Analysis of the mechanism of the radiation resistance in non-small cell lung cancer

Research Project

Project/Area Number	25861069
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Radiation science
Research Institution	Gunma University
Principal Investigator	Okano Naoko 群馬大学, 医学部附属病院, 助教 (00647349)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	放射線抵抗性 / がん幹細胞 / 放射線抵抗性細胞 / FACS / CD133
Outline of Final Research Achievements	This studies were aimed to clarify if the carbon ion beam was superior to X-ray resistant cells of non-small cell lung cancer and the molecular biological mechanisms of radio resistance. At first, we calculated the Relative Biological Effectiveness (RBE) of carbon ion beam to X-ray and irradiated the cells by the dose computed with RBE. Then we attempted to derive radiation-resistant cells used with flow cytometry system and antibody to cell surface antigens, but we couldn’t identify expressed factors in radio resistant cells and couldn’t derive selectively.

Report

(4 results)