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Developing a novel therapy with anti-A receptor antibody for perinatal brain injuries

Research Project

Project/Area Number 25860907
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionNagoya University

Principal Investigator

Saito Akiko  名古屋大学, 医学部附属病院, 病院助教 (50615276)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords周産期低酸素性虚血性脳症 / 周産期低酸素性虚血製脳症 / サイトカイン / 周産期脳障害 / 低酸素性虚血性脳症
Outline of Final Research Achievements

It is urgent to develop novel therapies for infants with perinatal hypoxic-ischemic encephalopathy (HIE). In the present project, we evaluated whether anti-A receptor antibody can exert treatment effect against perinatal HIE or not with perinatal HIE mice. We found that intraperitoneal injection of anti-A receptor antibody suppressed apoptosis, leading to smaller infarct volume. Anti-A receptor antibody injected intraperitoneally could migrated into injured brain, and increased serum cytokine A level significantly.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (5 results) (of which Invited: 2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Multicenter observational study comparing sedation/analgesia protocols for laser photocoagulation treatment of retinopathy of prematurity.2015

    • Author(s)
      Sato Y, Oshiro M, Takemoto K, Hosono H, Saito A, Kondo T, Aizu K, Matsusawa M, Futamura Y, Asami T, Terasaki H, Hayakawa M.
    • Journal Title

      J Perinatol.

      Volume: 35 Issue: 11 Pages: 965-9

    • DOI

      10.1038/jp.2015.112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 母子感染からみた新生児細菌感染症2014

    • Author(s)
      齊藤明子、早川昌弘
    • Journal Title

      周産期医学増刊:周産期感染症2014 / 東京医学社

      Volume: 44 Pages: 294-296

    • Related Report
      2014 Research-status Report
  • [Presentation] 右気管支狭窄に伴う過膨張肺に対し右肺全摘後、気管気管支軟化症のため外固定術を要した一例2014

    • Author(s)
      齊藤明子、伊藤美春、孫田みゆき、村松友佳子、佐藤義朗、早川昌弘, 内田広夫
    • Organizer
      東海新生児研究会
    • Place of Presentation
      名古屋市立大学(名古屋市)
    • Year and Date
      2014-11-29
    • Related Report
      2014 Research-status Report
  • [Presentation] 当院におけるNICUアウトブレイクとその対応2014

    • Author(s)
      齊藤明子
    • Organizer
      小児科学会東海地方会
    • Place of Presentation
      藤田保健衛生大学(豊明市)
    • Year and Date
      2014-10-05
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] HIEモデルマウスにおける抗IL-6レセプター抗体の効果2014

    • Author(s)
      齊藤明子、佐藤義朗、鈴木俊彦、杉山裕一朗、伊藤美春、孫田みゆき、近藤大貴、 藤巻英彦、中村裕子、佐藤義朗、早川昌弘
    • Organizer
      第50回周産期新生児学会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(浦安市)
    • Year and Date
      2014-07-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Opitz Kaveggia症候群を疑う一例2014

    • Author(s)
      齊藤明子
    • Organizer
      第23回 Dysmorphologyの夕べ
    • Place of Presentation
      名古屋市立大学(名古屋市)
    • Year and Date
      2014-04-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 当院NICUにおけるMRSAアウトブレイクと、その対応2013

    • Author(s)
      齊藤明子
    • Organizer
      第58回日本未熟児新生児学会
    • Place of Presentation
      石川県立音楽堂(金沢市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] 新生児低酸素性虚血性脳症の予防又は治療剤及びその利用2014

    • Inventor(s)
      佐藤義朗 齊藤明子
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-07
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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