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The fMRI study of reward system in the patient with major depressive disorder: Is the disturbance of the system a biological marker of treatment-resistant depression ?

Research Project

Project/Area Number 25860981
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionHokkaido University

Principal Investigator

HASHIMOTO Naoki  北海道大学, 医学(系)研究科(研究院), 客員研究員 (40615895)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsうつ病 / functional MRI / 報酬系 / 報酬予測課題 / 難治性うつ病 / ドパミン
Outline of Final Research Achievements

We scanned eleven normal subjects and eleven patients with major depressive disorder (MDD) using 1.5T MRI. In this analysis, the activation of the ventral striatum at high reward condition in MDD patients was significantly lower than that in normal control. We did not find any significant relationship between activity of ventral striatum and stress events nor temperament. After exchange of MRI scanner, we scanned 81 normal control subjects and find a significant higher activation at high reward condition in ventral striatum comparing to activation at no reward condition. Furthermore, we find (1) no smoking history, (2)higher TEMPS_anxiety, and (3) lower TEMPS_cyclothymic predict higher activation of ventral striatum. Now we are increasing a number of the subjects of patients with major depression and examining the relation ship between ventral striatum activation and treatment-resistant depression.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Neurocognitive impairments and quality of life in unemployed patients with remitted major depressive disorder.2013

    • Author(s)
      Shimizu Y, Kitagawa N, Mitsui N, Fujii Y, Toyomaki A, Hashimoto N, Kako Y, Tanaka T, Asakura S, Kusumi I
    • Journal Title

      Psychiatry Research

      Volume: 210 Issue: 3 Pages: 913-918

    • DOI

      10.1016/j.psychres.2013.08.030

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Severity of generalized social anxiety disorder correlates with low executive functioning.2013

    • Author(s)
      Fujii Y, Kitagawa N, Shimizu Y, Mitsui N, Toyomaki A, Hashimoto N, Kako Y, Tanaka T, Asakura S, Koyama T, Kusumi I.
    • Journal Title

      neuroscience letter

      Volume: 543 Pages: 42-46

    • DOI

      10.1016/j.neulet.2013.02.059

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suicide Intervention Skills Among Japanese Medical Residents.2013

    • Author(s)
      Fujisawa D, Suzuki, Y., Kato, A.T., Hashimoto, N., Sato, R., Aoyama-Uehara, K., Fukasawa, M., Tomita, M., Watanabe, K., Kashima, H., Otsuka, K.
    • Journal Title

      Academic Psychiatry

      Volume: 37 Issue: 6 Pages: 402-407

    • DOI

      10.1176/appi.ap.10110154

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Difference of reward system activation in patients with schizophrenia treated with olanzapine, blonanserine and aripiprazole-2nd report.2013

    • Author(s)
      Naoki Hashimoto, Atsuhito Toyomaki, Tamaki Miyamoto, Ichiro Kusumi.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      San Diego Convention Center (San Diego, USA)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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