Development of an applicator for treating shallow and moving tumors with respiratory-gated spot-scanning proton therapy using real-time image guidance

• Project/Area Number: 25861049
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: TAEKO Matsuura 北海道大学, 大学病院, 助教 (90590266)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 陽子線治療 / スポットスキャニング照射 / 呼吸性移動 / スポットスキャニング法 / 呼吸性移動対策

Outline of Final Research Achievements

An applicator was developed for treating shallow and moving tumors (e.g., lung tumors) with respiratory-gated spot-scanning proton therapy using real-time image guidance. The mechanical design was considered such that the Bragg peaks are placed at the patient surface while a sufficient field of view (FOV) of fluoroscopic X-rays was maintained during the proton beam delivery. To reduce the treatment time maintaining the robustness of the dose distribution with respect to motion, a mini-ridge filter (MRF) was sandwiched between two energy absorbers. The measurements were performed to obtain data for beam modeling and to verify that a pencil beam dose distribution does not vary with its lateral position. The treatment planning study of lung patients showed that indeed the spot-scanning proton beam can be delivered to shallow and moving tumors in a sufficiently short time and with high accuracy by installing the developed applicator at the treatment nozzle.

Research Products

• [Journal Article] Preliminary analysis for integration of spot-scanning proton beam therapy and real-time imaging and gating. (2014)
  • Author(s): Shimizu S, Matsuura T, Umezawa M, Hiramoto K, Miyamoto N, Umegaki K, Shirato H
  • Journal Title: Physica Medica Volume: 30 Issue: 5 Pages: 555-558
  • DOI: 10.1016/j.ejmp.2014.04.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A proton beam therapy system dedicated to spot-scanning increases accuracy with moving tumors by real-time imaging and gating and reduces equipment size. (2014)
  • Author(s): Shimizu S, Miyamoto N, Matsuura T, Fujii Y, Umezawa M, Umegaki K, Hiramoto K, Shirato H
  • Journal Title: PLoS One Volume: 9(4) Issue: 4 Pages: 94971-94977
  • DOI: 10.1371/journal.pone.0094971
  • NAID: 120005438246
  • Peer Reviewed / Open Access
• [Journal Article] Integration of a real-time tumor monitoring system into gated proton spot-scanning beam therapy: An initial phantom study using patient tumor trajectory data. (2013)
  • Author(s): Taeko Matsuura, Naoki Miyamoto, Shinichi Shimizu, Yusuke Fujii, Masumi Umezawa, Seishin Takao, Hideaki Nihongi, Chie Toramatsu, Kenneth Sutherland, Ryusuke Suzuki, Masayori Ishikawa, Rumiko Kinoshita, Kenichiro Maeda, Kikuo Umegaki, Hiroki Shirato
  • Journal Title: Medical Physics Volume: 40(7) Issue: 7 Pages: 71729-71729
  • DOI: 10.1118/1.4810966
  • Peer Reviewed
• [Presentation] Development of An Applicator for Treating Shallow and Moving Tumor with Respiratory-gated Spot-Scanning Proton Therapy Using Real-Time Image Guidance (2015)
  • Author(s): Taeko Matsuura, Yusuke Fujii, Seishin Takao, Takahiro Yamada, Yuka Matsuzaki, Naoki Miyamoto, Taisuke Takayanagi, Shinichiro Fujitaka, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
  • Organizer: AAPM57th
  • Place of Presentation: Anaheim Convention Center (Anaheim, USA)
  • Year and Date: 2015-07-12 – 2015-07-16
• [Presentation] Development of a short range applicator for real-time-image gated proton beam therapy (2015)
  • Author(s): Taeko Matsuura, Yusuke Fujii, Seishin Takao, Yuka Matsuzaki, Takahiro Yamada, Yuto Matsuo, Shinichiro Fujitaka, Taisuke Takayanagi, Kikuo Umegaki, Hiroki Shirato
  • Organizer: 第109回日本医学物理学会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2015-04-16 – 2015-04-19
• [Presentation] Improvement of Accuracy of Spot-Scanning Proton Beam Delivery for Liver Tumor by Real-Time Tumor-Monitoring and Gating System:A Simulation Study (2014)
  • Author(s): Taeko Matsuura, Shinichi Shimizu, Naoki Miyamoto, Seishin Takao, Chie Toramatsu, Hideaki Nihongi, Takahiro Yamada, Yusuke Fujii, Masumi Umezawa, Kikuo Umegaki, Hiroki Shirato
  • Organizer: AAPM56th
  • Place of Presentation: Austin Convention Center (Austin, USA)
  • Year and Date: 2014-07-20 – 2014-07-24
• [Presentation] Effectiveness of an in-gate beam tracking method in spot-scanning proton therapy (2013)
  • Author(s): T Matsuura, Y Fujii, R Fujimoto, M Umezawa,N Miyamoto, K Sutherland, S Takao, H Nihongi, C Toramatsu, S Shimizu, K Umegaki, H Shirato
  • Organizer: AAPM 55th annual meeting
  • Place of Presentation: Indiana Convention Center, Indiana, USA
• [Presentation] Improvement of Accuracy of Spot-Scanning Proton Beam Delivery for Liver Tumor by Real-Time Tumor-Monitoring and Gating System: A Simulation Study
  • Author(s): Taeko Matsuura, Shinichi Shimizu, Naoki Miyamoto, Seishin Takao, Chie Toramatsu, Hideaki Nihongi, Takahiro Yamada, Yusuke Fujii, Masumi Umezawa, Kikuo Umegaki, Hiroki Shirato
  • Organizer: AAPM 56th annual meeting
  • Place of Presentation: Austin Convention Center, Austin, TX, USA