Analysis of the mechanism of the radiation resistance in non-small cell lung cancer
Project/Area Number |
25861069
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Radiation science
|
Research Institution | Gunma University |
Principal Investigator |
Okano Naoko 群馬大学, 医学部附属病院, 助教 (00647349)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 放射線抵抗性 / がん幹細胞 / 放射線抵抗性細胞 / FACS / CD133 |
Outline of Final Research Achievements |
This studies were aimed to clarify if the carbon ion beam was superior to X-ray resistant cells of non-small cell lung cancer and the molecular biological mechanisms of radio resistance. At first, we calculated the Relative Biological Effectiveness (RBE) of carbon ion beam to X-ray and irradiated the cells by the dose computed with RBE. Then we attempted to derive radiation-resistant cells used with flow cytometry system and antibody to cell surface antigens, but we couldn’t identify expressed factors in radio resistant cells and couldn’t derive selectively.
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Report
(4 results)
Research Products
(2 results)