A PET study of dopaminergic modification of conscious experiences

• Project/Area Number: 25861039
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: Takahata Keisuke 国立研究開発法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (20645311)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: ドーパミン / 主観的体験 / fMRI / PET / 自己意識 / 行動実験 / パイロット実験 / 心理課題の調整 / PET画像の予備解析 / 心理課題の選定 / 心理課題のプログラミング / 心理評価尺度の選定 / 他研究機関との討論 / 画像解析技術の習得

Outline of Final Research Achievements

To elucidate dopaminergic modification of conscious experiences, we conducted three experiences. First, using the modified intentional binding task, we revealed healthy subjects and depressive patients showed different patterns in emotional modulation of sense of agency. Our results showed that depressive patients showed diminished tendency of self-serving bias for negative outcomes compared healthy subjects. Second, we designed the behavioral task to evaluate subject’s feeling of empathy for the opponent who showed emotional reaction for the punishment. We found that empathy for the opponent is diminished when punishment was given by another subject. We are conducting fMRI study using this behavioral task. Third, we investigated association among dopamine D2 receptor density measured by [11C]FLB457 PET and capacity for divergent thinking. We revealed D2 receptor density in the right prefrontal cortex showed a negative correlation with divergent thinking capacity.

Research Products

• [Journal Article] [11C]TASP457, a novel PET ligand for histamine H3 receptors in human brain. Eur J Nucl Med Mol Imaging. (2016)
  • Author(s): Kimura Y, Seki C, Ikoma Y, Ichise M, Kawamura K, Takahata K, Moriguchi S, Nagashima T, Ishii T, Kitamura S, Niwa F, Endo H, Yamada M, Higuchi M, Zhang MR, Suhara T
  • Journal Title: Eur J Nucl Med Mol Imaging Volume: 1 Issue: 9 Pages: 1-11
  • DOI: 10.1007/s00259-016-3332-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Behavioral evidence of delayed prediction signals during agency attribution in patients with schizophrenia. (2015)
  • Author(s): Koreki, A., Maeda, T., Fukushima, H., Umeda, S., Takahata, K., Okimura, T., Funayama, M., Iwashita, S., Mimura, M., & Kato, M. (2015)
  • Journal Title: Psychiatry Research Volume: 230 Issue: 1 Pages: 78-83
  • DOI: 10.1016/j.psychres.2015.08.023
  • Peer Reviewed / Open Access
• [Journal Article] Discrepancy between explicit judgement of agency and implicit feeling of agency: Implications for sense of agency and its disorders. (2015)
  • Author(s): Saito N, Takahata K, Murai T, Takahashi H.
  • Journal Title: Conscious Cogn. Volume: 印刷中 Pages: 1-7
  • DOI: 10.1016/j.concog.2015.07.011
  • NAID: 120005674593
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 頭部外傷をめぐる最近の話題 頭部外傷の分子イメージング 慢性外傷性脳症(CTE)と頭部外傷後精神病(PDFTBI)を中心に(解説) (2015)
  • Author(s): 高畑 圭輔, 加藤 元一郎, 三村 將, 島田 斉, 樋口 真人, 須原 哲也
  • Journal Title: 高次脳機能研究 Volume: 35 Pages: 276-282
• [Journal Article] default-mode networkと認知障害：後部帯状回の機能と注意・記憶との関係について (2014)
  • Author(s): 高畑圭輔、加藤元一郎
  • Journal Title: 神経心理学 Volume: 30 Pages: 249-249
• [Journal Article] Enhanced visual artistry and high accuracy of visual numerosity representation after left prefrontal damage (2014)
  • Author(s): Keisuke Takahata, Fumie Saito, Taro Muramatsu, Makiko Yamada, Joichiro Shirahase, Hajime Tabuchi1, Tetsuya Suhara, Masaru Mimura, Motoichiro Kato
  • Journal Title: Neuropsychologia Volume: 57 Pages: 28-49
  • DOI: 10.1016/j.neuropsychologia.2014.02.022
  • Peer Reviewed
• [Journal Article] Reproducibility of PET measurement for presynaptic dopaminergic functions using L-[β-(11)C]DOPA and [(18)F]FE-PE2I in humans. (2014)
  • Author(s): Suzuki M, Ito H, Kodaka F, Takano H, Kimura Y, Fujiwara H, Sasaki T, Takahata K, Nogami T, Nagashima T, Nengaki N, Kawamura K, Zhang MR, Varrone A, Halldin C, Okubo Y, Suhara T.
  • Journal Title: Nucl Med Commun. Volume: 35 Issue: 3 Pages: 231-237
  • DOI: 10.1097/mnm.0000000000000052
  • Peer Reviewed
• [Journal Article] Reduced sense of agency in chronic residual schizophrenia with predominant negative symptoms. (2013)
  • Author(s): Takaki Maeda, Keisuke Takahata, Taro Muramatsu, Tsukasa Okimura, Akihiro Koreki,,Satoru Iwashita, Masaru Mimura, and Motoichiro Kato
  • Journal Title: Psychiatry Research Volume: 209(3) Issue: 3 Pages: 386-392
  • DOI: 10.1016/j.psychres.2013.04.017
  • Peer Reviewed
• [Journal Article] Superiority illusion arises from resting-state brain network modulated by dopamine. (2013)
  • Author(s): Yamada, M., Uddin, L. Q., Takahashi, H., Kimura, Y., Takahata, K., Kousa, R., Ikoma, Y., Eguchi, Y., Takano, H., Ito, H., Higuchi, M., & Suhara, T.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 110 Issue: 11 Pages: 4363-4367
  • DOI: 10.1073/pnas.1221681110
  • Peer Reviewed
• [Journal Article] 老年期の妄想：臨床概念の変遷と認知神経科学モデル (2013)
  • Author(s): 高畑 圭輔、三村 將
  • Journal Title: 神経心理学雑誌 Volume: 29 Pages: 243-256
• [Journal Article] 獲得性サヴァン症候群 (2013)
  • Author(s): 高畑 圭輔
  • Journal Title: Clinical Neuroscience Volume: 11 Pages: 1293-1295
• [Presentation] 神経現象学 (neurophenomenology) -意識(主観的体験)の科学と精神医学の接点- (2016)
  • Author(s): 高畑圭輔
  • Organizer: 群馬・脳とこころのアカデミー
  • Place of Presentation: 群馬県
  • Year and Date: 2016-02-20
• [Presentation] 頭部外傷による遅発性の症候と病態について (2015)
  • Author(s): 高畑圭輔
  • Organizer: 第３９回高次脳機能障害学会
  • Place of Presentation: 東京都
  • Year and Date: 2015-12-10
  • Invited
• [Presentation] Imaging of tau and amyloid pathology in patients with traumatic brain injury: A PET (2015)
  • Author(s): Keisuke Takahata, Hitoshi Shimada, Makoto Higuchi, Hitoshi Shinotoh, Yasuyuki Kimura1, Soichiro Kitamura1, Hironobu, Endo1, Fumitoshi Niwa1, Sho Moriguchi, Masanori Ichise, Naruhiko Sahara, Masaru Mimura, Motoichiro Kato, Jin Mizushima, Hajime Tabuchi, Makiko Yamada, Tetsuya Suhara
  • Organizer: Annual Meeting of Society of Biological Psychiatry
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] Association among extrastriatal dopamine D2 receptor binding, idea fluency and depersonalization: A positron emission tomography study (2014)
  • Author(s): Keisuke Takahata, Tetsuya Suhara, Makiko Yamada
  • Organizer: 30th International Congress of Clinical Neurophysiology (ICCN) of the IFCN
  • Place of Presentation: Berlin, Germany
• [Presentation] Affective Modulation of Agency and its role in self-serving bias and self-blaming bias: A preliminary result (2013)
  • Author(s): Keisuke Takahata, Motoichiro Kato, Hidehiko Takahashi2, Takaki Maeda, Akihiro Koreki, Sho Moriguchi, Testuya Suhara, Masaru Mimura
  • Organizer: 17th Annual meeting of ASSC
  • Place of Presentation: California, USA