A NIRS study to elucidate the relationship of splicing factor SRp20 and brain pathology in mood disorder patients

Research Project

Project/Area Number	25861012
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Psychiatric science
Research Institution	Yamaguchi University
Principal Investigator	WATANUKI Toshio 山口大学, 医学部附属病院, 助教 (80610865)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000) Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords	気分障害 / SRp20 / NIRS / うつ病 / 適応障害
Outline of Final Research Achievements	There was no significant difference among the four groups of adjustment disorder (AjD), major depressive disorder (MDD), bipolar disorder (BD) and healthy control subjects (HC) for SRp20mRNA expression levels in peripheral blood. For the average of [oxy-Hb] change during the VFT in the NIRS, poor significantly activated channels in both the temporal regions were observed in the MDD group than in the HC group. Also, poor significantly activated channels around the left temporal region were observed in AjD group than in the HC group. These results suggest that the NIRS is an important means for differenciating MDD and AjD.

Report

(4 results)