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Analyses of increased pain tolerance during mouse Transport Response

Research Project

Project/Area Number 25861038
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionToho University (2014)
University of Tsukuba (2013)

Principal Investigator

YOSHIDA Sachine  東邦大学, 医学部, 助教 (90513458)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsマウス / 輸送反応 / トランスポートレスポンス / 鎮痛 / 愛着 / 親子関係 / 乳児
Outline of Final Research Achievements

A mother carries the young in many altricial mammals. Meanwhile, the transported young immediately assume a compact posture and stay calm. This young’s response to maternal transport is called “Transport Response (TR)”. TR is a coordinated set of central, motor, and cardiac regulations and is a conserved component of mammalian mother-infant interaction.
Preliminary experiments showed that another possible feature of TR was the behavioral insensitivity to pain. This study revealed that increased pain tolerance during TR was seen throughout the body and regulated by an opioid-independent mechanism. A previous study showed that rat pups displayed apparent analgesia during suckling via a non-opioidergic mechanism. Increased pain tolerance observed in mother-infant interaction may share some common neural mechanism(s).

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Invited: 1 results) Remarks (2 results)

  • [Journal Article] The calming effect of maternal carrying in different mammalian species2015

    • Author(s)
      Gianluca Esposito, Peipei Setoh, Sachine Yoshida, Kumi O. Kuroda
    • Journal Title

      Frontiers in Psychology

      Volume: 6 Pages: 445-445

    • DOI

      10.3389/fpsyg.2015.00445

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An inhalation anesthetic device for stereotaxic operation on mouse pups2015

    • Author(s)
      Sachine Yoshida1, 2, Yuya Morimoto, Taishi Tonooka, Shoji Takeuchi
    • Journal Title

      Journal of Neuroscience Methods

      Volume: 243 Pages: 63-67

    • DOI

      10.1016/j.jneumeth.2015.01.025

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Transport response is a filial specific behavioral response to maternal carrying in C57BL/6 mice2013

    • Author(s)
      Sachine Yoshida, Gianluca Espostio, Ryuko Ohnishi, Yosuke Tsuneoka, Shota Okabe, Takefumi Kikusui. Tadafumi Kato. Kumi
    • Journal Title

      Frontiers in Zoology

      Volume: 0 Issue: 1 Pages: 50-50

    • DOI

      10.1186/1742-9994-10-50

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Infant calming responses during maternal carrying in humans and mice2013

    • Author(s)
      Gianluca Esposito, Sachine Yoshida (equal contribution)
    • Journal Title

      Current Biology

      Volume: 23 Issue: 9 Pages: 1-7

    • DOI

      10.1016/j.cub.2013.03.041

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional, anatomical, and neurochemical differentiation of medial preoptic area subregions in relation to maternal behavior in the mouse2013

    • Author(s)
      Yousuke Tsuneoka
    • Journal Title

      Journal of Comparative Neurology

      Volume: 521 Issue: 7 Pages: 1633-1663

    • DOI

      10.1002/cne.23251

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Development of an inhalation anesthetic device for mouse pups equipped with brain stereotaxic function2014

    • Author(s)
      Sachine Yoshida, Yuya Morimoto, Taishi Tonooka, Shoji Takeuchi
    • Organizer
      The 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    • Place of Presentation
      サンアントニオ(アメリカ)
    • Year and Date
      2014-10-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抱いて歩くと乳児がおとなしくなる仕組み:乳児と仔マウスの輸送反応2014

    • Author(s)
      吉田さちね
    • Organizer
      ベビーウエアリング研究会 拡大セミナ-
    • Place of Presentation
      東京工業大学キャンパスイノベーションセンター(東京都・港区)
    • Year and Date
      2014-06-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 母親に運ばれる時に起こる子の鎮静化反応:ヒト乳児と仔マウスを用いた比較研究および生後発達解析2014

    • Author(s)
      吉田さちね、Gianluca Esposito、黒田公美
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学(鹿児島市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Early Mother-Infant Interaction: Comparative Physiological Assessment of Infant Calming Response in Human and Mouse2013

    • Author(s)
      Esposito G, Yoshida S,Kuroda KO
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego Convention Center, San Diego (USA)
    • Related Report
      2013 Research-status Report
  • [Remarks] 黒田親和性社会行動研究ユニット

    • URL

      http://asb.brain.riken.jp/index_j.html

    • Related Report
      2013 Research-status Report
  • [Remarks] 抱っこして歩くと赤ちゃんがリラックスする仕組みの一端を解明

    • URL

      http://www.riken.jp/pr/press/2013/20130419_2/

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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