Relationship between lupus band and anti-basement membrane antibodies in cutaneous lupus erythematosus
| Project/Area Number |
25860975
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ループスエリテマトーデス / 円盤状ループスエリテマトーデス / ループスバンドテスト / 基底膜 / 表皮 / 毛包上皮 / 免疫グロブリン / 水疱性類天疱瘡 / 補体 |
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| Outline of Final Research Achievements |
Although DIF has been generally performed in DLE (as lupus band test) and BP, contrasting features has not been reported. In some patients with lupus erythematosus, who have autoantibodies for BP, it may be difficult to discriminate LE from BP. We studied DIF of lesional skins in 9 patients with DLE and 29 patients with BP and disclosed the difference between these 2 diseases. IgG deposition was significantly more frequent at the epidermal BMZ in the BP group than in the DLE group; however, IgA and IgM depositions were significantly more frequent at both the epidermal and follicular BMZs in the DLE group than in the BP group.
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Report
(3 results)
Research Products
(7 results)
