Development of short-range irradiation technique of Spot-Scanning proton therapy

• Project/Area Number: 25861048
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences (2014-2015); Hokkaido University (2013)
• Principal Investigator: Toramatsu Chie 国立研究開発法人放射線医学総合研究所, 重粒子医科学センター, 主任研究員 (90421825)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 陽子線治療 / スキャニング照射 / 粒子線治療 / 認証システム / 短飛程照射 / スポットスキャニング / 低エネルギー照射

Outline of Final Research Achievements

In scanned-beam proton therapy, the lateral and longitudinal size and the minimum achievable range, are influenced by beam optics, scattering media and drift spaces in the treatment unit. In this study, methods for adjusting the lateral and longitudinal spot size were investigated. Two methods were　nvestigated; one is the method of utilizing downstream plastic pre-absorbers located near a patient and the other is the method of utilizing beam　shaper/filter/absorbers in the treatment head.　The spot size adjustment was characterized using Monte Carlo simulations of a　modified commercial scanned-beam treatment head. Depend on this result, pre-absorbers were designed for clinical use to treat shallow seated tumor. And novel shape ripple filters were studied which are expected to have improved manufacturability. These findings suggest that this spot adjustment method may improve the quality of spot-canned proton treatments.

Research Products

• [Journal Article] What is the appropriate size criterion for proton radiotherapy for hepatocellular carcinoma? A dosimetric comparison of spot-scanning proton therapy versus intensity-modulated radiation therapy (2013)
  • Author(s): Chie Toramatsu,
  • Journal Title: Radiation Oncology Volume: 8 Issue: 1 Pages: 48-48
  • DOI: 10.1186/1748-717x-8-48
  • Peer Reviewed
• [Presentation] comissioning of spot scanning particle therapy system (2016)
  • Author(s): 高柳泰介
  • Organizer: PTCOG 2016
  • Place of Presentation: Prague
  • Year and Date: 2016-05-22
• [Presentation] A novel shape ridge filter for particle beam therapy (2016)
  • Author(s): 高柳泰介
  • Organizer: 医学物理学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-04-14
• [Presentation] Comissioning of Spot-Scanning Particle Therapy System (2014)
  • Author(s): 寅松千枝
  • Organizer: 重粒子線医工連携セミナー
  • Place of Presentation: 群馬大学重粒子線医学センター
  • Year and Date: 2014-04-24
  • Invited
• [Presentation] 陽子線治療システムのコミッショニング報告 (2014)
  • Author(s): 寅松千枝
  • Organizer: 日本医学物理学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] 陽子線治療システムビーム試験の報告 (2014)
  • Author(s): 寅松千枝
  • Organizer: 日本医学物理学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-04-10 – 2014-04-13
• [Presentation] Clinical Commissioning of Hokkaido University Hospital Proton Therapy Center (2014)
  • Author(s): Chie Toramatsu, Taeko Matsuura, Seishin Takao, Hideaki Nihongi, Takanori Yamada,Naoki Miyamoto, Shinichi Shimizu, Kikuo Umegaki and Hiroki Shirato
  • Organizer: 第107回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜(横浜市）
• [Presentation] 北海道大学病院陽子線治療システムのコミッショニング報告と現状 (2014)
  • Author(s): 寅松千枝
  • Organizer: 重粒子線医工連携セミナー
  • Place of Presentation: 群馬大学重粒子医科学センター(前橋市）
  • Invited
• [Presentation] Clinical Commissioning of Hokkaido University Hospital Proton Therapy Center (2014)
  • Author(s): Chie Toramatsu, Taeko Matsuura, Seishin Takao, Hideaki Nihongi, Takanori Yamada,Naoki Miyamoto, Shinichi Shimizu, Kikuo Umegaki and Hiroki Shirato
  • Organizer: PTCOG 53
  • Place of Presentation: Shanghai International Convention Center（Shanghai, China）
• [Patent(Industrial Property Rights)] 粒子線治療システムおよびリッジフィルタならびにリッジフィルタの製造方法 (2013)
  • Inventor(s): 寅松千枝,松浦妙子,宮本直樹,二本木英明,梅垣菊男,平田雄一
  • Industrial Property Rights Holder: 寅松千枝,松浦妙子,宮本直樹,二本木英明,梅垣菊男,平田雄一
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-260896
  • Filing Date: 2013-12-18