Pulse near-infrared light irradiation study in the depression

• Project/Area Number: 25861021
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Oita University
• Principal Investigator: TANAKA YOSHIHIRO 大分大学, 医学部, 助教 (60516102)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: うつ病 / 近赤外線光 / うつ病動物モデルラット / 効果十字迷路試験 / 明暗箱試験 / 恐怖条件付け試験 / 高架十字迷路試験

Outline of Final Research Achievements

As for the cure for depression, medical therapy and psychotherapy are important. Depression patients increased and considered treatment by near-infrared light as a cure in the future depression. I performed near-infrared light irradiation to a head and, using uneasiness and a depression animal model rat, confirmed presence of the antianxiety antidepressant action. I divided a rat into two groups and irradiated 5-minute near-infrared light consecutively in the irradiation group on a day for two weeks. I performed an elevated cross maze examination, a light camera examination, a fear conditioning examination to each rat and examined the difference of the antianxiety effect between control group and the irradiation group afterwards.The subacute pulse near-infrared light radiation significantly inhibited anxiety and depression in anxiolytic and depressive animal model rat. In addition, this significantly increased the neurogenesis in the rat hippocampus.

Research Products

• [Journal Article] Gender Determines Cortisol and Alpha-Amylase Responses to Acute Physical and Psychosocial Stress in Patients with Borderline Personality Disorder (2015)
  • Author(s): Ayako Inoue, Harumi Oshita, Yoshihiro Maruyama, Yoshihiro Tanaka, Yoshinobu Ishitobi, Aimi Kawano, Rie Ikeda, Tomoko Ando, Saeko Aizawa, Koji Masuda, Haruka Higuma, Masayuki Kanehisa, Taiga Ninomiya, Shunsuke Kobayashi, Jotaro Akiyoshi
  • Journal Title: Psychiatry Research Volume: in press Issue: 1 Pages: 46-52
  • DOI: 10.1016/j.psychres.2015.04.008
• [Journal Article] Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress (2014)
  • Author(s): Ｔsuru J, Tanaka Y, Ishitobi Y, Maruyama Y, Inoue A, Kawano A, Ikeda R, Ando T, Oshita H, Aizawa S, Masuda K, Higuma H, Kanehisa M, Ninomiya T, Akiyoshi J.
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: 10 Pages: 2123-2133
  • DOI: 10.2147/ndt.s68629
• [Journal Article] Clozapine responders may have fewer extrapyramidal symptoms than non-responders: a preliminary report. (2013)
  • Author(s): Shinjo Toyooka, Takeshi Terao, Nobuyoshi Ishii, Yoshihiro Tanaka, Kasuhiko Morinaga, Nobuhiko Hoaki, Yoshinobu Ishitobi, Haruka Higuma.
  • Journal Title: Clinical Neuropsychopharmacology and Therapeutics. Volume: CNPT4 Pages: 6-12
  • NAID: 130003373867
  • Peer Reviewed
• [Journal Article] The value of ethyl cysteinate dimer single photon emission computed tomography in predicting antidepressant treatment response in patients with major depression. (2013)
  • Author(s): Hanada H, Imanaga J, Yoshiiwa A, Yoshikawa T, Tanaka Y, Tsuru J, Inoue A, Ishitobi Y, Okamoto S, Kanehisa M, Maruyama Y, Ninomiya T, Higuma H, Isogawa K, Kawasaki T, Fujioka T, Akiyoshi J.
  • Journal Title: Int J Geriatr Psychiatry. Volume: 28 Issue: 7 Pages: 756-765
  • DOI: 10.1002/gps.3887
  • Peer Reviewed
• [Journal Article] The thyrotropin-releasing hormone test may predict recurrence of clinical depression within ten years after discharge. (2013)
  • Author(s): Tsuru J, Ishitobi Y, Ninomiya T, Kanehisa M, Imanaga J, Inoue A, Okamoto S, Maruyama Y, Higuma H, Tanaka Y, Hanada H, Isogawa K, Akiyoshi J.
  • Journal Title: Tsuru J, Ishitobi Y, Ninomiya T, Kanehisa M, Imanaga J, Inoue A, Okamoto S, Maruyama Y, Higuma H, Tanaka Y, Hanada H, Isogawa K, Akiyoshi J. Volume: 34 Pages: 409-417
  • Peer Reviewed
• [Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in patients with the generalized type of social anxiety disorder. (2013)
  • Author(s): Tamura A, Maruyama Y, Ishitobi Y, Kawano A, Ando T, Ikeda R, Inoue A, Imanaga J, Okamoto S, Kanehisa M, Ninomiya T, Tanaka Y, Tsuru J, Akiyoshi J.
  • Journal Title: Pharmacopsychiatry. Volume: 46 Issue: 07 Pages: 225-260
  • DOI: 10.1055/s-0033-1353157
  • Peer Reviewed
• [Journal Article] Ishitobi Y, Nakayama S, Kanehisa M, Higuma H, Maruyama Y, Okamoto S, Inoue A, Imanaga J, Tanaka Y, Tsuru J, Hanada H, Akiyoshi J. (2013)
  • Author(s): Association between corticotropin-releasing hormone receptor 1 and 2 (CRHR1 and CRHR2) gene polymorphisms and personality traits.
  • Journal Title: Psychiatr Genet. Volume: 23 Issue: 6 Pages: 255-257
  • DOI: 10.1097/ypg.0000000000000002
  • Peer Reviewed
• [Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrically stimulated physical stress in bipolar disorder patients. (2013)
  • Author(s): Tanaka Y, Maruyama Y, Ishitobi Y, Kawano A, Ando T, Ikeda R, Inoue A, Imanaga J, Okamoto S, Kanehisa M, Ninomiya T, Tsuru J, Akiyoshi J.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 8 Pages: 1899-1905
  • DOI: 10.2147/ndt.s48722
  • Peer Reviewed
• [Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in obsessive-compulsive disorder patients. (2012)
  • Author(s): Aimi Kawano, Yoshihiro Tanaka,Jotaro Akiyoshi. et al
  • Journal Title: Psychiatry Research Volume: article in press Issue: 1 Pages: 85-90
  • DOI: 10.1016/j.psychres.2012.11.010
  • Peer Reviewed
• [Presentation] 脳神経成長関連遺伝子ＮＴＲＫ２、ＢＤＮＦと脳容積・不安との関連研究 (2014)
  • Author(s): 藍澤早恵子、穐吉條太郎、増田幸司、石飛佳宣、井上綾子、兼久雅之、日隈晴香、二宮大雅、丸山義博、今永淳子、田中悦弘、河野義久
  • Organizer: the 110th Annual Meeting of the Japanese Society of Psychiatry and Neurology
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-06-26 – 2014-06-28
• [Presentation] 境界性パーソナリティー障害における自動思考とストレス誘発による唾液アミラーゼ・コルチゾール反応 (2014)
  • Author(s): 井上綾子、穐吉條太郎、田中悦弘、石飛佳宣、藍澤早恵子、増田幸司、安東友子、河野愛生、池田梨恵、今永淳子
  • Organizer: the 110th Annual Meeting of the Japanese Society of Psychiatry and Neurology
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-06-26 – 2014-06-28
• [Presentation] ソーシャルサポートと気分障害の重症度との関連研究 (2014)
  • Author(s): 増田幸司、藍澤早恵子、井上綾子、今永淳子、兼久雅之、二宮大雅、丸山義博、日隈晴香、石飛佳宣、田中悦弘、津留壽船、穐吉條太郎
  • Organizer: the 110th Annual Meeting of the Japanese Society of Psychiatry and Neurology
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-06-26 – 2014-06-28
• [Presentation] 回避性パーソナリティー障害における自動思考とストレス誘発による唾液アミラーゼ・コルチゾール反応 (2014)
  • Author(s): 石飛佳宣、井上綾子、田中悦弘、藍澤早恵子、増田幸司、安東友子、河野愛生、池田梨恵、今永淳子、丸山義博、日隈晴香、二宮大雅、穐吉條太郎
  • Organizer: the 110th Annual Meeting of the Japanese Society of Psychiatry and Neurology
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-06-26 – 2014-06-28
• [Presentation] BDNF Val66Met polymorphism is associated with different HPA and SAS axis reactivity to psychological and physical stress characterized by genotype interaction. (2013)
  • Author(s): Akiyoshi J, Tsuru J, Tanaka Y, Ishitobi Y, Maruyama Y, Kawano A, Ando T, Inoue A, Imanaga J, Okamoto S, Kanehisa M.
  • Organizer: 11th World Congress of Biological Psychiatry.
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] The catechol-O-methultransferase gene (COMT), other gene polymorphism and congnitive function. (2013)
  • Author(s): Ishitobi Y, Tanaka Y, Maruyama Y, Kawano A, Ando T, Inoue A, Okamoto S, Imanaga J, Kanehisa M, Higuma H, Ninomiya T, Tsuru J, Akiyoshi J.
  • Organizer: 11th World Congress of Biological Psychiatry.
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] BDNF Val66Met polymorphism is associated with different HPA and SAS axis reactivity to psychological and physical stress characterized by genotype interaction. (2013)
  • Author(s): Akiyoshi J, Tsuru J, Tanaka Y, Ishitobi Y, Maruyama Y, Inoue A, Kawano A, Ando T, Imanaga J, Okamoto S, Kanehisa M.
  • Organizer: 21st World Congress of Psychiatric Genetics.
  • Place of Presentation: Seaport Hotel&World Trade Center(アメリカ,ボストン)
• [Presentation] Association between transcription of neuroplasticity-related genes and variation in stress coping-style. (2013)
  • Author(s): Aizawa S, Ishitobi Y, Ando T, Kawano A, Ikeda R, Inoue A, Kanehisa M, Higuma H, Ninomiya T, Maruyama Y, Okamoto S, Imanaga J, Tsuru J, Tanaka Y, Akiyoshi J.
  • Organizer: 21st World Congress of Psychiatric Genetics.
  • Place of Presentation: Seaport Hotel&World Trade Center(アメリカ,ボストン)
• [Presentation] 大うつ病性障害・パニック障害での光トポグラフィーと唾液アミラーゼ反応. (2013)
  • Author(s): 山谷いずみ, 丸山義博, 石飛佳宣, 田中悦弘, 河野愛生, 安東友子, 大下晴美, 池田梨恵, 岡本静子, 井上綾子, 今永淳子, 兼久雅之, 日隈晴香, 二宮大雅, 津留壽船, 穐吉條太郎.
  • Organizer: 第109回日本精神神経学会学術総会
  • Place of Presentation: 福岡国際会議場、福岡サンパレスホテル＆ホール(福岡)
• [Presentation] 不安・うつ関連遺伝子多型とfMRIにおける顔表情認識の関連研究. (2013)
  • Author(s): 桐田光弘, 丸山義博, 石飛佳宣, 田中悦弘, 河野愛生, 安東友子, 池田梨恵, 岡本静子, 井上綾子, 今永淳子, 兼久雅之, 日隈晴香, 二宮大雅, 津留壽船, 穐吉條太郎.
  • Organizer: 第109回日本精神神経学会学術総会
  • Place of Presentation: 福岡国際会議場、福岡サンパレスホテル＆ホール(福岡)
• [Presentation] ストレスにおける唾液アミラーゼ・コルチゾール反応とTMEM212遺伝子研究. (2013)
  • Author(s): 井上綾子, 丸山義博, 石飛佳宣, 田中悦弘, 河野愛生, 安東友子, 池田梨恵, 岡本静子,今永淳子, 兼久雅之, 日隈晴香, 津留壽船, 花田浩昭, 穐吉條太郎
  • Organizer: 第109回日本精神神経学会学術総会
  • Place of Presentation: 福岡国際会議場、福岡サンパレスホテル＆ホール(福岡)
• [Presentation] パニック障害における感覚運動統合の機能不全とストレスの関連研究. (2013)
  • Author(s): 藍澤早恵子, 今永淳子, 井上綾子, 石飛佳宣, 田中悦弘, 河野愛生, 安東友子, 兼久雅之, 日隈晴香, 丸山義博, 二宮大雅, 岡本静子, 津留壽船, 穐吉條太郎.
  • Organizer: 第109回日本精神神経学会学術総会
  • Place of Presentation: 福岡国際会議場、福岡サンパレスホテル＆ホール(福岡)
• [Presentation] ストレスにおける唾液アミラーゼとFKBP5遺伝子多型との関連研究. (2013)
  • Author(s): 丸山義博, 石飛佳宣, 田中悦弘, 河野愛生, 安東友子, 池田梨恵, 岡本静子, 今永淳子, 井上綾子, 兼久雅之, 日隈晴香, 二宮大雅, 津留壽船, 花田浩昭, 穐吉條太郎.
  • Organizer: 第109回日本精神神経学会学術総会
  • Place of Presentation: 福岡国際会議場、福岡サンパレスホテル＆ホール(福岡)
• [Presentation] ソーシャルサポートとうつ病の重症度との関連研究. (2013)
  • Author(s): 増田幸司, 河野愛生, 安東友子, 池田梨恵, 藍澤早恵子, 井上綾子, 今永淳子, 兼久雅之, 二宮大雅, 丸山義博, 日隈晴香, 岡本静子, 石飛佳宣, 田中悦弘, 津留壽船, 穐吉條太郎.
  • Organizer: 第66回九州精神神経学会
  • Place of Presentation: かごしま県民交流センター(鹿児島)
• [Presentation] 天然活性水素水、人工水素水、蒸留水と抑うつ・不安・行動・代謝の関連研究. (2013)
  • Author(s): 兼久雅之, 石飛佳宣, 田中悦弘, 二宮大雅, 小林俊輔, 津留壽船, 穐吉條太郎.
  • Organizer: 第66回九州精神神経学会
  • Place of Presentation: かごしま県民交流センター(鹿児島)
• [Presentation] ストレス・うつ病に対する日田天領水の効果研究. (2013)
  • Author(s): 穐吉條太郎, 兼久雅之, 石飛佳宣, 田中悦弘, 二宮大雅, 小林俊輔, 津留壽船.
  • Organizer: 第43回日本創傷治癒学会.
  • Place of Presentation: 別府湾ロイヤルホテル(大分)