| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Functional neuroimaging studies have suggested that individuals with an at-risk mental state (ARMS) have frontal lobe dysfunction. We examined whether adolescents with ARMS have reduced prefrontal hemodynamic response as measured by near-infrared spectroscopy. Ten treatment-naive subjects, aged 12-20 years and diagnosed with ARMS according to the Criteria of Psychosis-Risk Syndromes, were compared with 10 age- and IQ-matched healthy controls. The subjects with ARMS were evaluated with the Structured Interview for Prodromal Syndrome/Scale of Prodromal Symptoms. Written informed consent was obtained from all participants and/or their parents prior to the study. The relative concentrations of oxyhemoglobin were measured during the Stroop color-word task. The oxyhemoglobin changes in the ARMS group were significantly smaller than those in the control group at prefrontal cortex. The present study suggests that the adolescents with ARMS had reduced prefrontal hemodynamic response.
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