 齊藤明子、伊藤美春、孫田みゆき、村松友佳子、佐藤義朗、早川昌弘, 内田広夫
  • Organizer: 東海新生児研究会
  • Place of Presentation: 名古屋市立大学（名古屋市）
  • Year and Date: 2014-11-29
• [Presentation] 当院におけるNICUアウトブレイクとその対応 (2014)
  • Author(s): 齊藤明子
  • Organizer: 小児科学会東海地方会
  • Place of Presentation: 藤田保健衛生大学（豊明市）
  • Year and Date: 2014-10-05
  • Invited
• [Presentation] HIEモデルマウスにおける抗IL-6レセプター抗体の効果 (2014)
  • Author(s): 齊藤明子、佐藤義朗、鈴木俊彦、杉山裕一朗、伊藤美春、孫田みゆき、近藤大貴、 藤巻英彦、中村裕子、佐藤義朗、早川昌弘
  • Organizer: 第50回周産期新生児学会
  • Place of Presentation: シェラトン・グランデ・トーキョーベイ・ホテル（浦安市）
  • Year and Date: 2014-07-15
• [Presentation] Opitz Kaveggia症候群を疑う一例 (2014)
  • Author(s): 齊藤明子
  • Organizer: 第23回 Dysmorphologyの夕べ
  • Place of Presentation: 名古屋市立大学（名古屋市）
  • Year and Date: 2014-04-10
• [Presentation] 当院ＮＩＣＵにおけるＭＲＳＡアウトブレイクと、その対応 (2013)
  • Author(s): 齊藤明子
  • Organizer: 第58回日本未熟児新生児学会
  • Place of Presentation: 石川県立音楽堂（金沢市）
  • Invited
• [Patent(Industrial Property Rights)] 新生児低酸素性虚血性脳症の予防又は治療剤及びその利用 (2014)
  • Inventor(s): 佐藤義朗 齊藤明子
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-02-07