The role of nestin-expressing hair follicle stem cells in the recovery of peripheral nerve injury and establishment of new treatment
| Project/Area Number |
25860966
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
Mii Sumiyuki 北里大学, 医学部, 准教授 (80337948)
|
|---|
| Research Collaborator |
AMOH Yasuyuki 北里大学, 医学部, 教授
KAWAHARA Katsumasa 北里大学, 医学部, 教授
Hoffman Robert M. University of California San Diego, Professor, AntiCancer CEO
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | 末梢神経障害 / 幹細胞 / 末梢神経再生 / 毛包幹細胞 / 神経障害 / 国際情報交換 / アメリカ / 神経再生 |
|---|
| Outline of Final Research Achievements |
Neural stem cell marker nestin-expressing hair follicle stem cells can differentiate into neurons, Schwann cells, and other cell types. In the present study, nestin-expressing cells were located in the terminal end of hair follicle sensory nerve and peripheral nerves. Nestin-expressing cells proliferated in the injured nerves, the cells expressed neural axon marker and axon guidance factor. This phenomenon was observed not only in culture but in vivo study. Nestin-expressing cells appeared to play a major role in the recovery of peripheral nerve injury.
|
Report
(5 results)
Research Products
(6 results)
