Development of diagnostic test for cutaneous adverse drug reaction.

Research Project

Project/Area Number	25860924
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Dermatology
Research Institution	Hokkaido University
Principal Investigator	MURATA Jyunko 北海道大学, 医学(系)研究科(研究院), 客員研究員 (10598387)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	重症薬疹 / 診断マーカー / 診断キット
Outline of Final Research Achievements	Severe cutaneous adverse drug reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis) are life-threating diseases. In this project, we investigated to identify diagnostic and prognostic markers using patients’ PBMCs. Patients’ PBMCs were stimulated with causative drugs and mRNA and proteins were collected. These mRNA and proteins profiles were compared to those of non-severe cutaneous adverse drug reactions (maculopapular tyoe). We identified sFasL and granulysin are the markers.