The analyses of altered neural oscillations in schizophrenia

• Project/Area Number: 25860990
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: KIRIHARA Kenji 東京大学, 医学部附属病院, 助教 (80553700)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 神経オシレーション / ミスマッチ陰性電位 / 脳波 / 統合失調症 / 臨床病期

Outline of Final Research Achievements

The objective of this study is to investigate neural activity in early stages of schizophrenia. We recorded electroencephalography in patients with first-episode schizophrenia, individuals at ultra-high risk, and healthy control subjects. We found reduction of mismatch negativity amplitude and alterations of neural oscillations in early stages of schizophrenia. These findings suggest that mismatch negativity and neural oscillations may be useful biomarkers for early stages of schizophrenia.

Research Products

• [Journal Article] Mismatch negativity as a “translatable” brain marker toward early intervention for psychosis: a review. (2013)
  • Author(s): Nagai T, Tada M, Kirihara K, Araki T, Jinde S, Kasai K.
  • Journal Title: Front. Psychiatry Volume: 115 Pages: 1-10
  • DOI: 10.3389/fpsyt.2013.00115
  • Peer Reviewed
• [Journal Article] Auditory mismatch negativity and P3a in response to duration and frequency changes in the early stages of psychosis. (2013)
  • Author(s): Nagai T, Tada M, Kirihara K, Yahata N, Hashimoto R, Araki T, Kasai K.
  • Journal Title: Schizophr Res Volume: 150 Issue: 2-3 Pages: 547-54
  • DOI: 10.1016/j.schres.2013.08.005
  • Peer Reviewed
• [Journal Article] 統合失調症の治療ゴール true endpointとsurrogate endpoint (2013)
  • Author(s): 越山 太輔, 切原 賢治, 笠井 清登
  • Journal Title: Progress in Medicine Volume: 33 Pages: 2361-2365
• [Presentation] 統合失調症における神経オシレーションの同期と相互作用の変化 (2015)
  • Author(s): 切原賢治、多田真理子、永井達哉、越山太輔、荒木剛、笠井清登
  • Organizer: 第45回日本臨床神経生理学会学術大会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2015-11-07
• [Presentation] 統合失調症におけるミスマッチ陰性電位 (2014)
  • Author(s): 切原賢治、永井達哉、多田真理子、越山太輔、荒木剛、笠井清登
  • Organizer: 第44回日本臨床神経生理学会学術大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2014-11-20
• [Presentation] Impaired neural synchrony during gaze processing in schizophrenia.
  • Author(s): Kenji Kirihara, Tsuyoshi Araki, Mariko Tada, Tatsuya Nagai, Kiyoto Kasai.
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: 国立京都国際会館（京都府京都市）
• [Presentation] Impaired neural synchrony during gaze processing in schizophrenia.
  • Author(s): Kenji Kirihara.
  • Organizer: Neural Oscillation Conference 2013
  • Place of Presentation: 自然科学研究機構岡崎コンファレンスセンター（愛知県岡崎市）