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Correlation between neuropsychiatric symptoms, FDG-PET, and serum BDNF in Alzheimer's disease

Research Project

Project/Area Number 25861015
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionEhime University

Principal Investigator

MORI Takaaki  愛媛大学, 医学部附属病院, 講師 (50444766)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsアルツハイマー病 / 脳由来神経栄養因子 / ポジトロン断層撮影 / ポジトロン断層法 / 精神行動障害 / FDG-PET
Outline of Final Research Achievements

We performed FDG-PET and evaluated serum brain-derived neurotrophic factor (BDNF) levels in 23 normal controls and 19 Alzheimer’s disease (AD) patients, and analyzed the correlation between cerebral metabolic rate of glucose on FDG-PET and serum BDNF levels. There was the significant negative correlation between left caudate nucleus and serum BDNF levels in AD, but there was no significant correlation in normal controls. Furthermore we analyzed the correlation between neuropsychiatric symptoms and serum BDNF levels, there was no finding. It is reported the association with left caudate nucleus and episodic memory in AD, it is assumed that BDNF is relevant to degeneration process in AD.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Relationship between regional cerebral blood flow and neuropsychiatric symptoms in dementia with Lewy bodies.2015

    • Author(s)
      Yoshida T, Mori T, Yamazaki K, Sonobe N, Shimizu H, Matsumoto T, Kikuchi K, Miyagawa M, Mochizuki T, Ueno SI.
    • Journal Title

      Int J Geriatr Psychiatry

      Volume: 17 Issue: 10 Pages: 1068-1075

    • DOI

      10.1002/gps.4263

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apathy correlates with prefrontal amyloid β deposition in Alzheimer's disease.2014

    • Author(s)
      Mori T, Shimada H, Shinotoh H, Hirano S, Eguchi Y, Yamada M, Fukuhara R, Tanimukai S, Zhang MR, Kuwabara S, Ueno S, Suhara T
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 85 Issue: 4 Pages: 449-455

    • DOI

      10.1136/jnnp-2013-306110

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] アルツハイマー病におけるAPP遺伝子プロモーター領域のDNAメチル化解析2014

    • Author(s)
      森 蓉子,越智 紳一郎,吉野 祐太,安部 賢郎,山崎 聖弘,吉田 卓,森 崇明,上野 修一
    • Organizer
      日本生物学的精神医学会
    • Place of Presentation
      奈良県文化会館(奈良)
    • Year and Date
      2014-09-29 – 2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 失名辞と緩徐に進行する近時記憶障害を呈した側頭葉前方部萎縮例2014

    • Author(s)
      小森憲治郎、豊田泰孝、吉田 卓、森 崇明、谷向 知
    • Organizer
      日本神経心理学会
    • Place of Presentation
      山形テルサ(山形)
    • Year and Date
      2014-09-26 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] アルツハイマー病におけるレーヴン色彩マトリックス検査と局所脳血流の関係2014

    • Author(s)
      吉田 卓,森 崇明,山崎聖広,園部直美,清水秀明,松本光央,小森憲治郎,谷向 知,上野修一
    • Organizer
      日本老年精神医学会
    • Place of Presentation
      日本教育会館(東京)
    • Year and Date
      2014-06-12 – 2014-06-13
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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