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Role of Pax6 on constructing brain higher function: in vivo brain imaging study on Pax6 mutant rats

Research Project

Project/Area Number 25861059
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionTohoku University

Principal Investigator

HIRAOKA KOTARO  東北大学, サイクロトロン・ラジオアイソトープセンター, 助教 (70586049)

Research Collaborator OSUMI Noriko  東北大学, 大学院医学系研究科, 教授 (00220343)
SUMIYOSHI Akira  東北大学, 加齢医学研究所, 助教 (80612530)
KAWASHIMA Ryuta  東北大学, 加齢医学研究所, 教授 (90250828)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsPax6 / 転写制御因子 / 高次脳機能 / 自閉症 / 脳形態 / 行動異常 / 脳高次機能 / 小動物用MRI / 組織学的解析 / 動物実験 / 核磁気共鳴画像法(MRI) / 陽電子放射断層撮影(PET)
Outline of Final Research Achievements

Pax6 is a transcription factor which is crucial for the development of the central nervous system. It is thought to be an upstream of gene networks involved in brain patterning, neural migration, and neural circuit formation. Patients with PAX6 mutation have been reported to have mental retardation, frotal lobe dysfunction, or autism occationally. In this study, we evaluated morphology of the brain in Pax6 mutant and wild type rats using small animal magnetic resonance imaging (MRI). We found decreased volumes of the isocortex, hippocampus, amygdala, thalamus, midbrain, and corpus callosum in Pax6 mutant rats compared to wild type rats. The results shed some light on the role of Pax6 on constructing brain higher function.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (17 results)

All 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (11 results)

  • [Journal Article] Brain histamine H1 receptor occupancy measured by PET after oral administration of levocetirizine, a non-sedating antihistamine.2015

    • Author(s)
      Hiraoka K, Tashiro M, Grobosch T, Maurer M, Oda K, Toyohara J, Ishii K, Ishiwata K, Yanai K.
    • Journal Title

      Expert Opin Drug Saf.

      Volume: 14 Issue: 2 Pages: 199-206

    • DOI

      10.1517/14740338.2015.989831

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Muscle activity pattern of the shoulder external rotators differs in adduction and abduction: an analysis using positron emission tomography.2014

    • Author(s)
      Kurokawa D, Sano H, Nagamoto H, Omi R, Shinozaki N, Watanuki S, Kishimoto KN, Yamamoto N, Hiraoka K, Tashiro M, Itoi E.
    • Journal Title

      J Shoulder Elbow Surg.

      Volume: 23 Issue: 5 Pages: 658-664

    • DOI

      10.1016/j.jse.2013.12.021

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 特発性正常圧水頭症の疫学・診断・病態に関する研究2013

    • Author(s)
      平岡宏太良
    • Journal Title

      東北醫學雑誌

      Volume: 125 Pages: 79-82

    • Related Report
      2013 Research-status Report
  • [Journal Article] 特発性正常圧水頭症の脳イメージングによる研究2013

    • Author(s)
      平岡宏太良
    • Journal Title

      CYRIC News

      Volume: 53 Pages: 4-7

    • Related Report
      2013 Research-status Report
  • [Journal Article] Evaluation of the biodistribution and radiation dosimetry of the ^(11)F-labelled amyloid imaging probe [^(18)F]F ACT in humans2013

    • Author(s)
      Shidahara M, Tashiro M, Okamura N, Furumoto S, Furukawa K, Watanuki S, Hiraoka K, Miyake M, Iwata R, Tamura H, Arai H, Kudo Y, Y anai K
    • Journal Title

      EJNMMI Res

      Volume: 3 Issue: 1 Pages: 32-32

    • DOI

      10.1186/2191-219x-3-32

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Histamine H1 receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine : a positron emission tomography study in healthy volunteers2013

    • Author(s)
      Sato H, Ito C, Tashiro M, Hiraoka K, Shibuya K, Funaki Y, Iwata R, Matsuoka H, Yanai K.
    • Journal Title

      Psychopharmacology (Berl)

      Volume: 230 (2) Issue: 2 Pages: 227-34

    • DOI

      10.1007/s00213-013-3146-1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 特発性正常圧水頭症における脳内アミロイド沈着とシャント術による治療反応性の関連2014

    • Author(s)
      平岡宏太良
    • Organizer
      第54回日本核医学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-06 – 2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 特発性正常圧水頭症における脳内アミロイド沈着とシャント術による治療反応性の関連2014

    • Author(s)
      平岡宏太良
    • Organizer
      第37回神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus2014

    • Author(s)
      Kotaro Hiraoka
    • Organizer
      Hydrocephalus 2014
    • Place of Presentation
      Bristol, England
    • Year and Date
      2014-09-06 – 2014-09-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 研究紹介2014

    • Author(s)
      平岡宏太良
    • Organizer
      第3回腫瘍分子イメージングセミナー
    • Place of Presentation
      千歳
    • Year and Date
      2014-08-02 – 2014-08-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 特発性正常圧水頭症における脳内アミロイド沈着とシャント術による治療反応性の関連2014

    • Author(s)
      平岡宏太良
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] iNPHにおける脳内アミロイド沈着とシャント術による治療反応性の関連2014

    • Author(s)
      平岡宏太良
    • Organizer
      第15回日本正常圧水頭症学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 特発性正常圧水頭症における脳内アミロイド沈着とシャント術による治療反応性の関連2014

    • Author(s)
      平岡宏太良
    • Organizer
      厚生労働省認知症対策総合研究事業 アミロイドイメージングを用いたアルツハイマー病発症リスク予測法の実用化に関する多施設臨床研究 平成25年度班会議
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 11C-doxepin-PETによる抗ヒスタミン薬levocetirizineの脳内ヒスタミンH1受容体占拠率の測定2013

    • Author(s)
      平岡宏太良
    • Organizer
      CYRIC共同利用実験第34回研究報告会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 11C-doxepin-PETによる抗ヒスタミン薬levocetirizineの脳内ヒスタミンH1受容体占拠率の測定2013

    • Author(s)
      平岡宏太良
    • Organizer
      第53回日本核医学学術総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 11C-doxepin-PETを用いた抗ヒスタミン薬levocetirizineの脳内ヒスタミンH1受容体占拠率の測定2013

    • Author(s)
      平岡宏太良
    • Organizer
      第129回日本医学放射線学会 北日本地方会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report
  • [Presentation] 11C-doxepinを用いたPETによる抗ヒスタミン薬levocetirizineの脳内ヒスタミンH1受容体占拠率の測定2013

    • Author(s)
      平岡宏太良
    • Organizer
      NEURO2013
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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