| Project/Area Number |
25861013
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ITO Hiromichi 徳島大学, 大学病院, 特任助教 (10398018)
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| Research Collaborator |
IMOTO Issei
MORI Kenji
TODA Yoshihiro
KAGAMI Shoji
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 自閉症スペクトラム障害 / イメージング / MRI / 1H-MRS / ゲノム解析 |
|---|
| Outline of Final Research Achievements |
① Proton magnetic resonance spectroscopy (1H-MRS) findings in autism spectrum disorder (ASD): We used 1H-MRS to investigate metabolite concentration ratios (adjusted by creatine/phosphocreatine (Cr)) in the anterior cingulate cortex (ACC) and left cerebellum in no less than 100 ASD. The control group included non-autistic below-normal intelligence quotient (IQ) and typically developed children. Typically developed children were investigated by brain MRI and 1H-MRS due to mild headache and no abnormalities were found. In the ASD group, Gamma-aminobutyric acid (GABA)＋/Cr was decreased in the ACC, and glutamate (Glu)/Cr was increased and GABA＋/Cr was decreased in the left cerebellum compared to those in the control. ② Genetic analysis in ASD: Approximately 30 subjects in ASD were analyzed. Target re-sequence in known ASD associated genes revealed no redundant mutations. It was difficult to classify pathophysiology in ASD by the genetic polymorphism or variation.
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