• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Does the disruption of circadian rhythms during development affect metabolism in adulthood?

Research Project

Project/Area Number 25860910
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Embryonic/Neonatal medicine
Research InstitutionThe University of Tokushima

Principal Investigator

SAWADA Naoki  徳島大学, ヘルスバイオサイエンス研究部, 助教 (50452644)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords概日リズム / レプチン / 母仔分離 / ラット / DOHaD / 肥満
Outline of Final Research Achievements

To reveal the effect of the disruption of the circadian rhythm (CR) during development on the metabolism in adulthood, rat pups were deranged of the CR by periodic maternal separation (MS) during the suckling period. Under light and dark cycle, deranged group showed a significant increase in body weight and food intake compared with the control. Serum leptin level at 8 weeks old (w), retroperitoneal fat depot on 9 w, amount of a high fat diet intake of 14 w, and the area under the curve of the oral glucose tolerance test on 21 w of CR-deranged group were significantly higher than those of the control. Under the constant light, however, there was no difference in body weight between two groups. These results suggest that the effect of CR-derangement by MS can remain after growth as hormonal, behavioral and metabolic changes by the relations with the light and dark cycle, although it does not give a profound effect on pups alone without resetting of CR by light and dark cycle.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2014 2013

All Journal Article (1 results) (of which Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] Effects of periodic maternal separation on fat mass of rat offspring in adulthood vary with the separation timing, during either light or dark phase2014

    • Author(s)
      Sawada N, Sakata-Haga H, Fukui Y
    • Journal Title

      Congenital anomalies (Abstract)

      Volume: 54(4) Issue: 4

    • DOI

      10.1111/cga.12089

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Presentation] 母仔分離のタイミングが成熟後の脂肪蓄積に与える影響2014

    • Author(s)
      澤田 直樹、坂田ひろみ、福井 義浩
    • Organizer
      第54回日本先天異常学会学術集会
    • Place of Presentation
      麻布大学(神奈川県相模原市)
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 母仔分離法を用いた発達期における概日リズム撹乱モデルの解析2013

    • Author(s)
      澤田 直樹、坂田 ひろみ、中川 俊、金井 友宏、福井 義浩
    • Organizer
      先天異常学会第53回学術集会
    • Place of Presentation
      大阪千里ライフサイエンスセンター(大阪府豊中市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 幼若期の生活リズムの乱れが成長に与える影響2013

    • Author(s)
      澤田 直樹、坂田 ひろみ、福井 義浩
    • Organizer
      日本解剖学会第68回中国・四国支部学術集会
    • Place of Presentation
      鳥取大学医学部(鳥取県米子市)
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi