The role of the Interleukin 1 in pathophysiology of schizophrenia

• Project/Area Number: 25860992
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Niigata University
• Principal Investigator: SHIBUYA MASAKO 新潟大学, 保健管理センター, 講師 (70631620)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: インターロイキン1 / 統合失調症 / 関連解析 / メタ解析 / インターロイキン１ / リシークエンス

Outline of Final Research Achievements

To assess whether the Interleukin 1 beta (IL1) gene confers increased susceptibility to schizophrenia, we conducted case-control and family-based studies and an updated meta-analysis. We tested the association between IL1B and schizophrenia in 1229 case-control and 112 trio samples using 12 markers. We also performed a meta-analysis of rs16944 using a total of 8724 case-control and 201 trio samples. We found no significant associations between any of the 12 markers examined and schizophrenia in either case-control or trio samples. Moreover, our meta-analysis results showed no significant association between rs16944 and schizophrenia. Our results suggest that IL1B does not confer increased susceptibility to schizophrenia.

Research Products

• [Journal Article] DRD2 Ser311Cys polymorphism and risk of schizophrenia. (2015)
  • Author(s): Watanabe, Y., Shibuya, M., Someya, T.
  • Journal Title: American Journal of Medical Genetics. Part G, Neuropsychiatric Genetics Volume: 168 Issue: 3 Pages: 224-228
  • DOI: 10.1002/ajmg.b.32303
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The cardiomyopathy-associated 5 (CMYA5) gene and risk of schizophrenia: Meta-analysis of rs3828611 and rs4704591 in East Asian populations (2014)
  • Author(s): Watanabe, Y., Shibuya, M., Someya, T.
  • Journal Title: Asian Journal of Psychiatry Volume: ７ Pages: 95-96
  • DOI: 10.1016/j.ajp.2013.10.013
  • Peer Reviewed
• [Journal Article] A rare MIR138-2 gene variation is associated with schizophrenia in a Japanese population (2014)
  • Author(s): Watanabe, Y., Hishimoto, A., Shibuya, M., Nunokawa, A., Kaneko, N., Igeta, Egawa, J., Mouri, K., Sora, I., Someya, T.
  • Journal Title: Psychiatry Research Volume: 215 Issue: 3 Pages: 801-802
  • DOI: 10.1016/j.psychres.2013.12.029
  • Peer Reviewed
• [Journal Article] Association analysis of putative cis-acting polymorphisms of interleukin-19 gene with schizophrenia (2014)
  • Author(s): Okazaki, S., Watanabe, Y., Hishimoto, A., Sasada, T., Mouri, K., Shiroiwa, K., Eguchi, N., Ratta-Apha, W., Otsuka, I., Nunokawa, A., Kaneko, N., Shibnuya. M., Someya, T., Shirakawa, O., Sora, I.
  • Journal Title: Progress in Neuro-Psychopharmacology & Biological Psychiatry Volume: 50 Pages: 151-156
  • DOI: 10.1016/j.pnpbp.2013.12.006
  • Peer Reviewed
• [Journal Article] Interleukin 1 beta gene and risk of schizophrenia : detailed case-control and family-based studies and an updated meta-analysis (2014)
  • Author(s): Shibuya, M., Watanabe, Y., Nunokawa, A., Egawa, J., Kaneko, N., Igeta, H., Someya, T.
  • Journal Title: Human Psychopharmacology : Clinical and Experimental Volume: 29 Issue: 1 Pages: 31-37
  • DOI: 10.1002/hup.2365
  • Peer Reviewed
• [Presentation] インターロイキン１ベータ遺伝子と統合失調症との関連研究 (2014)
  • Author(s): 澁谷雅子、渡部雄一郎、布川綾子、江川純、金子尚史、井桁裕文、染矢俊幸
  • Organizer: 第36回日本生物学的精神医学会
  • Place of Presentation: 奈良県文化会館
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] TPH2遺伝子と日本人統合失調症との2段階関連解析 (2014)
  • Author(s): 布川綾子, 渡部雄一郎, 飯嶋良味, 江川純, 金子尚史, 澁谷雅子, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 栃木衛, 功刀浩, 糸川昌成, 尾崎紀夫, 橋本亮太, 染矢俊幸
  • Organizer: 第36回日本生物学的精神医学会
  • Place of Presentation: 奈良県文化会館
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] マイクロRNA138-2遺伝子の稀な変異と統合失調症との関連 (2014)
  • Author(s): 渡部雄一郎, 菱本明豊, 澁谷雅子, 布川綾子, 金子尚史, 井桁裕文, 江川純, 毛利健太朗, 曽良一郎, 染矢俊幸
  • Organizer: 第36回日本生物学的精神医学会
  • Place of Presentation: 奈良県文化会館
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] マイクロRNA137遺伝子のリシーケンスおよび統合失調症との関連解析 (2014)
  • Author(s): 井上絵美子, 江川純, 布川綾子, 澁谷雅子, 渡部雄一郎, 金子尚史, 井桁裕文, 染矢俊幸
  • Organizer: 第36回日本生物学的精神医学会
  • Place of Presentation: 奈良県文化会館
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] 統合失調症とHLA-DRB1*01およびHLA-DRB1*04の遺伝子関連解析 (2014)
  • Author(s): 岡﨑賢志, 菱本明豊, 渡部雄一郎, ラッターアーパーウォラパット, 毛利健太朗, 白岩恭一, 笹田徹, 江口典臣, 大塚郁夫, 布川綾子, 澁谷雅子, 染矢俊幸, 曽良一郎
  • Organizer: 第36回日本生物学的精神医学会
  • Place of Presentation: 奈良県文化会館
  • Year and Date: 2014-09-29 – 2014-10-01
• [Presentation] マイクロRNA30E遺伝子の稀な変異と統合失調症との関連 (2014)
  • Author(s): 江川純, 飯嶋良味, 渡部雄一郎, 布川綾子, 金子尚史, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 功刀浩, 糸川昌成, 佐々木司, 尾崎紀夫, 橋本亮太, 澁谷雅子, 井桁裕文, 染矢俊幸
  • Organizer: 第36回日本生物学的精神医学会
  • Place of Presentation: 奈良県文化会館
  • Year and Date: 2014-09-29 – 2014-10-01