Continuity between schizophrenia and mood disorders: a comprehensive investigation of genes, cognition and schizotypal traits
Project/Area Number |
25861041
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Psychiatric science
|
Research Institution | National Center of Neurology and Psychiatry |
Principal Investigator |
HORI Hiroaki 独立行政法人国立精神・神経医療研究センター, 精神保健研究所 成人精神保健研究部, 室長 (10554397)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 統合失調症 / 気分障害 / 統合失調型パーソナリティ / 認知機能 / 遺伝子多型 / 遺伝子 / パーソナリティ |
Outline of Final Research Achievements |
We examined continuity and discontinuity between schizophrenia and mood disorders by investigating candidate gene variants, comprehensive cognitive functioning and personality characteristics in patients with schizophrenia, those with mood disorders and healthy control subjects. We have conducted a set of studies and obtained results suggesting genetic similarities between the two disorders. These results are considered to advance findings from relevant studies and contribute to elucidating the pathogenesis of schizophrenia and mood disorders.
|
Report
(3 results)
Research Products
(26 results)
-
-
[Journal Article] Personality in remitted major depressive disorder with single and recurrent episodes assessed with the Temperament and Character Inventory2015
Author(s)
Teraishi T, Hori H, Sasayama D, Matsuo J, Ogawa S, Ishida I, Nagashima A, Kinoshita Y, Ota M, Hattori K, Higuchi T, Kunugi H
-
Journal Title
Psychiatry and Clinical Neurosciences
Volume: 69
Issue: 1
Pages: 3-11
DOI
Related Report
Peer Reviewed
-
[Journal Article] White matter abnormalities in major depressive disorder with melancholic and atypical features: A diffusion tensor imaging study2015
Author(s)
Ota M, Noda T, Sato N, Hattori K, Hori H, Sasayama D, Teraishi T, Nagashima A, Obu S, Higuchi T, Kunugi H
-
Journal Title
Psychiatry and Clinical Neurosciences
Volume: 印刷中
Issue: 6
Pages: 360-368
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder2015
Author(s)
Ogawa S, Hattori K, Sasayama D, Yokota Y, Matsumura R, Matsuo J, Ota M, Hori H, Teraishi T, Yoshida S, Noda T, Ohashi Y, Sato H, Higuchi T, Motohashi N, Kunugi H
-
Journal Title
Sci Rep
Volume: 5
Issue: 1
Pages: 7796-7796
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Temperament and character in remitted and symptomatic patients with schizophrenia: modulation by the COMT Val158Met genotype2014
Author(s)
Hori H, Fujii T, Yamamoto N, Teraishi T, Ota M, Matsuo J, Kinoshita Y, Ishida I, Hattori K, Okazaki M, Arima K, Kunugi H
-
Journal Title
Journal of Psychiatric Research
Volume: 56
Pages: 82-89
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Altered coupling of regional cerebral blood flow and brain temperature in schizophrenia compared with bipolar disorder and healthy subjects2014
Author(s)
M Ota, N Sato, K Sakai, M Okazaki, N Maikusa, K Hattori, H Hori, T Teraishi, K Ito, K Yamada, H Kunugi
-
Journal Title
Journal of Cerebral Blood Flow & Metabolism
Volume: 34
Issue: 12
Pages: 1868-1873
DOI
Related Report
Peer Reviewed
-
[Journal Article] Relationship between lifetime suicide attempts and schizotypal traits in patients with schizophrenia2014
Author(s)
Teraishi T, Hori H, Sasayama D, Matsuo J, Ogawa S, Ishida I, Nagashima A, Kinoshita Y, Ota M, Hattori K, Kunugi H
-
Journal Title
PLoS One
Volume: 9
Issue: 9
Pages: e107739-e107739
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] Psychological coping in depressed outpatients: association with cortisol response to the combined dexamethasone/CRH test2014
Author(s)
Hori H, Teraishi T, Ota M, Hattori K, Matsuo J, Kinoshita Y, Ishida I, Nagashima A, Koga N, Higuchi T, Kunugi H
-
Journal Title
Journal of Affective Disorders
Volume: 152-154
Pages: 441-447
DOI
Related Report
Peer Reviewed
-
[Journal Article] Benzodiazepines, benzodiazepine-like drugs, and typical antipsychotics impair manual dexterity in patients with schizophrenia2014
Author(s)
Sasayama D, Hori H, Teraishi T, Hattori K, Ota M, Matsuo J, Kinoshita Y, Okazaki M, Arima K, Amano N, Higuchi T, Kunugi H
-
Journal Title
Journal of Psychiatric Research
Volume: 49
Pages: 37-42
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Cognitive effects of the ANK3 risk variants in patients with bipolar disorder and healthy individuals.2014
Author(s)
Hori H, Yamamoto N, Teraishi T, Ota M, Fujii T, Sasayama D, Matsuo J, Kinoshita Y, Hattori K, Nagashima A, Ishida I, Koga N, Higuchi T, Kunugi H.
-
Journal Title
J Affect Disord.
Volume: Epub
Pages: 10-10
DOI
Related Report
Peer Reviewed
-
[Journal Article] Effect of L-theanine on sensorimotor gating in healthy human subjects.2014
Author(s)
Ota M, Wakabayashi C, Matsuo J, Kinoshita Y, Hori H, Hattori K, Sasayama D, Teraishi T, Obu S, Ozawa H, Kunugi H
-
Journal Title
Psychiatry and Clinical Neurosciences
Volume: 68
Issue: 5
Pages: 337-343
DOI
Related Report
Peer Reviewed
-
[Journal Article] Discrimination between schizophrenia and major depressive disorder by magnetic resonance imaging of the female brain2013
Author(s)
Ota M, Ishikawa M, Sato N, Hori H, Sasayama D, Hattori K, Teraishi T, Noda T, Obu S, Nakata Y, Higuchi T, Kunugi H
-
Journal Title
Journal of Psychiatric Research
Volume: 47
Issue: 10
Pages: 1383-1388
DOI
Related Report
Peer Reviewed
-
[Journal Article] Possible association between common variants of the phenylalanine hydroxylase (PAH) gene and memory performance in healthy adults.2013
Author(s)
Teraishi T, Sasayama D, Hori H, Yamamoto N, Fujii T, Matsuo J, Nagashima A, Kinoshita Y, Hattori K, Ota M, Fujii S, Kunugi H.
-
Journal Title
Behav Brain Funct.
Volume: 9
Issue: 1
Pages: 1-6
DOI
Related Report
Peer Reviewed
-
-
-