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Research association between dysfunction of sensory gating and pathophysiology of psychiatric disorders

Research Project

Project/Area Number 25860988
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionChiba University

Principal Investigator

Hashimoto Tasuku  千葉大学, 大学院医学研究院, 講師 (60396679)

Research Collaborator SATO Aiko  千葉大学, 大学院医学研究院, 大学院生
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords感覚ゲート機構 / 聴覚誘発電位P50抑制 / 不安障害 / パニック障害 / うつ病 / 双極性障害 / sensory gating / 気分障害 / パニック症 / P50 / バイオマーカー / Sensory Gating / 聴覚誘発電位 / P50抑制
Outline of Final Research Achievements

Sensory gating is one of the brain information processing systems and regulates enormous sensory input to the brain. P50 inhibition is assessed by recording P50, which is a positive wave peaking between 40 and 75 ms following auditory stimulus presentation, in response to two paired auditory stimuli, and is assumed to reflect sensory gating.
The aim of the present study was to examine the association between dysfunction of sensory gating and the pathophysiology of psychiatric disorders such as panic disorder. The main result was that anxiety-related core symptoms, anxiety, fear and tension of the subcategories of the Hamilton Anxiety Rating Scale (HAM-A) were not significant but showed a trend of positive correlation with P50 test/condition ratio in patients with panic disorder (Pearson's r = 0.340, p = 0.083). This finding implicated that dysfunction of sensory gating might contribute to the pathophysiology of anxiety.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (3 results)

All 2017 2016 2014

All Presentation (3 results)

  • [Presentation] パニック障害における事象関連電位P50 抑制と不安症状の相関解析研究2017

    • Author(s)
      橋本佐、佐藤愛子、伊豫雅臣
    • Organizer
      東京精神医学会
    • Place of Presentation
      ステーションコンファレンス東京 402ABCD
    • Year and Date
      2017-03-11
    • Related Report
      2016 Annual Research Report
  • [Presentation] パニック障害における聴覚誘発電位P50抑制と不安症状の相関解析研究2016

    • Author(s)
      佐藤愛子
    • Organizer
      第127回日本心身医学会関東地方会
    • Place of Presentation
      東邦大学医療センター大森病院5号館
    • Year and Date
      2016-02-13
    • Related Report
      2015 Research-status Report
  • [Presentation] Event-related potential P50 suppression as common end-phenotype of psychiatric disorders2014

    • Author(s)
      Hata,T. Hashimoto, K. Yoshimura, M. Koseki, A. Okato,Y. Mori, K. Hashimoto, M. Iyo
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      International Conference Center, Kyoto
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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