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Development of an applicator for treating shallow and moving tumors with respiratory-gated spot-scanning proton therapy using real-time image guidance

Research Project

Project/Area Number 25861049
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

TAEKO Matsuura  北海道大学, 大学病院, 助教 (90590266)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords陽子線治療 / スポットスキャニング照射 / 呼吸性移動 / スポットスキャニング法 / 呼吸性移動対策
Outline of Final Research Achievements

An applicator was developed for treating shallow and moving tumors (e.g., lung tumors) with respiratory-gated spot-scanning proton therapy using real-time image guidance. The mechanical design was considered such that the Bragg peaks are placed at the patient surface while a sufficient field of view (FOV) of fluoroscopic X-rays was maintained during the proton beam delivery. To reduce the treatment time maintaining the robustness of the dose distribution with respect to motion, a mini-ridge filter (MRF) was sandwiched between two energy absorbers. The measurements were performed to obtain data for beam modeling and to verify that a pencil beam dose distribution does not vary with its lateral position. The treatment planning study of lung patients showed that indeed the spot-scanning proton beam can be delivered to shallow and moving tumors in a sufficiently short time and with high accuracy by installing the developed applicator at the treatment nozzle.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Preliminary analysis for integration of spot-scanning proton beam therapy and real-time imaging and gating.2014

    • Author(s)
      Shimizu S, Matsuura T, Umezawa M, Hiramoto K, Miyamoto N, Umegaki K, Shirato H
    • Journal Title

      Physica Medica

      Volume: 30 Issue: 5 Pages: 555-558

    • DOI

      10.1016/j.ejmp.2014.04.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A proton beam therapy system dedicated to spot-scanning increases accuracy with moving tumors by real-time imaging and gating and reduces equipment size.2014

    • Author(s)
      Shimizu S, Miyamoto N, Matsuura T, Fujii Y, Umezawa M, Umegaki K, Hiramoto K, Shirato H
    • Journal Title

      PLoS One

      Volume: 9(4) Issue: 4 Pages: 94971-94977

    • DOI

      10.1371/journal.pone.0094971

    • NAID

      120005438246

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Integration of a real-time tumor monitoring system into gated proton spot-scanning beam therapy: An initial phantom study using patient tumor trajectory data.2013

    • Author(s)
      Taeko Matsuura, Naoki Miyamoto, Shinichi Shimizu, Yusuke Fujii, Masumi Umezawa, Seishin Takao, Hideaki Nihongi, Chie Toramatsu, Kenneth Sutherland, Ryusuke Suzuki, Masayori Ishikawa, Rumiko Kinoshita, Kenichiro Maeda, Kikuo Umegaki, Hiroki Shirato
    • Journal Title

      Medical Physics

      Volume: 40(7) Issue: 7 Pages: 71729-71729

    • DOI

      10.1118/1.4810966

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Development of An Applicator for Treating Shallow and Moving Tumor with Respiratory-gated Spot-Scanning Proton Therapy Using Real-Time Image Guidance2015

    • Author(s)
      Taeko Matsuura, Yusuke Fujii, Seishin Takao, Takahiro Yamada, Yuka Matsuzaki, Naoki Miyamoto, Taisuke Takayanagi, Shinichiro Fujitaka, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
    • Organizer
      AAPM57th
    • Place of Presentation
      Anaheim Convention Center (Anaheim, USA)
    • Year and Date
      2015-07-12 – 2015-07-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of a short range applicator for real-time-image gated proton beam therapy2015

    • Author(s)
      Taeko Matsuura, Yusuke Fujii, Seishin Takao, Yuka Matsuzaki, Takahiro Yamada, Yuto Matsuo, Shinichiro Fujitaka, Taisuke Takayanagi, Kikuo Umegaki, Hiroki Shirato
    • Organizer
      第109回日本医学物理学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2015-04-16 – 2015-04-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Improvement of Accuracy of Spot-Scanning Proton Beam Delivery for Liver Tumor by Real-Time Tumor-Monitoring and Gating System:A Simulation Study2014

    • Author(s)
      Taeko Matsuura, Shinichi Shimizu, Naoki Miyamoto, Seishin Takao, Chie Toramatsu, Hideaki Nihongi, Takahiro Yamada, Yusuke Fujii, Masumi Umezawa, Kikuo Umegaki, Hiroki Shirato
    • Organizer
      AAPM56th
    • Place of Presentation
      Austin Convention Center (Austin, USA)
    • Year and Date
      2014-07-20 – 2014-07-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effectiveness of an in-gate beam tracking method in spot-scanning proton therapy2013

    • Author(s)
      T Matsuura, Y Fujii, R Fujimoto, M Umezawa,N Miyamoto, K Sutherland, S Takao, H Nihongi, C Toramatsu, S Shimizu, K Umegaki, H Shirato
    • Organizer
      AAPM 55th annual meeting
    • Place of Presentation
      Indiana Convention Center, Indiana, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Improvement of Accuracy of Spot-Scanning Proton Beam Delivery for Liver Tumor by Real-Time Tumor-Monitoring and Gating System: A Simulation Study

    • Author(s)
      Taeko Matsuura, Shinichi Shimizu, Naoki Miyamoto, Seishin Takao, Chie Toramatsu, Hideaki Nihongi, Takahiro Yamada, Yusuke Fujii, Masumi Umezawa, Kikuo Umegaki, Hiroki Shirato
    • Organizer
      AAPM 56th annual meeting
    • Place of Presentation
      Austin Convention Center, Austin, TX, USA
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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