| Project/Area Number |
25860991
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Uezato Akihito 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (90547449)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 死後脳 / 遺伝子 / 精神疾患 / 遺伝子発現 / 発達依存性 |
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| Outline of Final Research Achievements |
In mental diseases with post-adolescent onset, a dysfunction of neural circuits that mature during adolescence or alterations of the related molecules and genes are speculated. We found the expression of synapse-associated protein 97 (SAP97) increased only after a developmental critical period in response to NMDA receptor blocker administration, therefore, SAP97 gene was regarded as development-dependent risk gene of schizophrenia. The mRNA expression analysis of SAP97 new splicing variant in postmortem brains of schizophrenia revealed the reduced expression in early-onset schizophrenia, indicating its involvement in the disease development process.
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