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The study of mechanism of epidermotropism and metastasis of mycosis fungoides by establishing mouse mycosis fungoides model

Research Project

Project/Area Number 25860967
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Dermatology
Research InstitutionKeio University

Principal Investigator

FUKUDA Keitaro  慶應義塾大学, 医学部, 特任助教 (60464848)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords菌状息肉症 / Pautrier微小膿瘍 / 表皮抗原認識 / C-MYC / INK4A/ARF / 表皮向性 / 抗原特異性 / c-MYC / INK4a/ARF / IL-7 / 皮膚T細胞リンパ腫
Outline of Final Research Achievements

Mycosis fungoides (MF) is a cutaneous T cell lymphoma of CD4+ T cells that show epidermotropism. It is characterized by interface dermatitis (ID) and Pautrier's microabscess (PM), a clustering of MF cells in the epidermis. This project was conducted to establish MF model mouse that recapitulate histopathology of MF and to clarify the mechanism of the development of PM. Since mutation in INK4A/ARF (tumor suppressor gene) and overexpression of C-MYC (oncogene) are associated in human MF, we isolated CD4+T cells from Ink4/Arf-/- mice and retrovirally transduced c-Myc and desmoglein 3 specific TCR (H1) that induces ID. T cells were then adoptively transferred into Rag2-/- mice, which lead to the development of ID and PM that recapitulated MF. In addition, transfer of Ink4/Arf-/- CD4+T cells transduced with c-Myc developed PM whereas transfer of Ink4/Arf-/- CD4+T cells transduced with H1 did not develop PM. Our results suggest that oncogene c-Myc is essential for the development of PM.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) Book (1 results)

  • [Journal Article] IV期悪性黒色腫に対するカルボプラチン+パクリタキセル併用療法の救済療法としての有効性2014

    • Author(s)
      福田桂太郎、舩越 建、谷川瑛子、海老原 全、天谷雅行
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 124 Pages: 1555-1561

    • NAID

      130004588301

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Skin-infiltrating CD4+ lymphoma cells depend on hair follicle derived IL-72014

    • Author(s)
      Takeya Adachi, Tetsuro Kobayashi, Eiji Sugihara, Keitaro Fukuda, Hideyuki Saya, Taketo Yamada, Masayuki Amagai and Keisuke Nagao
    • Organizer
      The 39th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Osaka
    • Year and Date
      2014-12-12 – 2014-12-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Injury promotes melanoma metastasis via wound healing process with periostin2014

    • Author(s)
      Keitaro Fukuda, Eiji Sugihara, Shoichiro Ota, Kenji Izuhara, Masayuki Amagai, Hideyuki Saya
    • Organizer
      The 39th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Osaka
    • Year and Date
      2014-12-12 – 2014-12-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Injury promotes melanoma metastasis via periostin induced in wound healing process2014

    • Author(s)
      Keitaro Fukuda, Eiji Sugihara, Shoichiro Ota, Kenji Izuhara, Masayuki Amagai, Hideyuki Saya
    • Organizer
      The 73rd Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Book] 皮膚科臨床アセット17 皮膚の悪性腫瘍 実践に役立つ最新の診断・治療 29 鼻腔・副鼻腔悪性黒色腫2014

    • Author(s)
      福田桂太郎
    • Publisher
      中山書店
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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