| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In this study, we investigated molecular mechanisms to improve the radiation therapy by targeting specific molecules which are involved in not only preservation of the functions in normal cell structure but also suppressing tumor growth, recurrence and metastasis. To find candidate genes, we performed microarray analysis in a mammary epithelial cell line which has basal polarity, or invasive breast cancer cell lines in three-dimensional laminin rich extracellular matrix (3D lrECM). We found that β1-integrin and its downstream molecules are involved in the disruption of basal polarity structure and invasive transition on non-malignant mammary epithelial cells in 3D lrECM. In addition, we also found that up-regulated integrin expression on the cell surface may have important roles in the invasive activity after radiation treatment in breast cancer cells.
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