| Project/Area Number |
25861036
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Hiroshima University (2014)
Hiroshima International University (2013) |
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Principal Investigator |
YAMAWAKI YOSUKE 広島大学, 医歯薬保健学研究院(歯), 助教 (90584061)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | うつ病 / ストレス脆弱性 / ミクログリア / エピジェネティクス / HDAC阻害薬 / 精神疾患 / 炎症 / グリア / 炎症性サイトカイン |
|---|
| Outline of Final Research Achievements |
The object of this study is to elucidate a mechanism of stress vulnerability from a view of neuro-immune system. Treatment of lipopolysaccharide (5 mg/kg, i.p.) induced persisting microglial activation in hippocampus and elongated immobility time in forced swim test (FST). Repeated treatment with sodium butyrate (SB), HDAC inhibitor, inhibited the LPS-induced microglial activation and decreased the immobility time in FST. cDNA Microarray using isolated hippocampal microglia treated with LPS and/or SB revealed the several candidate genes, relating to regulating macrophage function, immune system and mechanism of antidepressant.
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