| Project/Area Number |
25860994
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Kanazawa University |
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Principal Investigator |
IGUCHI Yoshio 金沢大学, 医学系, 博士研究員 (20452097)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | うつ病 / 慢性ストレス / ストレス反応性 / 個体差 / 意欲 / 柔軟な意思決定 / 欲求性オペラント学習 / 側坐核 / 大うつ病 / 欲求性の道具的学習 / 意思決定の柔軟性 / ストレス脆弱性 / SSRI反応性 / 意思決定 / 中脳辺縁ドパミン系 / ラット |
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| Outline of Final Research Achievements |
Although chronic stress has been widely used to induce depression-like phenotypes in preclinical studies, a few models have been developed to study causal relationship between the individual differences in the depression-like phenotypes and the pre-existing individual differences prior to stress exposure, which might genetically/epigenetically determine the fate of each animal after stress. We focused on a large inter-individual variability of a group of outbred rats in performance of an appetitive operant (leverpress) trained on a progressive ratio (PR) schedule. Based on the PR performance, we classified animals into 4 subgroups, which were found to show distinctive cognitive/behavioral characteristics. Moreover, the 4 subgroups revealed different behavioral responses to a chronic unpredictable stress (CUS) on short- and long-term bases. These results suggest that the individual differences in the pre-CUS PR performance can predict the distinctive post-CUS behavioral phenotypes.
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