fficacy and tolerability of escitalopram versus paroxetine-CR in Japanese patients with major depressive disorder: a randomized, masked-rater trial

• Project/Area Number: 25861033
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Fujita Health University
• Principal Investigator: KISHI Taro 藤田保健衛生大学, 医学部, 講師 (40536801)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 大うつ病性障害 / エスシタロプラム / パロキセチン徐放製剤 / 効果 / 安全性 / 大うつ病性障害と / 無作為割付試験

Outline of Final Research Achievements

We included about one hundred patients with major depressive disorder. Some patients who enter the study have not complete the study. Regarding the interim analysis (not all patients include), there were not significant differences in the outcomes with respect to efficacy and safety between both treatment groups.

Research Products

• [Journal Article] Aripiprazole for the management of schizophrenia in the Japanese population: a systematic review and meta-analysis of randomized controlled trials. (2015)
  • Author(s): Kishi T, Matsuda Y, Matsunaga S, Iwata N.
  • Journal Title: Neuropsychiatr Dis Treat Volume: 20 Pages: 419-34
  • DOI: 10.2147/ndt.s78977
  • Peer Reviewed / Open Access
• [Journal Article] Cardiometabolic risks of blonanserin and perospirone in the management of schizophrenia: a systematic review and meta-analysis of randomized controlled trials. (2014)
  • Author(s): Kishi T, Matsuda Y, Iwata N.
  • Journal Title: PLoS One Volume: 4 Issue: 2 Pages: 1-2
  • DOI: 10.1371/journal.pone.0088049
  • Peer Reviewed / Open Access
• [Journal Article] Azapirone 5-HT1A receptor partial agonist treatment for major depressive disorder: systematic review and meta-analysis. (2014)
  • Author(s): Kishi T, Meltzer HY, Matsuda Y, Iwata N.
  • Journal Title: Psychol Med Volume: 44 Pages: 2255-69
  • Peer Reviewed / Open Access
• [Journal Article] Meta-analysis of noradrenergic and specific serotonergic antidepressant use in schizophrenia. (2014)
  • Author(s): Kishi T, Iwata N.
  • Journal Title: Int J Neuropsychopharmacol. Volume: 17 Issue: 02 Pages: 343-54
  • DOI: 10.1017/s1461145713000667
  • Peer Reviewed / Open Access
• [Journal Article] Selective serotonin 3 receptor antagonist treatment for schizophrenia: meta-analysis and systematic review. (2014)
  • Author(s): Kishi T, Mukai T, Matsuda Y, Iwata N.
  • Journal Title: Neuromolecular Med Volume: 16 Issue: 1 Pages: 61-9
  • DOI: 10.1007/s12017-013-8251-0
  • Peer Reviewed / Open Access
• [Journal Article] Antipsychotics for cocaine or psychostimulant dependence: systematic review and meta-analysis of randomized, placebo-controlled trials. (2013)
  • Author(s): Kishi T, Matsuda Y, Iwata N, Correll CU.
  • Journal Title: J Clin Psychiatry Volume: 74 Issue: 12 Pages: 1169-80
  • DOI: 10.4088/jcp.13r08525
  • Peer Reviewed
• [Journal Article] Azapirone 5-HT1A receptor partial agonist treatment for major depressive disorder: systematic review and meta-analysis. (2013)
  • Author(s): Kishi T, Meltzer HY, Matsuda Y, Iwata N.
  • Journal Title: Psychol Med. Volume: 21 Pages: 1-15
  • Peer Reviewed
• [Journal Article] Antipsychotics for primary alcohol dependence: a systematic review and meta-analysis of placebo-controlled trials. (2013)
  • Author(s): Kishi T, Sevy S, Chekuri R, Correll CU.
  • Journal Title: J Clin Psychiatry. Volume: 74 Issue: 07 Pages: 642-54
  • DOI: 10.4088/jcp.12r08178
• [Journal Article] Efficacy and safety of noradrenalin reuptake inhibitor augmentation therapy for schizophrenia: a meta-analysis of double-blind randomized placebo-controlled trials. (2013)
  • Author(s): Kishi T, Mukai T, Matsuda Y, Moriwaki M, Iwata N.
  • Journal Title: J Psychiatr Res Volume: 47 Issue: 11 Pages: 1557-63
  • DOI: 10.1016/j.jpsychires.2013.07.003
  • Peer Reviewed