Imaging method and evaluation method of 3 Tesla MRI diffusion weighted imaging as breast cancer biomarker

Research Project

Project/Area Number	25861058
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	Tohoku University
Principal Investigator	Mori Naoko 東北大学, 大学病院, 助教 (90535064)
Project Period (FY)	2013-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	拡散強調画像 / 乳癌 / MRI / 標準化 / 高分解能 / 再現性 / ヒストグラム解析 / 標本画像
Outline of Final Research Achievements	In order to clarify the usefulness and measurement method of diffusion weighted images in breast cancer, we showed that the apparent diffusion coefficient (ADC) was significantly different between noninvasive cancer (DCIS) and invasive cancer. Among invasive cancers, a negative correlation between ADC value and cell proliferation index (Ki-Labeling index) was confirmed. As a measurement method, histogram analysis of the entire tumor volume was performed and compared with the usual ROI method. The average value of the ROI method was confirmed to be a sufficient method as well as the histogram parameters.