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The role of cytokines in the pathophysiology of autism and depression

Research Project

Project/Area Number 25860997
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionShinshu University

Principal Investigator

SASAYAMA Daimei  信州大学, 学術研究院医学系, 助教 (90447764)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords自閉症スペクトラム / サイトカイン / 認知機能 / うつ病 / autism spectrum disorder / cytokine / depression
Outline of Final Research Achievements

Evidence indicates that immune system and nervous system reciprocally regulate each other through cytokines. Previous reports have shown that some cytokines are increased in patients with autism spectrum disorder (ASD). In the present study, we showed that children with ASD who had higher blood levels of interleukin-6 (IL-6) had lower verbal comprehension scores. This finding suggests the possibility that IL-6 may play a role in the impairment of cognitive development in those with ASD.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] ITIH3 polymorphism may confer susceptibility to psychiatric disorders by altering the expression levels of GLT8D12014

    • Author(s)
      Sasayama D, Hori H, Yamamoto N, Nakamura S, Teraishi T, Tatsumi M, Hattori K, Ota M, Higuchi T, Kunugi H
    • Journal Title

      Journal of Psychiatric Research

      Volume: 50 Issue: 1 Pages: 79

    • DOI

      10.1016/j.jpsychires.2013.12.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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