Analysis of molecular pathophysiology of gender identity disorder using microarray method

• Project/Area Number: 25861007
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Okayama University
• Principal Investigator: OKAHISA YUKO 岡山大学, 大学病院, 助教 (90583097)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 性同一性障害 / ジャポニカアレイ / マイクロアレイ / 臨床精神分子遺伝学

Outline of Final Research Achievements

The purpose of this study is to reveal the molecular pathophysiology of gender identity disorder. We conducted whole-genome analysis of 96 female-to-male trans-sexual individuals using Japonica array but failed to identify pathogenesis of gender identity disorder. We intend to perform genotype imputation analysis in further study.

Research Products

• [Journal Article] Human Rho guanine nucleotide exchange factor 11 gene is associated with schizophrenia in a Japanese population. (2014)
  • Author(s): Mizuki Y, Takaki M, Okahisa Y, Sakamoto S, Kodama M, Ujike H, Uchitomi Y.
  • Journal Title: Hum Psychopharmacol. Volume: 29 Issue: 6 Pages: 552-558
  • DOI: 10.1002/hup.2435
  • NAID: 120005549935
  • Peer Reviewed
• [Journal Article] Four polymorphisms of the pericentriolar material 1 (PCM1) gene are not associated with schizophrenia in a Japanese population. (2014)
  • Author(s): Sakamoto S, Takaki M, Okahisa Y, Mizuki Y, Kodama M, Ujike H, Uchitomi Y.
  • Journal Title: Psychiatry Res. Volume: 216 Issue: 2 Pages: 288-289
  • DOI: 10.1016/j.psychres.2014.02.006
  • NAID: 120006323726
  • Peer Reviewed
• [Journal Article] Association Study of Dopamine β-Hydroxylase Gene with Methamphetamine Psychosis (2014)
  • Author(s): Okahisa Y, Ujike H, Takaki M, Mizuki Y, Sakamoto S, Won M, Kondo N, Naruse N, Aoyama-Uehara K, Iwata N, Iyo M, Sora I, Ozaki N, Uchitomi Y
  • Journal Title: Journal of Drug and Alcohol Research. Volume: 3 Pages: 1-6
  • DOI: 10.4303/jdar/235792
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 非鎮静系抗精神病薬aripiprazole、blonanserinの適応外使用の状況と理由の検討 (2014)
  • Author(s): 高木学, 北川航平, 江角悟, 水木寛, 酒本真次, 藤原雅樹, 岡久祐子, 井上真一郎, 児玉匡史, 岡部伸幸, 寺田整司, 内富庸介
  • Journal Title: 臨床精神薬理 Volume: 17（3） Pages: 375-388
  • Peer Reviewed
• [Journal Article] Measurement and treatment research to improve cognition in schizophrenia consensus cognitive battery. (2013)
  • Author(s): Kaneda Y, Ohmori T, Okahisa Y, Sumiyoshi T, Pu S, Ueoka Y,Takaki M,Nakagome K, Sora I
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 67(3) Issue: 3 Pages: 182-188
  • DOI: 10.1111/pcn.12029
  • Peer Reviewed
• [Journal Article] Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia (2013)
  • Author(s): 池田 匡志 他
  • Journal Title: Neuropsychopharmacology Volume: 38 Issue: 10 Pages: 1864-1870
  • DOI: 10.1038/npp.2013.94
  • Peer Reviewed
• [Journal Article] Adjunctive yokukansan treatment improved cognitive functions in a patient with schizophrenia. (2013)
  • Author(s): Sakamoto S, Ujike H, Takaki M, Mizuki Y, Okahisa Y, Kodama M, Uchitomi Y.
  • Journal Title: J Neuropsychiatry Clin Neurosci. Volume: 25 Issue: 3 Pages: 39-40
  • DOI: 10.1176/appi.neuropsych.12070166
  • Peer Reviewed
• [Journal Article] Association Study of FYN Gene Polymorphism and Methamphetamine Use Disorder (2013)
  • Author(s): Sakamoto S, Okahisa Y, Takaki M, Mizuki Y, Kodama M, Aoyama-Uehara K, Won M, Kondo N, Naruse N, Sora I, Iwata N, Iyo M, Ozaki N, Ujike H, Uchitomi Y
  • Journal Title: Journal of Drug and Alcohol Research Volume: 2 Pages: 1-6
  • DOI: 10.4303/jdar/235790
  • Peer Reviewed
• [Journal Article] 統合失調症認知機能簡易評価尺度日本語版(BACS-J)標準化の試み (2013)
  • Author(s): 兼田康宏, 住吉太幹, 中込和幸, 池澤聰, 大森哲郎, 古郡規雄, 功刀浩, 松尾淳子, 宮本聖也, 中村純, 久住一郎, 岡久祐子ら
  • Journal Title: 精神医学 Volume: 55（2） Pages: 167-175
  • Peer Reviewed
• [Journal Article] 薬の使い方シリーズ Blonanserinを使いこなす(第9回) 統合失調症治療におけるblonanserinへの期待 高プロラクチン血症を中心に (2013)
  • Author(s): 岡久祐子，髙木学
  • Journal Title: 臨床精神薬理 Volume: 16（9） Pages: 1385-1391
  • Peer Reviewed
• [Presentation] Expression profiles as a predictive biomarker of schizophrenia (2014)
  • Author(s): Okahisa Y, Ikeda M, Takaki M, Sakamoto S, Ujike H, Iwata N, Uchitomi Y.
  • Organizer: XXIIND World Congress of Psychiatric Genetics
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2014-10-12 – 2014-10-16
• [Presentation] The UCSD Performance-based Skilles Assessment-brief Japanese Version (UPSA-B_J): Discriminative Validity for Schizophrenia (2014)
  • Author(s): Sumiyoshi C, Takaki M, Okahisa Y, Patterson T, Harvey P, Sumiyoshi T
  • Organizer: 4Th Schizophrenia International Research Society Conference
  • Place of Presentation: Florence, Italy
  • Year and Date: 2014-04-05 – 2014-04-09
• [Presentation] Association study of dopamine β-hydroxylase gene with methamphetamine dependence (2013)
  • Author(s): Okahisa Y, Ujike H, Sakamoto S, Mizuki Y, Takaki M, Won M, Kondo N, Naruse N, Aoyama-Uehara K, Iwata N, Iyo M, Sora I, Ozaki N, Uchitomi Y
  • Organizer: 4th International Drug Abuse Research Society Meeting
  • Place of Presentation: Mexico City, Mexico
• [Presentation] Association between the Fyn kinase gene and patients with methamphetamine dependence (2013)
  • Author(s): Sakamoto S, Okahisa Y, Takaki M, Mizuki Y, Kodama M, Aoyama-Uehara K, Won M, Kondo N, Naruse N, Sora I, Iwata N, Iyo M, Ozaki N, Ujike H, Uchitomi Y
  • Organizer: 4th International Drug Abuse Research Society Meeting
  • Place of Presentation: Mexico City, Mexico
• [Presentation] Development of the UCSD Performance-based Skills Assessment-Brief (UPSA-B) Japanese version (2013)
  • Author(s): Sumiyoshi C, Okahisa Y, Takaki M, Patterson T. L, Harvey P. D, Sumiyoshi T
  • Organizer: International Congress Cognition Satellite Meeting 2013
  • Place of Presentation: Orlando, Florida, USA
• [Presentation] Association study between the EAAT2 gene polymorphism and methamphetamine psychosis (2013)
  • Author(s): Sakamoto S, Okahisa Y, Mizuki Y, Takaki M, Kodama M, JGIDA, Ujike H, Uchitomi Y
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] The functional analysis of the human rho guanine nucleotide exchange factor 11 which is a risk for the paranoid subtype of schizophrenia (2013)
  • Author(s): Mizuki Y, Takaki M, Sakamoto S, Okahisa Y, Kodama M, Ujike H, Uchitomi Y
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] Pharmacogenomic study for Lamotorigine-induced cutaneous adverse drug reactions (2013)
  • Author(s): Saito T, Ikeda M, Kondo N, Okahisa Y, Hashimoto A, Ohnuma T, Hirose Y, Hashimoto R, Ozaki N, Iwata N
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto
• [Presentation] Development of the UCSD Performance-based Skills Assessment-Brief (UPSA-B) Japanese version: standardization and cross-national issues (2013)
  • Author(s): Sumiyoshi C, Okahisa Y, Takaki M, Nishiyama S, Mizukami Y, Patterson T, Harvey P, Sumiyoshi T
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto