Establishment of "balloon occluded NBCA embolization technique"

Research Project

Project/Area Number	25861051
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	Hokkaido University
Principal Investigator	Abo Daisuke 北海道大学, 大学病院, 助教 (30399844)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	NBCA / 画像下治療 / 塞栓術 / flow control / microballoon / n-butyl 2-cyanoacrylate / balloon閉塞 / 血管塞栓術
Outline of Final Research Achievements	A n-butyl-2-cyanoacrylate(NBCA) is liquid embolic material which provides a strong and instant embolic effect due to formation of glue cast in the blood vessel, promoted by exposure to blood.The one of disadvantages of embolization with NBCA is a difficulty of accurate control of the site of embolization in the vessel, because the site of cast formation is strongly affected by the polymerization time. We found it possible to control the site of embolization by embolization technique under flow control, followed by glucose injection with microballoon catheter, compared with ordinary embolization technique under non-flow control in swine model.