Effect of aripiprazole for the treatment of comorbidity of ASDsubjects: investigation from executive function.
Project/Area Number |
25860996
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | National Center of Neurology and Psychiatry |
Principal Investigator |
ISHITOBI Makoto 独立行政法人国立精神・神経医療研究センター, 精神保健研究所 児童・思春期精神保健研究部, 室長 (50464053)
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 自閉症スペクトラム障害 / 併存症 / aripiprazole / 二次障害 / 非定型抗精神病薬 / 実行機能 |
Outline of Final Research Achievements |
Despite of wide use of aripiprazole for the treatment of irritability ofASD subjectsits’ in Japan, there are few reports about the effects of aripiprazole for ASD subjects. In addition, the mechanism of aripiprazole behind the improvement of irritability symptoms is not clear. We examined the efficacy and the tolerability of lower-dose aripiprazole compared to that was used in previous studies for treating behavioral problems of 29 antipsychotics naive subjects with ASD and showed that low dose aripiprazole may be effective and well tolerated for irritability in subjects with ASD. In order to investigate the effects of aripiprazole to ASD subjects, we did preliminary study to investigate the effects of anti-ADHD medication to subjects with ASD and ADHD using executive function test and NIRS measurement. We showed that NIRS measurements might be useful for assessing the psychological effects of MPH even when performance changes were not observed in the cognitive tasks.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Attenuation of the contingency detection effect in the extrastriate body area in Autism Spectrum Disorder.2014
Author(s)
Yuko Okamoto., Ryo Kitada., Hiroki C. Tanabe., Masamichi J. Hayashi., Takanori Kochiyama., Toshio Munesue.,Makoto Ishitobi., Daisuke N. Saito., Hisakazu T. Yanaka., Masao Omori., Yuji Wada., Hidehiko Okazawa., Akihiro T. Sasaki., Tomoyo Morita., Shoji Itakura., Hirotaka Kosaka., Norihiro Sadato.
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Journal Title
Neuroscience Research.
Volume: 87
Related Report
Peer Reviewed
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[Journal Article] Distinguishing between autism spectrum disorder and attention deficit hyperactivity disorder by using behavioral checklists, cognitive assessments, and neuropsychological test battery.2014
Author(s)
Naomi Matsuura., Makoto Ishitobi., Sumiyoshi Arai., Kaori Kawamura., Mizuki Asano., Keisuke Inohara., Tadamasa Narimoto.,Yuji Wada., Michio Hiratani., Hirotaka Kosaka
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Journal Title
Asian Journal of Psychiatry.
Volume: 12
Pages: 50-57
Related Report
Peer Reviewed
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[Presentation] Effects of Methylphenidate in Children with attention deficit hyperactivity disorder: A Near-Infrared Spectroscopy Study using CANTAB®2014
Author(s)
Sumiyoshi Arai, Naomi Matsuura, Keisuke Inohara, Toru Fujioka, Makoto Ishitobi, Mizuki Asano, Kaori Kawamura, Minyoung Jung, Yuji Wada, Akemi Tomoda, Michio Hiratani, Hirotaka Kosaka
Organizer
International Workshop for Molecular Functional Imaging-Brain and Gynecologic Oncology-
Place of Presentation
ユアーズホテルフクイ
Related Report
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[Presentation] Effects of Methylphenidate on Neuropsychological Performance in Children with ADHD Using the Cambridge Neuropsychological Test Automated Battery (CANTAB®)2014
Author(s)
Sumiyoshi Arai, Naomi Matsuura, Keisuke Inohara, Toru Fujioka, Makoto Ishitobi, Mizuki Asano, Kaori Kawamura, Minyoung Jung, Yuji Wada, Akemi Tomoda, Michio Hiratani, Hirotaka Kosaka
Organizer
The 2nd Asian Congress on ADHD Jointly with The 5th Annual Meeting of Japanese Society of ADHD
Place of Presentation
東京医科大学病院
Related Report