| Project/Area Number |
25860972
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Research Collaborator |
YAMANISHI KIYOFUMI 兵庫医科大学, 医学部, 教授 (10182586)
IMAI YASUTOMO 兵庫医科大学, 医学部, 講師 (10529514)
HANEDA TAKASHI 兵庫医科大学, 医学部, 助教 (90580035)
TOMINAGA CHIHARU 兵庫医科大学, 医学部, 病院助手
SAKAGUCHI YOSHIKO 兵庫医科大学, 医学部, 実験補助
JITSUKAWA ORIE 兵庫医科大学, 医学部, 実験補助
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 乾癬 / 皮膚炎 / サイトカイン / 炎症性角化症 |
|---|
| Outline of Final Research Achievements |
Transgenic mice in which interleukin 36 gamma is over-expressed specifically in epidermis were generated. A mouse line, Il1f9tg, was established from those mice. When imiquimod was applied on the skin of Il1f9tg F1 mice, the cutaneous inflammation scores of those mice were exacerbated by about 20% in comparison with wild-type mice. In SPF condition, Il1f9tg mice developed no spontaneous eruption. Even in Il1f9tg mice crossed with Il33tg mice, which overexpresses IL-33 in the epidermis, showed no psoriasis-like inflammation of the skin. In addition, 11 patients with pustular psoriasis were subjected to analysis of IL36RN mutations. Of those, a known mutation in IL36RN was found in 2 cases including an oldest case ever reported.
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