Monitoring cerebral hemodynamics and neural activiity using TRS and EEG can predict the severity of brain injury in asphyxiated newborn piglet

• Project/Area Number: 25860911
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kagawa University
• Principal Investigator: Nakamura Shinji 香川大学, 医学部附属病院, 助教 (30437686)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 新生仔豚 / 低酸素虚血 / 脳波抑制 / 脳血液量 / 低酸素性虚血性脳症 / GFAP / 白質障害 / 時間分解分光装置 / 脳波 / 低体温療法 / 低酸素虚血性脳症

Outline of Final Research Achievements

Monitoring cerebral neural suppression and hemodynamics using aEEG and Time resolved spectroscopy in asphyxiated piglet and HIE neonates.
The aim of this study is to examine the relationship between changes in cerebral blood volume (CBV) and and the low amplitude-integrated electroencephalography (aEEG) duration (LAEEG) after a HI insult. The following results had been reported. At first, there was a positive linear correlation between changes in cerebral blood volume and low-amplitude aEEG duration within 6h after HI insult. Secondly, asphyxiated piglets showed that their histopathological cerebral damages correlated with increase in CBV after HI insult. Furthermore, in clinical study, neonates with severe brain damage also showed increase in CBV within 12 h after birth compared with healthy neonates. Since, an early increase in CBV and longer LAEEG indicate severe brain injury.

Research Products

• [Journal Article] Hypoxic-Ischemic Encephalopathy-Associated Liver Fatty Degeneration and the Effects of Therapeutic Hypothermia in Newborn Piglets. (2017)
  • Author(s): Kubo H, Shimono R, Nakamura S, Koyano K, Jinnai W, Yamato S, Yasuda S, Nakamura M, Tanaka A, Fujii T, Kanenishi K, Chiba Y, Miki T, Kusaka T, Ueno M.
  • Journal Title: Neonatology Volume: 111 Issue: 3 Pages: 203-210
  • DOI: 10.1159/000450721
  • Peer Reviewed / Open Access
• [Journal Article] Cerebral haemodynamic response to somatosensory stimulation in near-term fetal sheep (2017)
  • Author(s): 1.Nakamura S, Walker D.W., Wong F.Y.
  • Journal Title: J Physiol Volume: ５９５ Issue: 4 Pages: 1289-1303
  • DOI: 10.1113/jp273163
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cerebral blood volume measurement using near-infrared time-resolved spectroscopy and histopathological evaluation after hypoxic-ischemic insult in newborn piglets. (2015)
  • Author(s): Nakamura M, Jinnai W, Hamano S, Nakamura S, Koyano K, Chiba Y, Kanenishi K, Yasuda S, Ueno M, Miki T, Hata T, Kusaka T.
  • Journal Title: International Journal of Developmental Neuroscience Volume: 42 Issue: 1 Pages: 1-9
  • DOI: 10.1016/j.ijdevneu.2015.02.009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Relationship between early changes in cerebral blood volume and electrocortical activity after hypoxic-ischemic insult in newborn piglets. (2014)
  • Author(s): Nakamura S, Kusaka T, Koyano K, Miki T, Ueno M, Jinnai W, Yasuda S, Nakamura M, Okada H, Isobe K, Itoh S.
  • Journal Title: Brain Dev Volume: 36 Issue: 7 Pages: 563-571
  • DOI: 10.1016/j.braindev.2013.08.005
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of cerebral circulation and oxygen metabolism in infants using near-infrared light. (2014)
  • Author(s): Kusaka T, Isobe K, Yasuda S, Koyano K, Nakamura S, Nakamura M, Ueno M, Miki T, Itoh S.
  • Journal Title: Brain Dev. Volume: 36 Issue: 4 Pages: 277-283
  • DOI: 10.1016/j.braindev.2013.05.011
  • Peer Reviewed / Open Access
• [Journal Article] Simultaneous measurement of cerebral hemoglobin oxygen saturation and blood volume in asphyxiated neonates by near-infrared time-resolved spectroscopy
  • Author(s): Nakamura S, Koyano K, Jinnai W, Hamano S, Yasuda S, Konishi Y, Kuboi T, Kanenishi K, Nishida T, Kusaka T
  • Journal Title: Brain & Dev Volume: 37 Issue: 10 Pages: 925-932
  • DOI: 10.1016/j.braindev.2015.04.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 新生仔豚を用いた新生児低酸素性虚血性脳症モデルにおける肝障害の病理組織学的検討. (2015)
  • Author(s): 久保裕之
  • Organizer: .第５１回日本周産期・新生児医学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-07-10
• [Presentation] Relationship between cerebral hemodynamics after hypoxic_ischemic insult and cerebral metabolism in newborn piglet (2015)
  • Author(s): Saneyuki Yasuda
  • Organizer: The 11th Congress of Asian Society for Pediatric Research
  • Place of Presentation: 大阪
  • Year and Date: 2015-04-15
  • Int'l Joint Research
• [Presentation] Relationship between Early Changes in Cerebral Blood Volume and Electrocortical Activity after Hypoxic - Ischemic Insult in Newborn Piglets. (2013)
  • Author(s): Nakamura Shinji
  • Organizer: The 9th Annual Conference for Asian Society for Paediatric Research
  • Place of Presentation: Sarawak, Malaysia
• [Presentation] Relationship between Early Changes in Cerebral Blood Volume and Electrocortical Activity after Hypoxic - Ischemic Insult in Newborn Piglets. (2013)
  • Author(s): Nakamura Shinji
  • Organizer: International congress of pediatrics 2013
  • Place of Presentation: Melbourne, Australia