| Project/Area Number |
25860961
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | カポジ肉腫 / HHV8 / ヒトヘルペスウイルス8型 / 沖縄 / 宮古 / ウイルス発癌 / 宮古島 / カポシ肉腫 / ヒトヘルペス8型ウイルス / 血管肉腫 |
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| Outline of Final Research Achievements |
We found the high seropositivity of human herpesvirus 8 (HHV8) in the population of Miyako Islands, where people have a greater chance of developing non-AIDS associated Kaposi’s sarcoma. The seroprevalence of HHV8 was 15.37% in Miyako Island,that is approximately 11 times higher than those of Okinawa Islands and Japan. The prevalence rate increased with age, and there was little difference between men and women (16.55% and 14.10%).
Meanwhile, estimated incidence of non-AIDS associated Kaposi’s sarcoma was about 35 times higher in Miyako Islands than that in Okinawa Islands. These date support the hypothesis that the additional factors, such as the variants of HHV8 virus or the presence of host genetic factors, other than HHV8 infection rate, may be involved in Kaposi’s sarcoma development.
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