Pulse near-infrared light irradiation study in the depression
Project/Area Number |
25861021
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
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Research Institution | Oita University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | うつ病 / 近赤外線光 / うつ病動物モデルラット / 効果十字迷路試験 / 明暗箱試験 / 恐怖条件付け試験 / 高架十字迷路試験 |
Outline of Final Research Achievements |
As for the cure for depression, medical therapy and psychotherapy are important. Depression patients increased and considered treatment by near-infrared light as a cure in the future depression. I performed near-infrared light irradiation to a head and, using uneasiness and a depression animal model rat, confirmed presence of the antianxiety antidepressant action. I divided a rat into two groups and irradiated 5-minute near-infrared light consecutively in the irradiation group on a day for two weeks. I performed an elevated cross maze examination, a light camera examination, a fear conditioning examination to each rat and examined the difference of the antianxiety effect between control group and the irradiation group afterwards.The subacute pulse near-infrared light radiation significantly inhibited anxiety and depression in anxiolytic and depressive animal model rat. In addition, this significantly increased the neurogenesis in the rat hippocampus.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Gender Determines Cortisol and Alpha-Amylase Responses to Acute Physical and Psychosocial Stress in Patients with Borderline Personality Disorder2015
Author(s)
Ayako Inoue, Harumi Oshita, Yoshihiro Maruyama, Yoshihiro Tanaka, Yoshinobu Ishitobi, Aimi Kawano, Rie Ikeda, Tomoko Ando, Saeko Aizawa, Koji Masuda, Haruka Higuma, Masayuki Kanehisa, Taiga Ninomiya, Shunsuke Kobayashi, Jotaro Akiyoshi
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Journal Title
Psychiatry Research
Volume: in press
Issue: 1
Pages: 46-52
DOI
Related Report
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[Journal Article] Association of BDNF Val66Met polymorphism with HPA and SAM axis reactivity to psychological and physical stress2014
Author(s)
Tsuru J, Tanaka Y, Ishitobi Y, Maruyama Y, Inoue A, Kawano A, Ikeda R, Ando T, Oshita H, Aizawa S, Masuda K, Higuma H, Kanehisa M, Ninomiya T, Akiyoshi J.
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Journal Title
Neuropsychiatric Disease and Treatment
Volume: 10
Pages: 2123-2133
DOI
Related Report
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[Journal Article] The value of ethyl cysteinate dimer single photon emission computed tomography in predicting antidepressant treatment response in patients with major depression.2013
Author(s)
Hanada H, Imanaga J, Yoshiiwa A, Yoshikawa T, Tanaka Y, Tsuru J, Inoue A, Ishitobi Y, Okamoto S, Kanehisa M, Maruyama Y, Ninomiya T, Higuma H, Isogawa K, Kawasaki T, Fujioka T, Akiyoshi J.
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Journal Title
Int J Geriatr Psychiatry.
Volume: 28
Issue: 7
Pages: 756-765
DOI
Related Report
Peer Reviewed
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[Journal Article] The thyrotropin-releasing hormone test may predict recurrence of clinical depression within ten years after discharge.2013
Author(s)
Tsuru J, Ishitobi Y, Ninomiya T, Kanehisa M, Imanaga J, Inoue A, Okamoto S, Maruyama Y, Higuma H, Tanaka Y, Hanada H, Isogawa K, Akiyoshi J.
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Journal Title
Tsuru J, Ishitobi Y, Ninomiya T, Kanehisa M, Imanaga J, Inoue A, Okamoto S, Maruyama Y, Higuma H, Tanaka Y, Hanada H, Isogawa K, Akiyoshi J.
Volume: 34
Pages: 409-417
Related Report
Peer Reviewed
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[Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrical stimulation stress in patients with the generalized type of social anxiety disorder.2013
Author(s)
Tamura A, Maruyama Y, Ishitobi Y, Kawano A, Ando T, Ikeda R, Inoue A, Imanaga J, Okamoto S, Kanehisa M, Ninomiya T, Tanaka Y, Tsuru J, Akiyoshi J.
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Journal Title
Pharmacopsychiatry.
Volume: 46
Issue: 07
Pages: 225-260
DOI
Related Report
Peer Reviewed
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[Journal Article] Ishitobi Y, Nakayama S, Kanehisa M, Higuma H, Maruyama Y, Okamoto S, Inoue A, Imanaga J, Tanaka Y, Tsuru J, Hanada H, Akiyoshi J.2013
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[Journal Article] Salivary alpha-amylase and cortisol responsiveness following electrically stimulated physical stress in bipolar disorder patients.2013
Author(s)
Tanaka Y, Maruyama Y, Ishitobi Y, Kawano A, Ando T, Ikeda R, Inoue A, Imanaga J, Okamoto S, Kanehisa M, Ninomiya T, Tsuru J, Akiyoshi J.
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Journal Title
Neuropsychiatr Dis Treat
Volume: 8
Pages: 1899-1905
DOI
Related Report
Peer Reviewed
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[Presentation] BDNF Val66Met polymorphism is associated with different HPA and SAS axis reactivity to psychological and physical stress characterized by genotype interaction.2013
Author(s)
Akiyoshi J, Tsuru J, Tanaka Y, Ishitobi Y, Maruyama Y, Kawano A, Ando T, Inoue A, Imanaga J, Okamoto S, Kanehisa M.
Organizer
11th World Congress of Biological Psychiatry.
Place of Presentation
国立京都国際会館(京都)
Related Report
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[Presentation] The catechol-O-methultransferase gene (COMT), other gene polymorphism and congnitive function.2013
Author(s)
Ishitobi Y, Tanaka Y, Maruyama Y, Kawano A, Ando T, Inoue A, Okamoto S, Imanaga J, Kanehisa M, Higuma H, Ninomiya T, Tsuru J, Akiyoshi J.
Organizer
11th World Congress of Biological Psychiatry.
Place of Presentation
国立京都国際会館(京都)
Related Report
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[Presentation] BDNF Val66Met polymorphism is associated with different HPA and SAS axis reactivity to psychological and physical stress characterized by genotype interaction.2013
Author(s)
Akiyoshi J, Tsuru J, Tanaka Y, Ishitobi Y, Maruyama Y, Inoue A, Kawano A, Ando T, Imanaga J, Okamoto S, Kanehisa M.
Organizer
21st World Congress of Psychiatric Genetics.
Place of Presentation
Seaport Hotel&World Trade Center(アメリカ,ボストン)
Related Report
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[Presentation] Association between transcription of neuroplasticity-related genes and variation in stress coping-style.2013
Author(s)
Aizawa S, Ishitobi Y, Ando T, Kawano A, Ikeda R, Inoue A, Kanehisa M, Higuma H, Ninomiya T, Maruyama Y, Okamoto S, Imanaga J, Tsuru J, Tanaka Y, Akiyoshi J.
Organizer
21st World Congress of Psychiatric Genetics.
Place of Presentation
Seaport Hotel&World Trade Center(アメリカ,ボストン)
Related Report
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[Presentation] 大うつ病性障害・パニック障害での光トポグラフィーと唾液アミラーゼ反応.2013
Author(s)
山谷いずみ, 丸山義博, 石飛佳宣, 田中悦弘, 河野愛生, 安東友子, 大下晴美, 池田梨恵, 岡本静子, 井上綾子, 今永淳子, 兼久雅之, 日隈晴香, 二宮大雅, 津留壽船, 穐吉條太郎.
Organizer
第109回日本精神神経学会学術総会
Place of Presentation
福岡国際会議場、福岡サンパレスホテル&ホール(福岡)
Related Report
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[Presentation] 不安・うつ関連遺伝子多型とfMRIにおける顔表情認識の関連研究.2013
Author(s)
桐田光弘, 丸山義博, 石飛佳宣, 田中悦弘, 河野愛生, 安東友子, 池田梨恵, 岡本静子, 井上綾子, 今永淳子, 兼久雅之, 日隈晴香, 二宮大雅, 津留壽船, 穐吉條太郎.
Organizer
第109回日本精神神経学会学術総会
Place of Presentation
福岡国際会議場、福岡サンパレスホテル&ホール(福岡)
Related Report
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[Presentation] ストレスにおける唾液アミラーゼ・コルチゾール反応とTMEM212遺伝子研究.2013
Author(s)
井上綾子, 丸山義博, 石飛佳宣, 田中悦弘, 河野愛生, 安東友子, 池田梨恵, 岡本静子,今永淳子, 兼久雅之, 日隈晴香, 津留壽船, 花田浩昭, 穐吉條太郎
Organizer
第109回日本精神神経学会学術総会
Place of Presentation
福岡国際会議場、福岡サンパレスホテル&ホール(福岡)
Related Report
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[Presentation] パニック障害における感覚運動統合の機能不全とストレスの関連研究.2013
Author(s)
藍澤早恵子, 今永淳子, 井上綾子, 石飛佳宣, 田中悦弘, 河野愛生, 安東友子, 兼久雅之, 日隈晴香, 丸山義博, 二宮大雅, 岡本静子, 津留壽船, 穐吉條太郎.
Organizer
第109回日本精神神経学会学術総会
Place of Presentation
福岡国際会議場、福岡サンパレスホテル&ホール(福岡)
Related Report
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[Presentation] ストレスにおける唾液アミラーゼとFKBP5遺伝子多型との関連研究.2013
Author(s)
丸山義博, 石飛佳宣, 田中悦弘, 河野愛生, 安東友子, 池田梨恵, 岡本静子, 今永淳子, 井上綾子, 兼久雅之, 日隈晴香, 二宮大雅, 津留壽船, 花田浩昭, 穐吉條太郎.
Organizer
第109回日本精神神経学会学術総会
Place of Presentation
福岡国際会議場、福岡サンパレスホテル&ホール(福岡)
Related Report
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[Presentation] ソーシャルサポートとうつ病の重症度との関連研究.2013
Author(s)
増田幸司, 河野愛生, 安東友子, 池田梨恵, 藍澤早恵子, 井上綾子, 今永淳子, 兼久雅之, 二宮大雅, 丸山義博, 日隈晴香, 岡本静子, 石飛佳宣, 田中悦弘, 津留壽船, 穐吉條太郎.
Organizer
第66回九州精神神経学会
Place of Presentation
かごしま県民交流センター(鹿児島)
Related Report
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