Continuity between schizophrenia and mood disorders: a comprehensive investigation of genes, cognition and schizotypal traits

• Project/Area Number: 25861041
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: HORI Hiroaki 独立行政法人国立精神・神経医療研究センター, 精神保健研究所 成人精神保健研究部, 室長 (10554397)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 統合失調症 / 気分障害 / 統合失調型パーソナリティ / 認知機能 / 遺伝子多型 / 遺伝子 / パーソナリティ

Outline of Final Research Achievements

We examined continuity and discontinuity between schizophrenia and mood disorders by investigating candidate gene variants, comprehensive cognitive functioning and personality characteristics in patients with schizophrenia, those with mood disorders and healthy control subjects. We have conducted a set of studies and obtained results suggesting genetic similarities between the two disorders. These results are considered to advance findings from relevant studies and contribute to elucidating the pathogenesis of schizophrenia and mood disorders.

Research Products

• [Journal Article] Increased protein and mRNA expression of resistin after dexamethasone administration (2015)
  • Author(s): Sasayama D, Hori H, Nakamura S, Yamamoto N, Hattori K, Teraishi T, Ota M, Kunugi H
  • Journal Title: Hormone and Metabolic Research Volume: 47 Issue: 6 Pages: 433
  • DOI: 10.1055/s-0034-1383651
  • Peer Reviewed
• [Journal Article] Personality in remitted major depressive disorder with single and recurrent episodes assessed with the Temperament and Character Inventory (2015)
  • Author(s): Teraishi T, Hori H, Sasayama D, Matsuo J, Ogawa S, Ishida I, Nagashima A, Kinoshita Y, Ota M, Hattori K, Higuchi T, Kunugi H
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 69 Issue: 1 Pages: 3
  • DOI: 10.1111/pcn.12218
  • Peer Reviewed
• [Journal Article] White matter abnormalities in major depressive disorder with melancholic and atypical features: A diffusion tensor imaging study (2015)
  • Author(s): Ota M, Noda T, Sato N, Hattori K, Hori H, Sasayama D, Teraishi T, Nagashima A, Obu S, Higuchi T, Kunugi H
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 69 Issue: 6 Pages: 360
  • DOI: 10.1111/pcn.12255
  • Peer Reviewed / Open Access
• [Journal Article] Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder (2015)
  • Author(s): Ogawa S, Hattori K, Sasayama D, Yokota Y, Matsumura R, Matsuo J, Ota M, Hori H, Teraishi T, Yoshida S, Noda T, Ohashi Y, Sato H, Higuchi T, Motohashi N, Kunugi H
  • Journal Title: Sci Rep Volume: 5 Issue: 1 Pages: 7796-7796
  • DOI: 10.1038/srep07796
  • Peer Reviewed / Open Access
• [Journal Article] Characteristic distributions of regional cerebral blood flow changes in major depressive disorder patients: A pseudo-continuous arterial spin labeling (pCASL) study (2014)
  • Author(s): Ota M, Noda T, Sato N, Hattori K, Teraishi T, Hori H, Nagashima A, Shimoji K, Higuchi T, Kunugi H
  • Journal Title: Journal of Affective Disorders Volume: 165 Pages: 59
  • DOI: 10.1016/j.jad.2014.04.032
  • Peer Reviewed
• [Journal Article] QT is longer in drug-free patients with schizophrenia compared with age-matched healthy subjects (2014)
  • Author(s): Kumiko Fujii, Yuji Ozeki, Hiroaki Okayasu, Yumiko Takano, Takahiro Shinozaki, Hiroaki Hori, Masami Orui, Minoru Horie, Hiroshi Kunugi, Kazutaka Shimoda
  • Journal Title: PLOS ONE Volume: 9 Issue: 6 Pages: e98555-e98555
  • DOI: 10.1371/journal.pone.0098555
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Temperament and character in remitted and symptomatic patients with schizophrenia: Modulation by the COMT Val158Met genotype (2014)
  • Author(s): Hori H, Fujii T, Yamamoto N, Teraishi T, Ota M, Matsuo J, Kinoshita Y, Ishida I, Hattori K, Okazaki M, Arima K, Kunugi H
  • Journal Title: Journal of Psychiatric Research Volume: 56 Issue: 1 Pages: 82
  • DOI: 10.1016/j.jpsychires.2014.05.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between the common functional FKBP5 variant (rs1360780) and brain structure in a non-clinical population (2014)
  • Author(s): Fujii T, Ota M, Hori H, Hattori K, Teraishi T, Sasayama D, Higuchi T, Kunugi H
  • Journal Title: Journal of Psychiatric Research Volume: 58 Pages: 96
  • DOI: 10.1016/j.jpsychires.2014.07.009
  • Peer Reviewed
• [Journal Article] Altered coupling of regional cerebral blood flow and brain temperature in schizophrenia compared with bipolar disorder and healthy subjects (2014)
  • Author(s): M Ota, N Sato, K Sakai, M Okazaki, N Maikusa, K Hattori, H Hori, T Teraishi, K Ito, K Yamada, H Kunugi
  • Journal Title: Journal of Cerebral Blood Flow & Metabolism Volume: 34 Issue: 12 Pages: 1868
  • DOI: 10.1038/jcbfm.2014.151
  • Peer Reviewed
• [Journal Article] Relationship between lifetime suicide attempts and schizotypal traits in patients with schizophrenia (2014)
  • Author(s): Teraishi T, Hori H, Sasayama D, Matsuo J, Ogawa S, Ishida I, Nagashima A, Kinoshita Y, Ota M, Hattori K, Kunugi H
  • Journal Title: PLoS One Volume: 9 Issue: 9 Pages: e107739-e107739
  • DOI: 10.1371/journal.pone.0107739
  • Peer Reviewed / Open Access
• [Journal Article] Plasma L-tryptophan concentration in major depressive disorder: new data and meta-analysis (2014)
  • Author(s): Ogawa S, Fujii T, Koga N, Hori H, Teraishi T, Hattori K, Noda T, Higuchi T, Motohashi N, Kunugi H
  • Journal Title: Journal of Clinical Psychiatry Volume: 75 Issue: 09 Pages: 906-915
  • DOI: 10.4088/jcp.13r08908
  • Peer Reviewed
• [Journal Article] The common functional FKBP5 variant rs1360780 is associated with altered cognitive function in aged individuals (2014)
  • Author(s): Fujii T, Ota M, Hori H, Hattori K, Teraishi T, Matsuo J, Kinoshita Y, Ishida I, Nagashima A, Kunugi H
  • Journal Title: Scientific Reports Volume: 4 Issue: 1 Pages: 6696-6696
  • DOI: 10.1038/srep06696
  • Peer Reviewed / Open Access
• [Journal Article] A latent profile analysis of schizotypy, temperament and character in a nonclinical population: Association with neurocognition (2014)
  • Author(s): Hori H, Teraishi T, Sasayama D, Matsuo J, Kinoshita Y, Ota M, Hattori K, Kunugi H
  • Journal Title: Journal of Psychiatric Research Volume: 48 Issue: 1 Pages: 56
  • DOI: 10.1016/j.jpsychires.2013.10.006
  • Peer Reviewed
• [Journal Article] Psychological coping in depressed outpatients: Association with cortisol response to the combined dexamethasone/CRH test (2014)
  • Author(s): Hori H, Teraishi T, Ota M, Hattori K, Matsuo J, Kinoshita Y, Ishida I, Nagashima A, Koga N, Higuchi T, Kunugi H
  • Journal Title: Journal of Affective Disorders Volume: 152-154 Issue: 1 Pages: 441
  • DOI: 10.1016/j.jad.2013.10.013
  • Peer Reviewed
• [Journal Article] Benzodiazepines, benzodiazepine-like drugs, and typical antipsychotics impair manual dexterity in patients with schizophrenia (2014)
  • Author(s): Sasayama D, Hori H, Teraishi T, Hattori K, Ota M, Matsuo J, Kinoshita Y, Okazaki M, Arima K, Amano N, Higuchi T, Kunugi H
  • Journal Title: Journal of Psychiatric Research Volume: 49 Issue: 1 Pages: 37
  • DOI: 10.1016/j.jpsychires.2013.10.019
  • Peer Reviewed
• [Journal Article] ITIH3 polymorphism may confer susceptibility to psychiatric disorders by altering the expression levels of GLT8D1 (2014)
  • Author(s): Sasayama D, Hori H, Yamamoto N, Nakamura S, Teraishi T, Tatsumi M, Hattori K, Ota M, Higuchi T, Kunugi H
  • Journal Title: Journal of Psychiatric Research Volume: 50 Issue: 1 Pages: 79
  • DOI: 10.1016/j.jpsychires.2013.12.002
  • Peer Reviewed
• [Journal Article] Cross-cultural comparisons of attitudes toward schizophrenia amongst the general population and physicians: A series of web-based surveys in Japan and the United States (2014)
  • Author(s): Richards M, Hori H, Sartorius N, Kunugi H
  • Journal Title: Psychiatry Research Volume: 215 Issue: 2 Pages: 300
  • DOI: 10.1016/j.psychres.2013.12.012
  • Peer Reviewed
• [Journal Article] Pseudo-continuous arterial spin labeling MRI study of schizophrenic patients (2014)
  • Author(s): Ota M, Ishikawa M, Sato N, Okazaki M, Maikusa N, Hori H, Hattori K, Teraishi T, Ito K, Kunugi H
  • Journal Title: Schizophrenia Research Volume: 154 Issue: 1-3 Pages: 113
  • DOI: 10.1016/j.schres.2014.01.035
  • URL: https://pure.teikyo.jp/en/publications/7fda2226-03c0-4af1-917f-659a0cb1d3d8
  • Peer Reviewed
• [Journal Article] Effect of the common functional FKBP5 variant (rs1360780) on the hypothalamic-pituitary-adrenal axis and peripheral blood gene expression (2014)
  • Author(s): Fujii T, Hori H, Ota M, Hattori K, Teraishi T, Sasayama D, Yamamoto N, Higuchi T, Kunugi H.
  • Journal Title: Psychoneuroendocrinology. Volume: 42 Pages: 89
  • DOI: 10.1016/j.psyneuen.2014.01.007
  • Peer Reviewed
• [Journal Article] Cognitive effects of the ANK3 risk variants in patients with bipolar disorder and healthy individuals (2014)
  • Author(s): Hori H, Yamamoto N, Teraishi T, Ota M, Fujii T, Sasayama D, Matsuo J, Kinoshita Y, Hattori K, Nagashima A, Ishida I, Koga N, Higuchi T, Kunugi H.
  • Journal Title: J Affect Disord. Volume: 158 Pages: 90
  • DOI: 10.1016/j.jad.2014.02.008
  • Peer Reviewed
• [Journal Article] Effect of L-theanine on sensorimotor gating in healthy human subjects (2014)
  • Author(s): Ota M, Wakabayashi C, Matsuo J, Kinoshita Y, Hori H, Hattori K, Sasayama D, Teraishi T, Obu S, Ozawa H, Kunugi H
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 68 Issue: 5 Pages: 337
  • DOI: 10.1111/pcn.12134
  • Peer Reviewed
• [Journal Article] Discrimination between schizophrenia and major depressive disorder by magnetic resonance imaging of the female brain (2013)
  • Author(s): Ota M, Ishikawa M, Sato N, Hori H, Sasayama D, Hattori K, Teraishi T, Noda T, Obu S, Nakata Y, Higuchi T, Kunugi H
  • Journal Title: Journal of Psychiatric Research Volume: 47 Issue: 10 Pages: 1383
  • DOI: 10.1016/j.jpsychires.2013.06.010
  • Peer Reviewed
• [Journal Article] Possible association between common variants of the phenylalanine hydroxylase (PAH) gene and memory performance in healthy adults (2013)
  • Author(s): Teraishi T, Sasayama D, Hori H, Yamamoto N, Fujii T, Matsuo J, Nagashima A, Kinoshita Y, Hattori K, Ota M, Fujii S, Kunugi H.
  • Journal Title: Behav Brain Funct. Volume: 9 Issue: 1 Pages: 1-6
  • DOI: 10.1186/1744-9081-9-30
  • Peer Reviewed
• [Journal Article] Hypothalamic-pituitary-adrenal axis hyperactivity and brain differences in healthy women (2013)
  • Author(s): Ota M, Hori H, Sato N, Sasayama D, Hattori K, Teraishi T, Obu S, Nakata Y, Kunugi H
  • Journal Title: Neuropsychobiology Volume: 68 Issue: 4 Pages: 205
  • DOI: 10.1159/000355298
  • Peer Reviewed
• [Remarks] 独立行政法人国立精神・神経医療研究センター神経研究所 疾病研究第三部
  • URL: http://www.ncnp.go.jp/nin/guide/r3/achievement/index.html
• [Remarks] 独立行政法人国立精神・神経医療研究センター 神経研究所 疾病研究第三部
  • URL: http://www.ncnp.go.jp/nin/guide/r3/index.html