| Project/Area Number |
25860955
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | 全身性強皮症 / サイトカイン / リンパ球 / 免疫抑制剤 / mRNA |
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| Outline of Final Research Achievements |
At first, we examined the levels of proteins which extracted from skin sample of patients with systemic sclerosis (SSc) by the ELISA Array analysis. We focused on CD70 and IL-16 that were highly expressed before treatment and down-regulated after immunosuppressive therapy.Next, we performed immunohistochemistry of involved skin specimen. CD70-CD27 and IL-16 were overexpressed in the skin of SSc patients. Furthermore, soluble CD27 and IL-16 were also highly expressed in the sera of SSc patients by the sandwich ELISA.
In conclusion, CD70-CD27 signaling and IL-16 are upregulated in SSc patients, and the activated T lymphocytes might play an important role in the pathogenesis of SSc.
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