The basic study for evaluation and control of the influence of intermittent hypoxia on metastatic potential of tumor cells
| Project/Area Number |
25861045
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Hokkaido University |
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Principal Investigator |
YASUI Hironobu 北海道大学, (連合)獣医学研究科, 助教 (10570228)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 間欠的低酸素 / 固形腫瘍 / 放射線 / 転移 |
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| Outline of Final Research Achievements |
In this study, I revealed the biological effect of intermittent hypoxia on the metastatic potential in tumor cells and the influence of X-irradiation on the surrounding cells as a by-stander effect as follows;
1.The preconditioning of tumor cells with intermittent hypoxia increased the migration and invasion potentials compared to normoxia and persistent hypoxia.
2.The conditioned medium of irradiated cell (CM) enhanced invasive ability of cancer cells. EGF mRNA and EGF concentrations was increased in X-irradiated cells and in the CM, respectively. Combined with the result that the CM activated EGFR, it is suggested that X-irradiation induces EGF expression of tumor cells, and increased EGF concentration in the CM, resulting in higher invasive ability of the surrounding cells.
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Report
(3 results)
Research Products
(52 results)
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[Journal Article] Radiosensitization of tumor cells through endoplasmic reticulum stress induced by PEGylated nanogel containing gold nanoparticles.2014
Author(s)
Yasui H, Takeuchi R, Nagane M, Meike S, Nakamura Y, Yamamori T, Ikenaka Y, Kon Y, Murotani H, Oishi M, Nagasaki Y, Inanami O
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Journal Title
Cancer Letters
Volume: 347
Issue: 1
Pages: 151-158
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Reoxygenation-induced nitric oxide mitigates tumor hypoxia and radioresistance in a murine SCCVII tumor model2013
Author(s)
Nagane M, Yasui H, Yamamori T, Zhao S, Kuge Y, Tamaki N, Kameya H, Nakamura H, Fujii H, Hirata H, Inanami O
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Journal Title
Biochem Biophys Res Commun
Volume: 437
Issue: 3
Pages: 420-425
DOI
Related Report
Peer Reviewed
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[Journal Article] EPR oxygen imaging and hyperpolarized (13) C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate.2013
Author(s)
Matsumoto S., Saito K., Yasui H., Morris H.D., Munasinghe J.P., Lizak M., Merkle H., Ardenkjaer-Larsen J.H., Choudhuri R., Devasahayam N., Subramanian S., Koretsky A.P., Mitchell J.B., and Krishna M.C.
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Journal Title
Magn. Reson. Med.
Volume: 69
Issue: 5
Pages: 1443-1450
DOI
Related Report
Peer Reviewed
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[Presentation] In vivo tumor extracellular pH monitoring using electron paramagnetic resonance2013
Author(s)
Goodwin J., Yachi K., Nagane M., Yasui H., Miyake Y., Inanami O., Bobko AA., Khramtsov V., Hirata H
Organizer
41st Annual ISOTT Meeting & EPR 2013
Place of Presentation
the Hanover Inn (Hanover, NH, USA)
Related Report
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