Developing a novel therapy with anti-A receptor antibody for perinatal brain injuries
| Project/Area Number |
25860907
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
Saito Akiko 名古屋大学, 医学部附属病院, 病院助教 (50615276)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 周産期低酸素性虚血性脳症 / 周産期低酸素性虚血製脳症 / サイトカイン / 周産期脳障害 / 低酸素性虚血性脳症 |
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| Outline of Final Research Achievements |
It is urgent to develop novel therapies for infants with perinatal hypoxic-ischemic encephalopathy (HIE). In the present project, we evaluated whether anti-A receptor antibody can exert treatment effect against perinatal HIE or not with perinatal HIE mice. We found that intraperitoneal injection of anti-A receptor antibody suppressed apoptosis, leading to smaller infarct volume. Anti-A receptor antibody injected intraperitoneally could migrated into injured brain, and increased serum cytokine A level significantly.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Multicenter observational study comparing sedation/analgesia protocols for laser photocoagulation treatment of retinopathy of prematurity.2015
Author(s)
Sato Y, Oshiro M, Takemoto K, Hosono H, Saito A, Kondo T, Aizu K, Matsusawa M, Futamura Y, Asami T, Terasaki H, Hayakawa M.
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Journal Title
J Perinatol.
Volume: 35
Issue: 11
Pages: 965-9
DOI
Related Report
Peer Reviewed / Open Access
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