Gamma band auditory response with neuroimaging in mood disorder

• Project/Area Number: 25861044
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: National Hospital Organization, Hizen Psychiatric Center
• Principal Investigator: HIRONORI Kuga 独立行政法人国立病院機構肥前精神医療センター(臨床研究部), その他部局等, 研究員 (50639903)
• Research Collaborator: UENO Takefumi 肥前精神医療センター, 臨床研究部長 (00441668) ; ORIBE Naoya 肥前精神医療センター, 脳生理, 神経画像研究室員 (70730498) ; KANBA Shigenobu 九州大学, 医学研究院, 教授 (50195187) ; ONITSUKA Toshiaki 九州大学, 医学研究院, 准教授 (00398059) ; HIRANO Yoji 九州大学, 医学研究院, 助教 (90567497) ; NAKAMURA Itta 九州大学, 医学研究院 ; OKAMOTO Hiroshi 九州大学, 医学研究院 (80724690)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 気分障害 / 双極性感情障害 / うつ病性障害 / 聴性定常反応 / 機能的MRI / 脳波 / 聴性定常反応（ASSR） / γ帯域同期性機能活動 / MEG / EEG / 双極性障害 / ASSR

Outline of Final Research Achievements

The aim of this study was to investigate the difference between bipolar disorder and major depressive disorder. The functioning of the neural circuitry was assessed using the auditory steady state response (ASSR). Left hemispheric neuronal deficits in response to speech sounds in patients with schizophrenia compared to healthy subjects and bipolar disorder.
Reduced 40 Hz auditory steady-state responses in patients with bipolar disorder compared to healthy subjects and major depressive disorder. We also found that cingulate gyrus might be involved in the abnormality of BOLD response to ASSR. It may be useful for discrimination of psychiatric diseases to use these auditory responses.

Research Products

• [Presentation] 統合失調症における聴性定常反応(ASSR)のγ帯域同期性機能活動に関するfMRI研究 (2015)
  • Author(s): 久我弘典、上野雄文、岡本宙、水原啓暁、中村一太、平野羊嗣、織部直弥、土本利架子、神庭重信、鬼塚俊明
  • Organizer: 第11回統合失調症研究会
  • Place of Presentation: 東京
  • Year and Date: 2015-02-14
• [Presentation] 統合失調症におけるASSR（聴性定常反応）の脳画像研究 (2014)
  • Author(s): 久我弘典、上野雄文、中村一太、織部直弥、岡本宙、平野羊嗣、神庭重信、鬼塚俊明
  • Organizer: 第44回日本臨床神経生理学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-19
• [Presentation] Gamma band auditory response with EEG and fMRI BOLD in first episode of schizophrenia (2014)
  • Author(s): Kuga H, Ueno T, Okamoto H, Nakamura I, Oribe N, Hirano Y, Kanba S, Onitsuka T
  • Organizer: International Early Psychosis Association 2014 Conference
  • Place of Presentation: Tokyo
  • Year and Date: 2014-11-17
• [Presentation] BOLD fMRI activation of 30-Hz auditory steady-state responses (2014)
  • Author(s): Okamoto H, Kuga H, Nakamura I, Oribe N, Fukushima S, Sejima K, Hirano Y, Hirano S, Oda Y, Tsuchimoto R, Onitsuka T, Kanba S, Ueno T
  • Organizer: Organization for Human Brain Mapping’s 2014 Annual Meeting
  • Place of Presentation: Hamburg
  • Year and Date: 2014-06-11
• [Presentation] BOLD fMRI activation for 30 Hz auditory steady state response (2014)
  • Author(s): Hiroshi Okamoto, Hironori Kuga, Naoya Oribe, Sho Fukushima, Kanako Sejima, Itta Nakamura, Yoji Hirano, Shogo Hirano, Rikako Tsuchimoto, Yuko Oda, Toshihiko Maekawa, Toshiaki Onitsuka, Shigenobu Kanba, Takefumi Ueno
  • Organizer: Organization for Human Brain Mapping's 2014 Annual Meeting
  • Place of Presentation: Hamburg, Germany