• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of glutamate receptor GluD1 in synapse formation and emotion.

Research Project

Project/Area Number 25860982
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionHokkaido University

Principal Investigator

KONNO kohtarou  北海道大学, 医学(系)研究科(研究院), 助教 (20599641)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsグルタミン酸受容体
Outline of Final Research Achievements

Of the two members of the δ subfamily of ionotropic glutamate receptors, GluD2 is exclusively expressed in Purkinje cell and regulates their structural connectivity. However, little is known to date regarding cellular and synaptic expression of GluD1 and its role in synaptic circuit formation. GluD1 was widely expressed in the adult mouse brain. In the cerebellar cortex, GluD1 was concentrated at parallel fiber (PF) synapses on interneuron somata. In GluD1-knock-out mice, the density of PF synapses on interneuron somata was significantly reduced and the size and number of interneurons were significantly diminised. Therefore, GluD1 regulates the connectivity of PF-interneuron synapses and promotes the differentiation and/or survival of molecular layer interneurons. These results suggest that GluD1 works in concert with GluD2 for the construction of cerebellar synaptic wiring through distinct neuronal and synaptic expressions and also their shared synapse-connecting function.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results)

  • [Journal Article] Enriched Expression of GluD1 in Higher Brain Regions and Its Involvement in Parallel Fiber-Interneuron Synapse Formation in the Cerebellum.2014

    • Author(s)
      Konno K, Matsuda K, Nakamoto C, Uchigashima M, Miyazaki T, Yamasaki M, Sakimura K, Yuzaki M, Watanabe M.
    • Journal Title

      J Neurosci.

      Volume: 34(22) Issue: 22 Pages: 7412-24

    • DOI

      10.1523/jneurosci.0628-14.2014

    • NAID

      120005537463

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enriched expression of GluD1 in higher brain regions and its involvement in parallel fiber-interneuron synapse formation in the cerebellum.2014

    • Author(s)
      Konno K, Matsuda K, Nakamoto C, Uchigashima M, Miyazaki T, Yamasaki M, Sakimura K, Yuzaki M, Watanabe M
    • Journal Title

      The Journal of Neuroscience

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Input-selective expression of glutamate receptor GluD1 at ascending somatosensory pathway synapses in the ventral posteromedial thalamic nucleus.2015

    • Author(s)
      Kohtarou Konno, Koji Nishikawa, Masahiko Watanabe
    • Organizer
      第92回日本生理学会・第120回日本解剖学会・全国学術集会
    • Place of Presentation
      神戸国際会議場(神奈川県・神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Enriched expression of GluD1 in higher brain regions and its involvement in parallel fiber-interneuron synapse formation in the cerebellum.2014

    • Author(s)
      Kohtarou Konno, Keiko Matsuda, Chihiro Nakamoto, Kenji Sakimura, Michisuke Yuzaki, Masahiko Watanabe
    • Organizer
      Neuroscience 2014 Annual Meeting
    • Place of Presentation
      Washington DC (USA)
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Selective expression of glutamate receptor GluD1 at ascending pathway synapses in thalamic neurons of the ventral posteromedial nucleus.2014

    • Author(s)
      Kohtarou Konno, Koji Nishikawa, Masahiko Watanabe
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] グルタミン酸受容体GluD1の細胞選択的・シナプス選択的発現およびシナプス形成作用2014

    • Author(s)
      今野幸太郎、柚崎通介、渡辺雅彦
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学(栃木)
    • Related Report
      2013 Research-status Report
  • [Presentation] Distinct cellular, subcellular, and synaptic expressions of Glutamate receptor GluD1 in adult mouse brain2013

    • Author(s)
      Konno K, Nakamoto C, Matsuda K, Sakimura K, Yuzaki M, Watanabe M
    • Organizer
      日本神経科学大会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Research-status Report
  • [Presentation] マウス脳におけるグルタミン酸受容体GluD1の細胞選択的およびシナプス選択的発現2013

    • Author(s)
      今野幸太郎、柚崎通介、渡辺雅彦
    • Organizer
      日本解剖学会 第59回東北・北海道連合支部学術集会
    • Place of Presentation
      北海道大学大学(北海道)
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi