Pre-stress performance in an operant learning predicts post-stress behavioral alterations in chronically stressed rats

• Project/Area Number: 25860994
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Kanazawa University
• Principal Investigator: IGUCHI Yoshio 金沢大学, 医学系, 博士研究員 (20452097)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: うつ病 / 慢性ストレス / ストレス反応性 / 個体差 / 意欲 / 柔軟な意思決定 / 欲求性オペラント学習 / 側坐核 / 大うつ病 / 欲求性の道具的学習 / 意思決定の柔軟性 / ストレス脆弱性 / SSRI反応性 / 意思決定 / 中脳辺縁ドパミン系 / ラット

Outline of Final Research Achievements

Although chronic stress has been widely used to induce depression-like phenotypes in preclinical studies, a few models have been developed to study causal relationship between the individual differences in the depression-like phenotypes and the pre-existing individual differences prior to stress exposure, which might genetically/epigenetically determine the fate of each animal after stress. We focused on a large inter-individual variability of a group of outbred rats in performance of an appetitive operant (leverpress) trained on a progressive ratio (PR) schedule. Based on the PR performance, we classified animals into 4 subgroups, which were found to show distinctive cognitive/behavioral characteristics. Moreover, the 4 subgroups revealed different behavioral responses to a chronic unpredictable stress (CUS) on short- and long-term bases. These results suggest that the individual differences in the pre-CUS PR performance can predict the distinctive post-CUS behavioral phenotypes.

Research Products

• [Journal Article] Pre-stress performance in an instrumental training predict post-stress behavioral alterations in chronically stressed rats (2015)
  • Author(s): Iguchi, Y., Kosugi, S., Lin, Z., Nishikawa, H., Minabe, Y., & Toda, S.
  • Journal Title: Frontiers in Behavioral Neuroscience Volume: 印刷中
  • NAID: 120006027759
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Repeated exposure of adult rats to transient oxidative stress induces various long-lasting alterations in cognitive and behavioral functions. (2014)
  • Author(s): Iguchi Y, Kosugi S, Nishikawa H, Lin Z, Minabe Y, Toda S.
  • Journal Title: PloS One Volume: 9 Issue: 12 Pages: e114024-e114024
  • DOI: 10.1371/journal.pone.0114024
  • NAID: 120006027760
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Facilitated or delayed habit formation of appetitive instrumental learning in each subject of Sprague-Dawley rats (2014)
  • Author(s): Iguchi, Y., Lin, Z., Nishikawa, H., Minabe, Y., & Toda, S.
  • Organizer: The 8th research area meeting Grant-in-Aid for Scientific Research on Innovative Areas: Elucidation of the Neural Computation for Prediction and Decision Making
  • Place of Presentation: Tokyo Medical and Dental University, Tokyo, Japan
  • Year and Date: 2014-12-11
• [Presentation] Repeated mild oxidative stress favors habits over goal-directed action in instrumental learning: Effects of 2-cyclohexne-1-one on behaviors associated with the dopaminergic system in rats (2014)
  • Author(s): Iguchi, Y., Lin, A., Nishikawa, H., Kosugi, S., Minabe, Y., & Toda, S.
  • Organizer: The 74th annual meeting of Japanese society for animal psychology
  • Place of Presentation: Inuyama international sightseeing center (FREUDE) Aichi, Japan
  • Year and Date: 2014-07-19 – 2014-07-21
• [Presentation] Individual differences in pre-stress state predict distinct responses to chronic unpredictable stress in rats (2014)
  • Author(s): Iguchi, Y., Kosugi, S., Minabe, Y., & Toda, S.
  • Organizer: The 7th research area meeting Grant-in-Aid for Scientific Research on Innovative Areas: Elucidation of the Neural Computation for Prediction and Decision Making
  • Place of Presentation: Media Center & Kyushu Institute of Technology, Fukuoka, Japan
  • Year and Date: 2014-06-06 – 2014-06-08
• [Presentation] コカイン行動感作形成における酸化ストレスの役割 (2014)
  • Author(s): 井口善生・戸田重誠
  • Organizer: 新学術領域「マイクロ精神病態」若手交流研究会
  • Place of Presentation: 磯部ガーデン, 群馬
• [Presentation] 意思決定スタイルの個体差を用いたストレス反応性の予測 (2014)
  • Author(s): 井口善生
  • Organizer: 金沢認知科学シンポジウム2014, 「言語・コミュニケーションの諸相―発達と障害―」
  • Place of Presentation: 金沢大学(角間キャンパス), 石川
• [Presentation] Individual differences in instrumental performance in naïve rats predict distinctive response to chronic unpredictable stress. (2013)
  • Author(s): Iguchi, Y., Kosugi, S., Minabe, Y., & Toda, S.
  • Organizer: The 6th MCCS (Molecular Cellular Cognition Society) Asia Symposium
  • Place of Presentation: 京都国際会議場, 京都
• [Presentation] Dissociable effects of a glutathione synthesis inhibitor on locomotor activity and stereotypy of cocaine sensitization. (2013)
  • Author(s): Toda, S., Kosugi, S., Iguchi, Y., & Minave, Y.
  • Organizer: Neuro2013 (The 36th annual meeting of the Japan neuroscience society)
  • Place of Presentation: 京都国際会議場, 京都
• [Presentation] Individual differences in instrumental performance in naive rats predict distinctive responses to chronic unpredictable stress. (2013)
  • Author(s): Iguchi, Y., Kosugi, S., Minabe, Y., & Toda, S.
  • Organizer: Neuro2013 (The 36th annual meeting of the Japan neuroscience society)
  • Place of Presentation: 京都国際会議場, 京都
• [Presentation] Indivisual differences in instrumental performance in naïve rats predicts distinctive responses to chronic stress. (2013)
  • Author(s): Iguchi, Y.
  • Organizer: 新学術領域「マイクロ精神病態」班会議
  • Place of Presentation: ホテル名古屋ガーデンパレス, 愛知
• [Presentation] 道具的行動の遂行パタンの個体差は短期的/ 長期的な慢性ストレス反応性の違いを予測する (2013)
  • Author(s): 井口善生・小杉桜子・三邉義雄・戸田重誠.
  • Organizer: 第22回海馬と高次脳機能学会
  • Place of Presentation: 湯涌創作の森, 石川
• [Presentation] Individual differences in pre-stress state predict distinct responses to chronic unpredictable stress in rats (2013)
  • Author(s): Iguchi, Y., Kosugi, S., Minabe, Y., & Toda, S.
  • Organizer: 12th Annual MCCS Meeting
  • Place of Presentation: Westin Gaslamp Quarter Hotel, Garden Terrace/SD Ballroom, San Diego, CA, USA.
• [Presentation] emporal and persistent effects of mild oxidative stress on striatum-dependent behaviors in rats. (2013)
  • Author(s): Toda, S., Kosugi, S., Iguchi, Y., & Minabe, Y.
  • Organizer: 43th Annual Meeting of Society for Neuroscience (Neuroscience 2013)
  • Place of Presentation: San Diego Convention Center, San Diego, CA, USA.
• [Presentation] Individual differences in pre-stress state predict distinct responses to chronic unpredictable stress in rats. (2013)
  • Author(s): Iguchi, Y., Kosugi, S., Minabe, Y., & Toda, S.
  • Organizer: 43th Annual Meeting of Society for Neuroscience (Neuroscience 2013)
  • Place of Presentation: San Diego Convention Center, San Diego, CA, USA.