| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
In this study, I revealed the biological effect of intermittent hypoxia on the metastatic potential in tumor cells and the influence of X-irradiation on the surrounding cells as a by-stander effect as follows;
1.The preconditioning of tumor cells with intermittent hypoxia increased the migration and invasion potentials compared to normoxia and persistent hypoxia.
2.The conditioned medium of irradiated cell (CM) enhanced invasive ability of cancer cells. EGF mRNA and EGF concentrations was increased in X-irradiated cells and in the CM, respectively. Combined with the result that the CM activated EGFR, it is suggested that X-irradiation induces EGF expression of tumor cells, and increased EGF concentration in the CM, resulting in higher invasive ability of the surrounding cells.
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