Evaluation of involvement of anti-aquaporin 4 and CSF histamin levels in secondary hypersomnia
| Project/Area Number |
25860985
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Akita University |
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Principal Investigator |
SAGAWA Yohei 秋田大学, 医学(系)研究科(研究院), 助教 (10637565)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ナルコレプシー / オレキシン / アクアポリン４ / ヒスタミン / アクアポリン4 |
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| Outline of Final Research Achievements |
(1) We examined the clinical symptoms and CSF orexin levels in the secondary hypersomnia that have a lesion in the hypothalamus. CSF orexin levels of all cases in this study were low or intermediate values. Then in all case, CSF orexin levels were recovered to normal level after treatment.Since AQP4 is highly expressed in the hypothalamic periventricular regions, an immune attack on AQP4 may be partially responsible for the bilateral and hypothalamic lesions and orexin deficiency in narcolepsy/EDS associated with autoimmune demyelinating diseases.
(2) We have further estimated the histamine in CSF of several neurological diseases such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Average histamine value was low in PSP and CBD compared to the MSA. This may suggest that the hypersomnia symptom in PSP is more severe compared to the MSA.
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Report
(3 results)
Research Products
(17 results)
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[Presentation] CSF NEUROENDOCRINE REGULATORY PEPTIDE (NERP)-2 LEVELS ARE POSITIVELY CORRELATED WITH OREXIN (HYPOCRETIN) LEVELS.2014
Author(s)
Kanbayashi T, Imanishi A, Sagawa Y, Inomata Y, Uemura-Ito S, Sato M, Takeshima M, Suzuki R, Nishino S, Shimizu T
Organizer
the 28th Annual Meeting of the APSS
Place of Presentation
Minneapolis, MN
Year and Date
2014-05-31 – 2014-06-04
Related Report
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[Presentation] SYMPTOMATIC NARCOLEPSY AMONG INHERITED DISORDERS, SUCH AS NIEMANN-PICK TYPE C AND MYOTONIC DYSTROPHY TYPE 12014
Author(s)
Imanishi A, Kanbayashi T, Shimohata T, Sagawa Y, Takahashi Y, Suda H, Takahashi J, Kubota H, Kikuchi Y, Shimizu T
Organizer
the 28th Annual Meeting of the APSS
Place of Presentation
Minneapolis, MN
Year and Date
2014-05-31 – 2014-06-04
Related Report
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[Presentation] CSF QRFP CONCENTRATIONS IN NARCOLEPSY, NEUROLOGICAL AND PSYCHIATRIC DISORDERS2013
Author(s)
Kanbayashi, T., Sagawa, Y., Imanishi, A., Takahashi, Y., Suda, H., Takahashi, J., Tokunaga, J., Sato, M., Sato, S., Shimizu
Organizer
The 27th Annual Meeting of the Associated Professional Sleep Societies
Place of Presentation
Baltimore, USA
Related Report
