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A NIRS study to elucidate the relationship of splicing factor SRp20 and brain pathology in mood disorder patients

Research Project

Project/Area Number 25861012
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionYamaguchi University

Principal Investigator

WATANUKI Toshio  山口大学, 医学部附属病院, 助教 (80610865)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords気分障害 / SRp20 / NIRS / うつ病 / 適応障害
Outline of Final Research Achievements

There was no significant difference among the four groups of adjustment disorder (AjD), major depressive disorder (MDD), bipolar disorder (BD) and healthy control subjects (HC) for SRp20mRNA expression levels in peripheral blood. For the average of [oxy-Hb] change during the VFT in the NIRS, poor significantly activated channels in both the temporal regions were observed in the MDD group than in the HC group. Also, poor significantly activated channels around the left temporal region were observed in AjD group than in the HC group. These results suggest that the NIRS is an important means for differenciating MDD and AjD.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results)

  • [Presentation] 抑うつ状態におけるSRp20と脳機能との関連の検討2015

    • Author(s)
      綿貫俊夫, 松尾幸治, 原田健一郎, 中島麻美, 平田圭子, 樋口尚子, 樋口文宏, 柴田朋彦, 芳原輝之, 中野雅之, 大朏孝治, 松原敏郎, 山形弘隆, 渡邉義文
    • Organizer
      第34回躁うつ病の薬理生化学研究懇話会
    • Place of Presentation
      夢海游(兵庫県洲本市)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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