Proton beam therapy for pediatric tumor

• Project/Area Number: 25861064
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: University of Tsukuba
• Principal Investigator: MIZUMOTO MASASHI 筑波大学, 医学医療系, 講師 (20512388)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 陽子線治療 / 放射線治療 / 小児腫瘍 / 晩期有害事象 / 脳腫瘍

Outline of Final Research Achievements

I collect and analyze the result of proton beam therapy for pediatric tumor. The association between late toxicity and proton beam therapy was verified. This analysis made clear that proton beam therapy for pediatric tumor could reduce the dose of normal brain compared to photon radiotherapy such as 3D-CRT and Intensity-modulated radiation therapy. As for body trunk tumor, I compared proton beam therapy to 3D-CRT and Intensity-modulated radiation therapy.

Research Products

• [Journal Article] Proton beam therapy for pediatric malignancies: A retrospective observational multicenter study in Japan (2016)
  • Author(s): M.Mizumoto, S. Murayama, T. Akimoto, Y. Demizu, T. Fukushima, Y. Ishida, Y. Oshiro, H. Numajiri, H. Fuji, T. Okumura, H. Shirato, H. Sakurai
  • Journal Title: Cancer medicine Volume: in press
  • NAID: 120007129524
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Takizawa D, Oshiro Y, Mizumoto M, Fukushima H, Fukushima T, Sakurai H: Proton beam therapy for a patient with large rhabdomyosarcoma of the body trunk. (2015)
  • Author(s): Takizawa D, Oshiro Y, Mizumoto M, Fukushima H, Fukushima T, Sakurai H
  • Journal Title: Italian journal of pediatrics Volume: 41 Pages: 90-90
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Tailor-made treatment combined with proton beam therapy for children with genitourinary/pelvic rhabdomyosarcoma. (2015)
  • Author(s): Fukushima H, Fukushima T, Sakai A, Suzuki R, Kobayashi C, Oshiro Y, Mizumoto M, Hoshino N, Gotoh C, Urita Y, Komuro H, Kaneko M, Sekido N, Masumoto K, Sakurai H, Sumazaki R
  • Journal Title: Rep Pract Oncol Radiother Volume: 33 Pages: 303-310
  • Peer Reviewed / Open Access
• [Journal Article] Proton beam therapy for pediatric ependymoma. (2015)
  • Author(s): Mizumoto M, Oshiro Y, Takizawa D, Fukushima T, Fukushima H, Yamamoto T, Muroi A, Okumura T, Tsuboi K, Sakurai H
  • Journal Title: Pediatric International Volume: 57 Pages: 567-571
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Preparation of pediatric patients for treatment with proton beam therapy. (2015)
  • Author(s): Mizumoto M, Oshiro Y, Ayuzawa K, Miyamoto T, Okumura T, Fukushima T, Fukushima H, Ishikawa H, Tsuboi K, Sakurai H
  • Journal Title: Radiother Oncol Volume: 114 Pages: 245-248
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of dose-volume histograms between proton beam and X-ray conformal radiotherapy for locally advanced non-small-cell lung cancer. (2015)
  • Author(s): Ohno T, Oshiro Y, Mizumoto M, Numajiri H, Ishikawa H, Okumura T, Terunuma T, Sakae T, Sakurai H.
  • Journal Title: J Radiat Res Volume: 56 Issue: 1 Pages: 128-133
  • DOI: 10.1093/jrr/rru082
  • NAID: 120007130349
  • Peer Reviewed / Open Access
• [Journal Article] Preparation of pediatric patients for treatment with proton beam therapy. (2015)
  • Author(s): Mizumoto M, Oshiro Y, Ayuzawa K, Miyamoto T, Okumura T, Fukumitsu N, Fukushima T, Ishikawa H, Sakurai H
  • Journal Title: Radiather Oncol Volume: 114 Issue: 2 Pages: 245-248
  • DOI: 10.1016/j.radonc.2015.01.007
  • Peer Reviewed / Open Access
• [Journal Article] Proton Beam Therapy for Pediatric Patients with Ependymoma. (2015)
  • Author(s): Mizumoto M, Oshiro Y, Takizawa D, Fukushima T, Fukushima H, Yamamoto T, Muroi A, Okumura T, Tsuboi K, Sakurai H.
  • Journal Title: Pediatr Int. Volume: 0 Issue: 4 Pages: 567-571
  • DOI: 10.1111/ped.12624
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] High-dose concurrent chemo-proton therapy for Stage III NSCLC: preliminary results of a Phase II study (2014)
  • Author(s): Y Oshiro, T Okumura, K kurishima, S Honma, M Mizumoto, H Ishikawa, M Onizuka, M Sakai, Y Goto, N Hizawa, Y Sato, H Sakurai
  • Journal Title: J Radiat Res Volume: 55 Issue: 5 Pages: 959-965
  • DOI: 10.1093/jrr/rru034
  • Peer Reviewed / Open Access
• [Journal Article] Association between pretreatment retention rate of indocyanine green 15min after administration and life prognosis in patients with HCC treated by proton beam therapy. (2014)
  • Author(s): Mizumoto M, Oshiro Y, Okumura T, Fukuda K, Fukumitsu N, Abei M, et al.
  • Journal Title: Radiother Oncol Volume: 113 Issue: 1 Pages: 54-59
  • DOI: 10.1016/j.radonc.2014.08.015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Proton beam therapy for a patient with a giant thymic carcinoid tumor and severe superior vena cava syndrome. (2014)
  • Author(s): Sugawara K, Mizumoto M, Numajiri H, Ohno T, Ohnishi K, Ishikawa H, Okumura T, Sakurai H.
  • Journal Title: Rare Tumors Volume: 13 Issue: 2 Pages: 5177-5177
  • DOI: 10.4081/rt.2014.5177
  • Peer Reviewed / Open Access
• [Journal Article] Outcomes and prognostic factors for recurrence after high-dose proton beam therapy for centrally and peripherally located stage I non-small-cell lung cancer (2014)
  • Author(s): Kanemoto A, Okumura T, Ishikawa H, Mizumoto M, Oshiro Y, Kurishima K, Homma S, Hashimoto T, Ohkawa A, Numajiri H, Ohno T, Moritake T, Tsuboi K, Sakae T, Sakurai H
  • Journal Title: Clin Lung Cancer Volume: 15 Issue: 2 Pages: e7-e12
  • DOI: 10.1016/j.cllc.2013.11.002
  • Peer Reviewed
• [Journal Article] A phase I study on combined therapy with proton-beam radiotherapy and in situ tumor vaccination for locally advanced recurrent hepatocellular carcinoma (2013)
  • Author(s): Abei M, Okumura T, Fukuda K, Hashimoto T, Araki M, Ishige K, Hyodo I, Kanemoto A, Numajiri H, Mizumoto M, Sakae T, Sakurai H, Zenkoh J, Ariungerel G, Sogo Y, Ito A,Ohno T, Tsuboi K
  • Journal Title: Radiat Oncol Volume: 16 Issue: 1 Pages: 239-239
  • DOI: 10.1186/1748-717x-8-239
  • Peer Reviewed
• [Journal Article] Dose-volume histogram analysis for risk factors of radiation-induced rib fracture after hypofractionated proton beam therapy for hepatocellular carcinoma (2013)
  • Author(s): Kanemoto A, Mizumoto M, Okumura T, Takahashi H, Hashimoto T, Oshiro Y, Fukumitsu N, Moritake T, Tsuboi K, Sakae T, Sakurai H
  • Journal Title: Acta Oncol Volume: 52(3) Issue: 3 Pages: 538-44
  • DOI: 10.3109/0284186x.2012.718094
  • Peer Reviewed
• [Journal Article] Clinical results of proton beam therapy for advanced neuroblastoma (2013)
  • Author(s): Oshiro Y, Mizumoto M, Okumura T, Sugahara S, Fukushima T, Ishikawa H, Nakao T, Hashimoto T, Tsuboi K, Ohkawa H, Kaneko M, Sakurai H
  • Journal Title: Radiat Oncol Volume: 12 Issue: 1 Pages: 142-142
  • DOI: 10.1186/1748-717x-8-142
  • NAID: 120007136889
  • Peer Reviewed
• [Journal Article] Proton beam therapy for unresectable hepatoblastoma in children: survival in one case (2013)
  • Author(s): Oshiro Y, Okumura T, Mizumoto M, Fukushima T, Ishikawa H, Hashimoto T, Tsuboi K, Kaneko M, Sakurai H
  • Journal Title: Acta Oncol Volume: 52(3) Issue: 3 Pages: 600-3
  • DOI: 10.3109/0284186x.2012.760849
  • Peer Reviewed
• [Journal Article] Proton beam therapy for malignancy in Bloom syndrome (2013)
  • Author(s): Mizumoto M, Hashii H, Senarita M, Sakai S, Wada T, Okumura T, Tsuboi K, Sakurai H
  • Journal Title: Strahlenther Onkol Volume: 189 Issue: 4 Pages: 335-338
  • DOI: 10.1007/s00066-012-0274-1
  • Peer Reviewed
• [Journal Article] Reirradiation for recurrent malignant brain tumor with radiotherapy or proton beam therapy. Technical considerations based on experience at a single institution (2013)
  • Author(s): Mizumoto M, Okumura T, Ishikawa E, Yamamoto T, Takano S, Matsumura A, Oshiro Y, Ishikawa H, Sakurai H, Tsuboi K
  • Journal Title: Strahlenther Onkol Volume: 189 Issue: 8 Pages: 656-663
  • DOI: 10.1007/s00066-013-0390-6
  • Peer Reviewed
• [Journal Article] Comparison of adverse effects of proton and X-ray chemoradiotherapy for oesophageal cancer using an adaptive dose-volume histogram analysis (2013)
  • Author(s): Makishima H, Ishikawa H, Terunuma T, Hashimoto T, Yamanashi K, Sekiguchi T, Mizumoto M, Okumura T, Tsuboi K, Sakurai H
  • Journal Title: Eur J Cancer Volume: 49
  • Peer Reviewed
• [Journal Article] Proton beam therapy for a patients wioth large rhabdomyosarcoma of the body trunk (2013)
  • Author(s): Takizawa D, Oshiro Y, Okumura T, Mizumoto M, Fukushima T, Ishikawa H, Tsuboi K, Kaneko M, Sakurai H
  • Journal Title: Pediatr Blood Cancer Volume: 60 Pages: 93-93
  • Peer Reviewed
• [Presentation] 脳腫瘍、頭蓋底腫瘍に対する陽子線治療 (2014)
  • Author(s): 水本斉志、坪井康次、奥村敏之，林 靖孝、室伏景子、大西かよ子、福光延吉、粟飯原輝人、石川仁、櫻井英幸
  • Organizer: 日本放射線腫瘍学会第27回大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-12-11 – 2014-12-13
• [Presentation] Preparation and behavioral training for pediatric patients treated by ptoton therapy. (2014)
  • Author(s): Mizumoto M, Ayuzawa K, Miyamoto T, Oshiro T, Okumura T, Fukushima T, Ishikawa H, Tsuboi K, Sakurai H
  • Organizer: 46th Congress of the International Society of Paediatric Oncology
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2014-10-22 – 2014-10-25
• [Presentation] 小児がん (2014)
  • Author(s): 水本斉志
  • Organizer: 第16回放射線腫瘍学セミナー
  • Place of Presentation: 日光
  • Year and Date: 2014-08-30
  • Invited
• [Presentation] 肝細胞癌に対する陽子線治療における予後と治療前肝機能（ICG15分停滞率）の関連性 (2014)
  • Author(s): 水本斉志、大城佳子、奥村敏之、福光延吉、石川仁、安部井誠人、福田邦明、石毛和紀、坪井康次、櫻井英幸
  • Organizer: 第50回日本肝癌研究会
  • Place of Presentation: 京都
  • Year and Date: 2014-06-05 – 2014-06-06
• [Presentation] Association between life prognosis and pretreatment ICG 15 for the patients with HCC treated by proton beam therapy (2014)
  • Author(s): Mizumoto M, Oshiro Y, Okumura T, Fukumitsu N, Ishikawa H, Ohnishi k, Numajiri H, Aihara T, Tsuboi K, Sakurai H
  • Organizer: ESTRO 33
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2014-04-04 – 2014-04-08
• [Presentation] 頭頸部進行がん新鮮例に対する新規粒子線治療の可能性 －硼素中性子捕捉療法に対する筑波大学の取り組みと今後の展望－ (2014)
  • Author(s): 粟飯原輝人, 和田哲郎, 石川仁, 福光延吉, 奥村敏之, 大西かよ子, 水本斉志, 沼尻晴子, 熊田博明, 平塚純一, 原晃 and 櫻井英幸
  • Organizer: 第23回茨城がん学会
  • Place of Presentation: つくば
  • Invited
• [Presentation] 小児がんに対する陽子線治療の利点と日本での問題点 (2013)
  • Author(s): 櫻井英幸, 福島敬, 水本斉志, 大城佳子, 沼尻晴子, 大西かよ子, 福光延吉, 石川仁, 奥村敏之, 坪井康次, 榮武二, 須磨﨑亮, 増本幸二 and 金子道夫
  • Organizer: 第55回日本小児血液・がん学会学術集会/第11回日本小児がん看護学会/第18回公益財団法人がんの子どもを守る会公開シンポジウム
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Suprasellar GT and endocrinopathy;duration of symptoms and outcome (2013)
  • Author(s): H. Fukushima, T. Fukushima, S. Hosaka, A. Sakai, R. Suzuki, C. Kobayashi, A. Iwabuchi, T. Kamoda, K. Kato, K. Koike, K. Yamazaki, H. Fujisaki, J. Hara, S. Ihara, T. Yamamoto, S. Takano, T. Masumoto, M. Mizumoto, H. Sakurai and R. Sumazaki
  • Organizer: 第55回日本小児血液・がん学会学術集会/第11回日本小児がん看護学会/第18回公益財団法人がんの子どもを守る会公開シンポジウム
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Multidisciplinary therapy including proton beam therapy for Ewing's sarcoma family of tumors (2013)
  • Author(s): R. Suzuki, T. Fukushima, C. Kobayashi, H. Fukushima, A. Sakai, T. Ishida, T. Ohsumi, H. Ochiai, S. Kishimoto, M. Chin, R. Hosogai, Y. Hosoya, A. Watanabe, C. Goto, K. Masumoto, M. Mizumoto, H. Sakurai and R. Sumazaki
  • Organizer: 第55回日本小児血液・がん学会学術集会/第11回日本小児がん看護学会/第18回公益財団法人がんの子どもを守る会公開シンポジウム
  • Place of Presentation: 福岡
  • Invited
• [Presentation] 筑波大学における頭頸部ホウ素中性子捕捉療法臨床研究計画について (2013)
  • Author(s): 粟飯原輝人, 和田哲郎, 石川仁, 福光延吉, 奥村敏之, 大西かよ子, 水本斉志, 沼尻晴子, 熊田博明, 大野豊然貴, 瀧澤大地, 菅原香織, 斎藤高, 中村智則, 田中圭一, 加沼玲子, 原晃 and 櫻井英幸
  • Organizer: 第35回茨城医学会耳鼻咽喉科分科会 第72回日耳鼻茨城県地方部会学術講演会
  • Place of Presentation: 水戸
  • Invited
• [Presentation] 婦人科領域癌の骨盤内再発腫瘍に対する組織内照射 (2013)
  • Author(s): 沼尻晴子, 大川綾子, 瀧澤大地, 牧島弘和, 大野豊然貴, 水本斉志, 大西かよ子, 石川仁, 奥村敏之 and 櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
  • Invited
• [Presentation] 陽子線治療と中性子捕捉療法の過去、現在、未来 －難治癌克服に向けて- (2013)
  • Author(s): 櫻井英幸, 奥村敏之, 石川仁, 福光延吉, 粟飯原輝人, 大西かよ子, 水本斉志, 大城佳子, 沼尻晴子, 熊田博明 and 坪井康次
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
  • Invited
• [Presentation] 頸部のデスモイド腫瘍に対して陽子線治療を施行した一例 (2013)
  • Author(s): 田中圭一, 奥村敏之, 水本斉志, 大西かよ子, 石川仁, 粟飯原輝人, 沼尻晴子, 福光延吉, 坪井康次 and 櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
  • Invited
• [Presentation] 陽子線治療を施行した前立腺基底細胞癌の１例 (2013)
  • Author(s): 中村智則, 石川仁, 瀧澤大地, 沼尻晴子, 水本斉志, 大西かよ子, 粟飯原輝人, 福光延吉, 坪井康次, 奥村敏之 and 櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
  • Invited
• [Presentation] 胆管ステントがCTV内にある肝胆膵悪性腫瘍に対する陽子線治療の経験 (2013)
  • Author(s): 大野豊然貴, 奥村敏之, 布施拓, 牧島弘和, 瀧澤大地, 菅原香織, 水本斉志, 石川仁, 榮武二 and 櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
  • Invited
• [Presentation] 食道扁平上皮癌に対する同時化学療法併用陽子線治療成績 (2013)
  • Author(s): 石川仁, 大野豊然貴, 橋本孝之, 水本斉志, 大西かよ子, 粟飯原輝人, 沼尻晴子, 福光延吉, 奥村敏之 and 櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
  • Invited
• [Presentation] 小児頭蓋内上衣腫に対する陽子線治療 (2013)
  • Author(s): 水本斉志, 瀧澤大地, 大城佳子, 沼尻晴子, 大西かよ子, 福光延吉, 石川仁, 奥村敏之, 坪井康次 and 櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
  • Invited
• [Presentation] 切除不能篩骨洞扁平上皮癌に対する陽子線治療の初期経験 (2013)
  • Author(s): 斎藤高, 石川仁, 水本斉志, 大西かよ子, 福光延吉, 粟飯原輝人, 奥村敏之 and 櫻井英幸
  • Organizer: 日本放射線腫瘍学会第26回学術大会
  • Place of Presentation: 青森
  • Invited
• [Presentation] Comparison of adverse effects proton and X-ray chemoradiotherapy for oesophageal cancer using an adaptive dose-volume histogram (2013)
  • Author(s): H. Makishima, H. Ishikawa, T. Terunuma, T. Hashimoto, K. Yamanashi, T. Sekiguchi, M. Mizumoto, T. Okumura, K. Tsuboi and H. Sakurai
  • Organizer: The European Cancer Congress 2013
  • Place of Presentation: Amsterdam, Holland
  • Invited
• [Presentation] Proton beam therapy for a patient with large rhabdomyosarcoma of the body trunk (2013)
  • Author(s): D. Takizawa, Y. Oshiro, T. Okumura, M. Mizumoto, N. Fukumitsu, H. Ishikawa, K. Tsuboi, M. Kaneko and H. Sakurai
  • Organizer: 45th Congress of the International Society of Paediatric Oncology
  • Place of Presentation: Hong Kong, China
  • Invited
• [Presentation] Proton beam therapy for pediatric patients with pediatric ependymoma (2013)
  • Author(s): M. Mizumoto
  • Organizer: 45th Congress of the International Society of Paediatric Oncology
  • Place of Presentation: Hong Kong, China
  • Invited
• [Presentation] Long-term survival in patients with hepatocellular carcinoma initially treated with definitive proton beam therapy (2013)
  • Author(s): T. Okumura, K. Fukuda, T. Hashimoto, M. Mizumoto, H. Ishikawa, T. Sakae, M. Abei, K. Tsuboi and H. Sakurai
  • Organizer: 55th Anuual Meeting of the American Society for Radiation Oncology(ASTRO2013)
  • Place of Presentation: Atlanta, USA
  • Invited
• [Presentation] メタストロンの当院での治療経験と導入適応についての検討 (2013)
  • Author(s): 瀧澤大地, 大野豊然貴, 福光延吉, 水本斉志, 大西かよ子, 沼尻晴子, 粟飯原輝人, 石川仁, 奥村敏之, 坪井康次 and 櫻井英幸
  • Organizer: 第6回茨城放射線腫瘍研究会
  • Place of Presentation: つくば
• [Presentation] 切除不能篩骨洞扁平上皮癌に対する陽子線治療の初期経験 (2013)
  • Author(s): 斎藤高, 石川仁, 水本斉志, 福光延吉, 奥村敏之 and 櫻井英幸
  • Organizer: 第37回日本頭頸部癌学会
  • Place of Presentation: 東京
  • Invited