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Research of microglial epigenetics as a mechanism of constructing stress vulnerability

Research Project

Project/Area Number 25861036
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionHiroshima University (2014)
Hiroshima International University (2013)

Principal Investigator

YAMAWAKI YOSUKE  広島大学, 医歯薬保健学研究院(歯), 助教 (90584061)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsうつ病 / ストレス脆弱性 / ミクログリア / エピジェネティクス / HDAC阻害薬 / 精神疾患 / 炎症 / グリア / 炎症性サイトカイン
Outline of Final Research Achievements

The object of this study is to elucidate a mechanism of stress vulnerability from a view of neuro-immune system. Treatment of lipopolysaccharide (5 mg/kg, i.p.) induced persisting microglial activation in hippocampus and elongated immobility time in forced swim test (FST). Repeated treatment with sodium butyrate (SB), HDAC inhibitor, inhibited the LPS-induced microglial activation and decreased the immobility time in FST. cDNA Microarray using isolated hippocampal microglia treated with LPS and/or SB revealed the several candidate genes, relating to regulating macrophage function, immune system and mechanism of antidepressant.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] The potential use of histone deacetylase inhibitors in the treatment of depression2015

    • Author(s)
      Fuchikami M, Morinobu S, et al.
    • Journal Title

      Progress in Neuro-Psychopharmacology & Biological Psychiatry

      Volume: 62 Pages: 00059-7

    • DOI

      10.1016/j.pnpbp.2015.03.010

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: An exploratory magnetic resonance imaging voxel-based morphometry study.2014

    • Author(s)
      Machino, A., Kunisato, Y., Matsumoto, T., Yoshimura, S., Ueda, K., Yamawaki, Y., ... & Yamawaki, S.
    • Journal Title

      Journal of Affective Disorders

      Volume: 168 Pages: 229-235

    • DOI

      10.1016/j.jad.2014.06.030

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] Sodium butyrate ameliorates inflammation-induced depression-like behavior via inhibition of microglial activation2015

    • Author(s)
      Yosuke Yamawaki, Norika Yoshioka, Misako Nishida, Ayaka Murai, Takashi Kanematsu, Hiroyuki Akagi
    • Organizer
      CINP2015
    • Place of Presentation
      ダブリン/英国
    • Year and Date
      2015-06-03 – 2015-06-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] ミクログリア抑制効果に基づくHDAC阻害薬の抗うつ効果の検討2015

    • Author(s)
      山脇洋輔、吉岡伯華、西田美沙子、村井彩佳、吉野貴成、赤木宏行
    • Organizer
      日本薬学会 第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 酪酸ナトリウムによる炎症誘発性うつ病様行動の改善効果2015

    • Author(s)
      山脇 洋輔, 吉岡 伯華, 西田 美沙子, 村井 彩佳, 大植 香菜, 林内 優樹, 兼松 隆, 赤木 宏行
    • Organizer
      第88回 日本薬理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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